经行吊阴痛治验2则

笔者用疏肝和温经法治疗经行吊阴痛 2例 ,介绍如下。1　气阴肝脉李某 ,女 ,37岁 ,1999年 10月 13日初诊。 1月前因生气 ,突发乳房憋胀 ,乳头痛不可触 ,适逢月经来潮 ,又见外阴、阴道及小腹抽掣痛 ,牵引至两侧乳头似有绳索上下牵拉痛 ,月经过后 ,诸症消失。前日又见上述症状 ,今     

加强实验技术队伍建设和实验室管理的思考

实验技术队伍建设和实验室管理是当今高校改革的一个重要环节，教辅工作是整个教学、科研活动中不可缺少的重要组成部分，而实验技术人员又是师资队伍里一个不能分割的群体。目前，多数高校存在着实验技术队伍薄弱，缺乏自我提高意识，实验室管理松懈等现象，在此提出了一些建设性的意见和观点，以利于高校实验室教学和科研工作健康、有序地发展。     

Affinity of Macrocyclic Pyridinophanes and Their Acyclic Analogs to Peripheral Benzodiazepine CNS Receptors

Pharmaceutical Chemistry Journal -     

TLC Determination of Cyclophosphamide Degradation Products in Parent Substance and Drug Preparations

Pharmaceutical Chemistry Journal -     

Intramolecular Thermal Condensation of 3-Acetyl-5-Oxopyrazolo[1,5-a]quinoline-4-ethylcarboxylate: a Simple Pathway to the New Tetracyclic System Containing Fluoroquinolone Fragment

Pharmaceutical Chemistry Journal -     

子宫内膜息肉的宫腔镜诊断和治疗价值

目的：阐明官腔镜对子宫内膜息肉的诊断和治疗价值。方法：对行宫腔镜检查的1676例患者中360例子宫内膜息肉进行研究分析，对其中的56例行经宫颈子宫内膜息肉电切术(TCRP)，术后3个月常规复查。结果：子宫内膜息肉的患病率为21．5％(360／1676)，绝经后子宫出血患者阳性病例为186例，其中子宫内膜息肉43例(23．1％)。结论：(1)子宫内膜息肉的临床特征以不规则阴道出血为主，绝经期则以绝经后出血为主；(2)绝经后妇女体内仍有雌激素持续作用；(3)宫腔镜是子宫内膜息肉诊断和治疗的首选方法。     

甘露醇和低温对兔骨骼肌缺血再灌流损伤的保护作用

通过兔后肢缺血模型，观察了甘露醇和低温对骨骼肌缺血再灌流损伤的保护作用。结果：甘露醇和低温可以不同程度地降低再灌流后患肢静脉回流血中细胞内酶（ＣＰＫ、ＬＤＨ、ＡＳＴ）的活性和脂质过氧化反应终末代谢产物丙二醛（ＭＤＡ）的含量，减轻骨骼肌细胞超微结构的破坏。两者单独应用效果不明显（Ｐ＞０．０５），联合应用效果非常明显（Ｐ＜０．０１）。提示自由基介导的脂质过氧化反应参与骨骼肌缺血再灌流损伤，甘露醇和低温对其具有协同保护作用。     

Dynamic observations on NK cell activity and IL-2 and IFNγ productionin vitro in patients on maintenance hemodialysis

Summary In order to study the immune function of patients on maintenance hemodialysis (MHD), we assayed NK cell cytotoxicity against K⁵⁶² targets in 40 patients on MHD, and the production of IL-2 and IFN in peripheral blood mononuclear cells (PBMC) after PHA stimulation, in contrast to those in normal controls. The results showed that NK cell activity and IL-2 and IFN levels were markedly lower in the patients than in the controls. Afeter a single dialysis, NK cell activity as well as IL-2 and IFN levels were elevated to different extent. But there was no significant change in patients after long-term dialysis. There was a positive correlation between the NK cell activity and IL-2 and IFN activity in the controls, but no such correlation was found in the patients on MHD. There was a positive correlation between the NK cell activity and IL-2 activity in patients after dialysis, suggesting that immune function were impaired in the patients on MHD, with a decline in the activity of NK cell and IL-2 and IFN, and a disorder of immune regulation cycle. These abnormal immune impairments in the patients could be partly corrected by hemodialysis. However, long-term hemodialysis is not much helpful in the improvement of patient’s immune function.     

根据桂枝汤的效应消除半衰期和表观消除半衰期制订给药方案的探讨

为探讨药效法估测的效应消除半衰期和效量法估测的表观半衰期对合理制订给药方案的意义和作用,以桂枝汤解热和抗炎的药物动力学实验中所得的相应参数值设计了给药方案,观察了它们在提高药效上的作用。结果表明在给药总剂量相等、首次给药同时开始的情况下,以半衰期设计的给药方案组的药效均明显高于习惯的一次给药组;而以效应消除半衰期设计给药方案组药效增强率又高于以表观半衰期设计的方案组。提示效应消除半衰期比表观半衰期似更有实践意义。