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41.
Longitudinal assessment of hepatic fibrosis in responders to direct‐acting antivirals for recurrent hepatitis C after liver transplantation using noninvasive methods
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Heba Omar Mohamed Said Rasha Eletreby Mai Mehrez Mohamed Bassam Zeinab Abdellatif Adel Hosny Sherif Megawer Mona El Amir Ayman Yosry 《Clinical transplantation》2018,32(8)
Successful eradication of recurrent hepatitis C virus (HCV) infection following liver transplantation (HCV) improves graft survival. This study aimed at evaluation of hepatic fibrosis changes among long‐term responders to DAA therapy for recurrent HCV after liver transplantation using noninvasive methods. Patients with significant hepatic fibrosis (≥F2) who achieved SVR12 after treatment with DAAs for recurrent HCV were included (n = 52). Hepatic fibrosis status was assessed, noninvasively, by calculation of fibrosis‐4 score (FIB‐4) and Aspartate Aminotransferase Platelet Ratio Index (APRI) and by measurement of graft stiffness using FibroScan at baseline and 12 and 18 months post‐treatment. Acoustic radiation force imaging (ARFI) was done for all patients 12 and 18 months post‐treatment. Patients were classified into two groups based on baseline liver stiffness measurement (LSM) by FibroScan; significant fibrosis (F2; n = 28) and advanced fibrosis groups (≥F3). Over 18‐month follow‐up period, there was serial improvement of FIB‐4, APRI, and LSM by FibroScan in both groups. Higher baseline LSM and delayed initiation of antiviral therapy were significant predictors of lack of fibrosis regression (P‐value 0.01 and 0.04, respectively). Fibroindices and LSM improved over time in liver transplant recipients who responded to DAAs. Baseline LSM can predict post‐treatment fibrosis regression. 相似文献
42.
Soodeh Razeghi Jahromi Maryam Abolhasani Zeinab Ghorbani Solmaz Sadre-Jahani Zahra Alizadeh Mohammad Talebpour Alipasha Meysamie Mansoureh Togha 《Obesity surgery》2018,28(1):87-96
Introduction
There is evidence that substantial weight loss through bariatric surgery (BS) may result in short-term improvement of migraine severity. However, it still remains to be seen whether smaller amounts of weight loss have a similar effect on migraine headache. This study has been designed to compare the effects of weight reduction through BS and non-surgical modifications.Materials and Methods
Migraine characteristics were assessed at 1 month before (T0), 1 month (T1), and 6 months (T2) after BS (vertical sleeve gastrectomy (VSG) (n = 25) or behavioral therapy (BT) (n = 26) in obese women (aged 18–60 years) with migraine headache. Migraine was diagnosed using the International Classification of Headache Disorders (ICHDIIβ) criteria.Results
There was significant reduction in the visual analog scale (VAS) from the baseline to T1 and T2 in both groups. The number of migraine-free days showed a significant increase within each group (p < 0.001). The BS group had a significant reduction in attack duration (p < 0.001) while there were no changes observed within the BT group. Following the adjustment of ANCOVA models for baseline values of migraine characteristics, age, changes in weight, BMI, body fat, and fat-free mass from T0 to T2, the BS group showed statistically significant lower VAS and duration of migraine attacks and a significantly higher number of migraine-free days than the BT group at T1 and T2 (p ≤ 0.028).Conclusion
Our results indicated that far before significant weight reduction after BS (VSG), there was marked alleviation in the severity and duration of migraine and a significant increase in the number of migraine-free days in obese female migraineurs. However, the effects in the BT group were not comparable with the effects in the BS group.43.
hOGG1 gene polymorphism and breast cancer risk: A systematic review and meta‐analysis study
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Ali Sanjari Moghaddam MD Milad Nazarzadeh MSc Zeinab Bidel MSc Aliasghar Karamatinia PhD Hossein Darvish PhD Alireza Mosavi Jarrahi PhD 《The breast journal》2018,24(1):70-73
To address the effect of hGGO1 (rs1052133) gene polymorphism on the risk of breast cancer, a meta‐analysis was performed. We pooled adjusted odds ratios (OR) as overall and three subgroups (menopausal status, ethnicity, and study setting). In overall analysis, we found a significant association when the model of inheritance was homozygote (pooled OR 1.14; 95% CI 1.01, 1.29). Subgroup analysis showed significant association for homozygote genetic models among postmenopause women (OR 1.23; 95% CI 1.01, 1.49) and Asian population (OR 1.17; 95% CI 1.01, 1.35). This study suggested that the carrier of Ser326Cys polymorphism of hOGG1, Cys/Cys vs Ser/Ser, are at higher risk for breast cancer, independent of other hormonal and environmental risk factors. 相似文献
44.
