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101.
Penetrating cardiac injuries commonly occur secondary to gunshot or stab wounds. This is a report an unusual case of a patient who sustained a penetrating cardiac injury due to a nail from a terrorism-related, nail-bomb explosion. Associated problems included pericardial tamponade, penetrating cardiac injuries, acute, traumatic, myocardial infarction, and a penetrating lung injury. Prompt diagnosis and aggressive surgical intervention resulted in full recovery of the patient. 相似文献
102.
Gaynes R Richards C Edwards J Emori TG Horan T Alonso-Echanove J Fridkin S Lawton R Peavy G Tolson J 《Emerging infectious diseases》2001,7(2):295-298
We describe the Centers for Disease Control and Prevention's National Nosocomial Infections Surveillance system. Elements of the system critical for successful reduction of nosocomial infection rates include voluntary participation and confidentiality; standard definitions and protocols; identification of populations at high risk; site-specific, risk- adjusted infection rates comparable across institutions; adequate numbers of trained infection control professionals; dissemination of data to health-care providers; and a link between monitored rates and prevention efforts. 相似文献
103.
Noriaki Watanabe M.D. Toshiro Inoue M.D. Izuru Shikata M.D. Joji Kukita M.D. Yasufumi Okabe M.D. Nagahide Goya M.D. 《Pediatrics international》1981,23(1):128-131
A young girl with perinatal history of breech presentation and Caesarian section delivery exhibited symptoms of diabetes insipidus and marked shortness of stature. Possibility of anti-diuretic hormone and growth hormone deficiencies was ruled out completely by extensive endocrinological studies, which instead demonstrated the existence of nephrogenic diabetes insipidus (NDI) in this patient. Turner's syndrome was denied by normal female karyotype. Her dwarfism could not be explained by other causes than NDI. Review of the literature, however, shows that combination of NDI and dwarfism is extremely rare condition in a female case of the disease. 相似文献
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Kiyoe Tetsuka Tomoji Hoshi Eiji Sumiya Hiroshi Kitakoji Yasufumi Yada Fumiya Hongo Hiroki Watanabe Masahito Saitoh 《Journal of Medical Ultrasonics》2003,30(4):247-251
Object: We studied the relationship between age and renal blood flow parameters to determine the clinical significance of using
Doppler color flow imaging (CFI) in their measurement.Subjects and Methods: One hundred forty-four healthy subjects with no renal or circulatory diseases took part in this study. All subjects were
placed in the prone position and examined with CFI. The kidney was visualized in a longitudinal view, and blood flow in the
interlobar arteries was studied. Peak systolic flow velocity (Vmax), end-diastolic flow velocity (Vmin), and resistive index
(RI) were used as blood flow parameters.Results: Age and Vmax were not significantly associated (p=0.03) in the interlobar artery. Vmin decreased significantly (p<0.01)
with age, while RI increased significantly (p<0.01) with age. No statistically significant sex-related renal blood flow parameters
were found.Discussion: Ishimura et al have reported that RI was significantly correlated with age in diabetic patients. Here the same result was
obtained in healthy subjects. The incidence of arteriosclerosis is known to increase with age. In general, RI is influenced
by vascular resistance. Increase in RI with age in this study was explained by the effect of arteriosclerosis on age-related
vascular resistance. These results suggest that age should be considered in the study of blood flow in the kidney. 相似文献
107.
P-Glycoprotein-Mediated Transport of Itraconazole across the Blood-Brain Barrier 总被引:3,自引:0,他引:3
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Tetsuo Miyama Hitomi Takanaga Hirotami Matsuo Katsuhiro Yamano Koujirou Yamamoto Tatsuji Iga Mikihiko Naito Takashi Tsuruo Hitoshi Ishizuka Yukinori Kawahara Yasufumi Sawada 《Antimicrobial agents and chemotherapy》1998,42(7):1738-1744
The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with the plasma ITZ concentration until 24 h after intravenous injection of the drug (half-life, 5 h); however, the ITZ in brain tissue rapidly disappeared (half-life, 0.4 h). The time profiles of the brain/plasma ITZ concentration ratio (Kp value) showed a marked overshooting, and the Kp value increased with increasing dose; these phenomena were not observed in the liver tissue. This finding indicates the occurrence of a nonlinear efflux of ITZ from the brain to the blood. Moreover, based on a pharmacokinetic model which hypothesized processes for both nonlinear and linear effluxes of ITZ from the brain to the blood, we found that the efflux rate constant in the saturable process was approximately sevenfold larger than that in the nonsaturable process. The Kp value for the brain tissue was significantly increased in the presence of ketoconazole or verapamil. The brain Kp value for mdr1a knockout mice was also significantly increased compared with that of control mice. Moreover, the uptake of vincristine or vinblastine, both of which are substrates of the P glycoprotein (P-gp), into mouse brain capillary endothelial cells was also significantly increased by ITZ or verapamil. In conclusion, P-gp in the brain capillary endothelial cells participates in a process of active efflux of ITZ from the brain to the blood at the blood-brain barrier, and ITZ can be an inhibitor of various substrates of P-gp. 相似文献
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109.
Giant cell‐rich osteosarcoma of the vertebra with murine double minute chromosome 2‐ and cyclin‐dependent kinase 4‐positive and histone H3F3A mutant p.Gly34Trp‐negative immunophenotypes
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