全文获取类型
收费全文 | 669696篇 |
免费 | 311454篇 |
国内免费 | 58433篇 |
专业分类
耳鼻咽喉 | 6930篇 |
儿科学 | 9837篇 |
妇产科学 | 8721篇 |
基础医学 | 135763篇 |
口腔科学 | 9835篇 |
临床医学 | 113197篇 |
内科学 | 154746篇 |
皮肤病学 | 10242篇 |
神经病学 | 42600篇 |
特种医学 | 24485篇 |
外国民族医学 | 200篇 |
外科学 | 86809篇 |
综合类 | 122730篇 |
现状与发展 | 98篇 |
一般理论 | 58篇 |
预防医学 | 70162篇 |
眼科学 | 27381篇 |
药学 | 98874篇 |
399篇 | |
中国医学 | 67470篇 |
肿瘤学 | 49046篇 |
出版年
2023年 | 7922篇 |
2022年 | 18227篇 |
2021年 | 23080篇 |
2020年 | 20514篇 |
2019年 | 24870篇 |
2018年 | 26780篇 |
2017年 | 26385篇 |
2016年 | 24195篇 |
2015年 | 30714篇 |
2014年 | 34945篇 |
2013年 | 34516篇 |
2012年 | 45529篇 |
2011年 | 49617篇 |
2010年 | 39745篇 |
2009年 | 43233篇 |
2008年 | 36278篇 |
2007年 | 32943篇 |
2006年 | 31791篇 |
2005年 | 30296篇 |
2004年 | 25123篇 |
2003年 | 23456篇 |
2002年 | 21456篇 |
2001年 | 21398篇 |
2000年 | 16414篇 |
1999年 | 20982篇 |
1998年 | 18602篇 |
1997年 | 18223篇 |
1996年 | 18339篇 |
1995年 | 18309篇 |
1994年 | 17472篇 |
1993年 | 15206篇 |
1992年 | 15633篇 |
1991年 | 14522篇 |
1990年 | 13171篇 |
1989年 | 12712篇 |
1988年 | 12058篇 |
1987年 | 11355篇 |
1986年 | 10629篇 |
1985年 | 9433篇 |
1984年 | 7188篇 |
1983年 | 7045篇 |
1982年 | 7889篇 |
1981年 | 7425篇 |
1980年 | 7015篇 |
1979年 | 7041篇 |
1978年 | 6065篇 |
1977年 | 6312篇 |
1976年 | 5915篇 |
1975年 | 5665篇 |
1974年 | 5257篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
当代社会,老年人口比例呈现不断上升的趋势,老龄化问题日益严峻。因此,如何有效地延缓衰老不仅成为了世界医学研究的热点,也成为了全球亟待解决的问题。中医药在延缓衰老方面经验丰富,而滋阴药在此类研究中效果显著。本文通过整理滋阴药抗衰老作用机制的若干文献,对滋阴复方六味地黄丸、二至丸、左归丸及其他滋阴中药延缓衰老的机制研究进展进行综述。 相似文献
62.
Unconditional Positivity-Preserving and Energy Stable Schemes for a Reduced Poisson-Nernst-Planck System
下载免费PDF全文
![点击此处可从《Communications In Computational Physics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hailiang Liu & Wumaier Maimaitiyiming 《Communications In Computational Physics》2020,27(5):1505-1529
The Poisson-Nernst-Planck (PNP) system is a widely accepted model for
simulation of ionic channels. In this paper, we design, analyze, and numerically validate a second order unconditional positivity-preserving scheme for solving a reduced
PNP system, which can well approximate the three dimensional ion channel problem.
Positivity of numerical solutions is proven to hold true independent of the size of time
steps and the choice of the Poisson solver. The scheme is easy to implement without
resorting to any iteration method. Several numerical examples further confirm the
positivity-preserving property, and demonstrate the accuracy, efficiency, and robustness of the proposed scheme, as well as the fast approach to steady states. 相似文献
63.
Xin Yi Wong Andrew Qi Jun Lim Qianyu Shen John Whay Kuang Chia Min Hoe Chew Wah Siew Tan 《Current medical research and opinion》2020,36(10):1677-1686
Abstract
Objective
Ras wild-type metastatic colorectal cancers (mCRC) may be treated with anti-vascular endothelial growth factor (VEGF) or anti-epidermal growth factor receptor (EGFR) agents. We aim to estimate patients’ preferences for mCRC treatment and relative importance of cost, efficacy improvement, avoidance of side effects and therapy convenience, and relative uptake between profiles that resemble Bevacizumab (anti-VEGF) and Cetuximab (anti-EGFR), two commonly prescribed mCRC targeted therapies. 相似文献64.
Yaqian Li Jingjing Yu Yun Kuang Chengkun Wu Liu Yang Qiulian Fang 《Current medical research and opinion》2020,36(9):1433-1439
Abstract
Objective
The sex, age, medical history, treatment, tobacco use, race risk (SAMe-TT2R2) Score; the sex, age, medical history, treatment, tobacco use, genotype combination (SAMe-TT2G2) Score; and the so-called modified SAMe-TT2R2 scores have been proposed to predict the anticoagulation quality for patients with non-valvular atrial fibrillation (NVAF). The data from a prospective controlled study is used to validate the SAMe-TT2R2 and SAMe-TT2G2 scores in Chinese NVAF patients treated with warfarin and to evaluate the association of factors with time in therapeutic range (TTR) to predict the quality of oral anticoagulation control. 相似文献65.
