In vitro activity of tigecycline against clinical isolates of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, Serratia marcescens and Enterobacter cloacae

BACKGROUND AND PURPOSE: Strains of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have spread widely in Taiwan hospitals. In this study, we evaluated the in vitro antimicrobial activity of tigecycline against ESBL-producing Enterobacteriaceae, including Klebsiella pneumoniae, Serratia marcescens and Enterobacter cloacae. METHODS: 104 confirmed ESBL-producing bacteria were isolated from 4 hospitals in mid- and southern Taiwan between 2000 and 2006. The in vitro activity of tigecycline against these ESBL producers was tested by use of Etest strips. RESULTS: The minimal tigecycline concentration at which 50% of isolates were inhibited and minimal concentration at which 90% of isolates were inhibited for ESBL-producing isolates ranged from 0.38 to 0.75 mug/mL and 0.5 to 1.5 mug/mL, respectively. CONCLUSIONS: Tigecycline, a new semisynthetic glycylcycline, may be considered an alternative drug of choice for patients infected with ESBL-producing bacteria.     

Use of monoclonal antibodies against myosin light chains 1 to detect the corresponding antigen in blood of patients with myocardial infarction

Research Institute of Human Genetics, All-Union Medical Genetics Research Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 10, pp. 416–417, October, 1991.     

Effect of recent alcohol intake on acceptor properties of high-density lipoproteins and their interaction with liver cells

Institute of Therapy, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. All-Union Preventive Medicine Research Center, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR Yu. P. Nikitin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 110, No. 12, pp. 611–613, December, 1990.     

Biological activity of thymus preparations from sheep of different ages

Research Institute of Epidemiology, Microbiology, and Infectious Diseases, Ministry of Health of the Uzbek SSR. Department of Immunology, Central Research Laboratory, Medical Institute, Tashkent. Research Institute of Physicochemical Medicine, Ministry of Health of the RSFSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR Yu. M. Lopukhin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 105, No. 3, pp. 308–309, March, 1988.     

Experimental analysis of the humoral mechanism of microcirculatory disturbances after thermal and mechanical injury inducing shock in parabiotic rats

Mechanical or thermal injury to one of a pair of parabiotic rats with a crossed circulation but separate innervation was followed by the development of a state resembling shock in the other partner. Microcirculatory changes characteristic of either traumatic or burn shock developed in its mesentery under these circumstances. The results are interpreted as evidence in support of a humoral rather than a nervous mechanism of the microcirculatory disturbances in these types of shock.Laboratory of Pathophysiology of Extremal States, Research Institute of General Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 10, pp. 416–418, October, 1978.     

Possible involvement of nitric oxide in the pathogenesis of experimental convulsions of various genesis

The content of nitric oxide in convulsions of different genesis is assessed by measuring the formation of paramagnetic mononitrosyl iron complexes with diethylthiocarbamate by electron paramagnetic resonance. A 3- to 4-fold increase in the content of these complexes is found in the brain of rats with thiosemicarbazide- or N-methyl-DL-aspartate-induced seizures in comparison with control animals. A similar increase in the brain NO content was observed in maximum electrical stimulation of metrazol-induced convulsions. These changes were accompanied by elevation of secondary lipid peroxidation products. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 26–29, January, 1998