Chelsea C. Pinnix MD PhD Bouthaina S. Dabaja MD Sarah A. Milgrom MD Grace L. Smith MD PhD Zeinab Abou MD Loretta Nastoupil MD Jorge Romaguera MD Francesco Turturro MD Nathan Fowler MD Luis Fayad MD Jason Westin MD Sattva Neelapu MD Michelle A. Fanale MD Maria A. Rodriguez MD Frederick Hagemeister MD Hun Ju Lee MD Yasuhiro Oki MD Michael Wang MD Felipe Samaniego MD Linda Chi MD Bita Esmaeli MD 《Head & neck》2018,40(6):1335-1335
45.
ObjectiveThis study aimed to determine the role of early and late glycation products in modulating inflammation in early diabetes.MaterialsSprague–Dawley rats (130–170 g) were injected with streptozotocin (75 mg/kg, ip) and treated with daily aminoguanidine (AG, 25 mg/kg, ip) or vehicle for 2 or 4 weeks.MethodsThe base of a vacuum-induced blister raised on the hind paw was perfused with substance P (SP, 1 μM) and sodium nitroprusside (SNP, 100 μM). Changes in blood flow and plasma extravasation (PE) were measured. Amadori (1 mg/ml), advanced glycation end products (AGEs, 10 mg/ml), and anti-RAGE IgG (antibody against AGE receptors, 100 μg/ml) were individually perfused prior to SP.ResultsIn diabetic rats, responses to SNP and SP were reduced by 60% and 70%, respectively (P<.05). Amadori increased responses to SNP by 50% and 90% and to SP by 70% and 80% in control and diabetic rats, respectively (both P<.05). SP responses were significantly increased after anti-RAGE IgG (70%) or AG treatments (175%) with PE responses normalized.ConclusionAmadori and anti-AGE agents enhance peripheral vascular responses in diabetes and may ameliorate microvascular damage. 相似文献
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49.
Brominated Flame Retardants in Fish of Lake Geneva (Switzerland) 总被引:1,自引:0,他引:1
Zeinab Cheaib Dominique Grandjean Thomas Kupper Luiz F. de Alencastro 《Bulletin of environmental contamination and toxicology》2009,82(4):522-527
Polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD) were determined in fish (Salmo trutta forma lacustris) from Lake Geneva. Brominated flame retardants were detected in all nine samples with an average concentration for the sum
of BDE-28, BDE-47, BDE-49, BDE-66, BDE-99, BDE-100, BDE-119, BDE-153, BDE-154 and BDE-209 of 207 ng per g lipid weight (ng g lw−1). The congener patterns were dominated by BDE-47. The average concentration of HBCD was 168 ng g lw−1. 相似文献
50.
Chloroacetaldehyde (CAA) is the putative metabolite responsible for ifosfamide-induced nephrotoxicity. Whereas evidence suggests
that sodium 2-mercaptoethanesulfonate (mesna) and amifostine protect renal cells against CAA toxicity in vitro, their efficacy
in clinical studies is controversial. To better understand the discrepancy between in vivo and in vitro results, we combined
the in vivo intraperitoneal administration of either saline or mesna (100 mg/kg) or amifostine (200 mg/kg) in rats and the
in vitro study of CAA toxicity to both proximal tubules and precision-cut renal cortical slices. The measured renal cortical
concentrations of mesna and amifostine were 0.6±0.1 μmol/g and 1.2±0.2 μmol/g, respectively; these drugs did not cause renal
toxicity. Despite this, none of the adverse effects of 0.5 mM CAA was prevented by the previous in vivo administration of
mesna or amifostine. Toxicity of 0.5 mM CAA to rat proximal tubules was shown by the fall of cellular adenosine triphosphate
(ATP), total glutathione and coenzyme A + acetyl-coenzyme A levels and by the altered metabolic viability of renal cells.
Long-term exposure of cortical slices to CAA concentrations ≥30 μM caused severe cell toxicity (i.e. decrease in cellular
ATP, total glutathione, and coenzyme A + acetyl-coenzyme A levels), which was not prevented by the in vivo administration
of mesna or amifostine. 相似文献