Jianhui Su Chaoyang Ma Chengxiang Liu Chuanzhong Gao Rongjing Nie 《International journal of food sciences and nutrition》2016,67(1):20-28
This study investigated the hypocholesterolaemic effects of bitter melon aqueous extracts (BMAE) in vitro, the inhibitory effects of BMAE on pancreatic cholesterol esterase (CEase) and incorporation of cholesterol into micelles were investigated. BMAE decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. The conformation of CEase was investigated by means of circular dichroism (CD) and fluorescence. The result revealed the decrease of α-helix contents, increase of β-sheet and exposure of aromatic amino acid residuals. The incorporation of cholesterol into micelles was inhibited by BMAE. A complex was observed by transmission electron microscopy (TEM), which indicated interaction between cholesterol and BMAE. The result revealed that BMAE can play a role in decreased intestinal cholesterol absorption via inhibition of CEase, and of micelle formation. 相似文献
66.
目的 探讨快速康复外科 (FTS)理念在经后颅窝乙状窦后入路三叉神经微血管减压术围术期患者护理中的应用效果。方法 选择2018年1月~2019年1月我院收治并行经后颅窝乙状窦后入路三叉神经微血管减压患者100例,随机分成观察组和对照组,每组50例。对照组应用常规方法进行围术期护理,观察组应用FTS理念进行围术期护理。比较两组焦虑情况、术后并发症发生率、平均住院日及平均住院费用。结果 观察组轻度焦虑多于对照组,中、重度焦虑少于对照组(P<0.05);观察组术后并发症发生率低于对照组[恶心呕吐(4.00% vs 16.00%)、尿路感染(4.00% vs 18.00%)、颅内感染(0 vs 8.00%)、颅内血肿(2.00% vs 14.00%)和术后应激性疼痛(16.00% vs 34.00%)],差异有统计学意义(P<0.05);观察组平均住院日和平均住院费用均低于对照组[(9.13±1.14)d vs(12.44±0.89)d];[(2.15±0.66)万元 vs (3.05±0.61)万元],差异有统计学意义(P<0.05)。结论 应用FTS理念能缓解经后颅窝乙状窦后入路三叉神经微血管减压术患者术前紧张恐惧的心理,减少术后并发症,缩短患者住院日,降低住院费用,护理效果较好。 相似文献
67.
68.
The objective of this study was to investigate short segment decompression of degenerative lumbar scoliosis (DLS) and the efficiency of fusion treatment.After DLS surgery, the patients were retrospectively reviewed using the VAS (visual analog scale) and ODI (Oswestry Disability Index) to assess clinical outcomes. All patients underwent posterior lumbar decompressive laminectomy, pedicle screw internal fixation, and posterolateral bone graft fusion surgery. Radiographic measurements included the scoliotic Cobb angle, the fused Cobb angle, the anterior intervertebral angle (AIA), the sagittal intervertebral angle (SIA), and lumbar lordosis angle. The relationships between these parameters were examined by bivariate Pearson analysis and linear regression analysis.Preoperatively, the Cobb angle at the scoliotic segment was 15.4°, which decreased to 10.2° immediately following surgery (P < 0.05). The AIA significantly increased by the last follow-up (4.4 ± 3.4) compared with pre- and postoperative values (2.5 ± 2.8 and 2.2 ± 2.4, respectively; P < 0.05). However, the scoliotic Cobb angle and the AIA did not correlate with the VAS or ODI scores. At the final follow-up, no patients had pseudoarthrosis or internal instrumentation-related complications.Short fusion surgical treatment results in limited DLS correction, with correction loss over time. The AIA between the upper adjacent segment and proximal fused vertebra continues to increase postoperatively, which does not exacerbate clinical symptoms, as reflected by the low reoperation rates for repairing degeneration at adjacent levels. 相似文献
69.
70.
我国属胃癌高发国家,且以进展期胃癌为主。以手术和化疗为主的多学科治疗无法有效改善晚期胃癌患者的预后。近年来,免疫检查点抑制剂类药物的疗效在诸多癌症中得到了证实,因此,该类药物在胃癌中的治疗效果也受到了广泛的关注。本文对近年来的相关研究成果进行综述,全面介绍了免疫检查点抑制剂类药物在胃癌治疗中的临床应用情况、联合用药情况以及不良反应。对于其他治疗均失败的晚期胃癌患者,PD-1抑制剂是一个可行的治疗选项,其代表药物派姆单抗是目前唯一被美国食品药品监督管理局批准应用于胃癌治疗的免疫抑制剂类药物,而我国国家食品药品监督管理总局尚未批准任何此类药物应用于胃癌的临床治疗。如何进一步提高治疗的客观缓解率,将会是后续临床和基础研究的一大焦点。 相似文献