全文获取类型
收费全文 | 2035篇 |
免费 | 88篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 161篇 |
妇产科学 | 83篇 |
基础医学 | 149篇 |
口腔科学 | 68篇 |
临床医学 | 178篇 |
内科学 | 405篇 |
皮肤病学 | 34篇 |
神经病学 | 113篇 |
特种医学 | 100篇 |
外科学 | 419篇 |
综合类 | 28篇 |
预防医学 | 35篇 |
眼科学 | 78篇 |
药学 | 50篇 |
中国医学 | 5篇 |
肿瘤学 | 167篇 |
出版年
2023年 | 13篇 |
2022年 | 16篇 |
2021年 | 32篇 |
2020年 | 23篇 |
2019年 | 30篇 |
2018年 | 43篇 |
2017年 | 34篇 |
2016年 | 60篇 |
2015年 | 69篇 |
2014年 | 92篇 |
2013年 | 149篇 |
2012年 | 160篇 |
2011年 | 162篇 |
2010年 | 96篇 |
2009年 | 100篇 |
2008年 | 184篇 |
2007年 | 170篇 |
2006年 | 160篇 |
2005年 | 157篇 |
2004年 | 143篇 |
2003年 | 79篇 |
2002年 | 79篇 |
2001年 | 30篇 |
2000年 | 9篇 |
1999年 | 10篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 2篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1981年 | 1篇 |
1975年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有2143条查询结果,搜索用时 15 毫秒
11.
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D
下载免费PDF全文
![点击此处可从《Genes & development》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ugur Yavuzer Graeme C.M. Smith Tonya Bliss Dieter Werner Stephen P. Jackson 《Genes & development》1998,12(14):2188-2199
DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-strand break repair and V(D)J recombination, is comprised of a DNA-targeting component termed Ku and an ~465-kD catalytic subunit, DNA-PKcs. Although DNA-PK phosphorylates proteins in the presence of DSBs or other discontinuities in the DNA double helix in vitro, the possibility exists that it is also activated in other circumstances via its association with additional proteins. Here, through use of the yeast two-hybrid screen, we discover that the recently identified high affinity DNA binding protein C1D interacts with the putative leucine zipper region of DNA-PKcs. Furthermore, we show that C1D can interact with DNA-PK in mammalian cells and that C1D is a very effective DNA-PK substrate in vitro. Finally, we establish that C1D directs the activation of DNA-PK in a manner that does not require DNA termini. Therefore, these studies provide a function for C1D and suggest novel mechanisms for DNA-PK activation in vivo. 相似文献
12.
Yamac D Celenkoglu G Coskun U Akyurek N Akcali Z Dursun A Koybasioglu F 《Pathology, research and practice》2005,201(7):497-502
A relationship between cyclooxygenase-2 (COX-2) expression and the pathogenesis of colorectal cancer has been reported in recent studies. Moreover, it has been indicated that COX-2 expression may have a prognostic role in colorectal cancer patients. In this study, we investigated the prognostic significance of COX-2 expression in 83 patients with colorectal cancer. COX-2 expression was assessed using immunohistochemical methods and was evaluated by grading both staining intensity and staining extension. The relationships between COX-2 expression and clinicopathological features of the patients and patient survival were evaluated. There was no relationships between COX-2 expression and tumor size (tm < 3 cm or tm > or = 3 cm), tumor histopathological differentiation (poorly differentiated or moderately + well differentiated), number of metastatic lymph nodes (< 4 or 3 > or = 4), histopathology of the tumor, localization of the tumor (colon or rectum), distant metastasis, and vascular invasion of the tumor. In the multivariate analysis, COX-2 expression was not found as an independent prognostic factor. We demonstrated that COX-2 expression was not correlated with clinicopathological characteristics of colon carcinoma and disease outcome. 相似文献
13.
Cankal F Ugur HC Tekdemir I Elhan A Karahan T Sevim A 《Clinical anatomy (New York, N.Y.)》2004,17(2):118-122
The fossa navicularis is a relatively rare anatomic variation of the skull base. Awareness of its existence will avoid misinterpretations of radiological images and unnecessary investigations. This study describes the appearance of the fossa navicularis, and investigates its incidence and whether it is related to pathology at the basiocciput. We studied 492 dry human skulls and 525 computer tomography (CT) images of patients. Dry skulls showing a fossa navicularis were investigated by CT scan, whereas patients identified as having a fossa navicularis were further examined with magnetic resonance imaging (MRI). To document the position of the fossa more precisely, measurements were made between the fossa navicularis and certain anatomic landmarks such as the foramen ovale, the pharyngeal tubercle, the posterior border of the vomer, the foramen lacerum, the carotid canal, and the occipital condyle. Upon examination, 26 of 492 skulls (5.3%) were found to have a fossa navicularis. Twelve were <2 mm in depth and the other 14 had a depth of >/=2 mm. Of the 525 patients, 16 (3.0%) were identified as having a fossa navicularis in CT images. Evaluation of MRIs showed no soft tissue lesions in any of these patients. Comprehensive anatomic details of the fossa navicularis have not been reported in the literature. The results of this study may be useful to radiologists, anatomists, and surgeons interested in the skull base. 相似文献
14.
Casonis skin test and indirect haemagglutination test (IHA) are still used in Turkey. The preoperative IHA test or Casonis skin test results of 120 patients with surgically confirmed hydatidosis were retrospectively studied during 1997–2004. At the same period, 306 patients with non-hydatid disease had serologic results for echinococcosis. The sensitivity of immediate intradermal reaction, delayed intradermal reaction, and IHA were 70, 62, and 56%, respectively. Casonis skin test components had higher sensitivity than IHA (P<0.01). The specificity of immediate intradermal reaction, delayed intradermal reaction, and IHA were 87, 85, and 84%, respectively. Cystic lesions in non-hydatid patients were localised commonly in the lungs. The occurrence of hydatid disease for pulmonary, hepatic, and renal cysts was 19, 54, and 5%, respectively. An immediate skin reaction to crude hydatid antigens is more useful than IHA. 相似文献
15.
Immune and repair responses in joint tissues and lymph nodes after knee arthroplasty surgery in mice
16.
Ozcan C Ergün O Güçlü C Tümüklü M Alper H Erdener A 《Journal of pediatric surgery》2000,35(10):1523-1525
Parasitic or heterotopic conjoined twins are exceedingly rare, and these cases are referred to as "heteropagus" when there is a parasitic attachment in a nonduplicated fashion to any portion of the body. Epigastric heteropagus twinning refers to the attachment of the parasite to the epigastric region of the autosite. An unusual epigastric heteropagus case is presented with a rudimentary cardiopulmonary and also nearly complete gastrointestinal and genitourinary system of the parasite, and an organogenetic and vascular status of the previously reported cases are reviewed. The current case might be unique for the parasite having a cardiopulmonary development--although rudimentary--and this might be the reason that it has more complete organogenesis than the cases that have been presented previously in the literature. 相似文献
17.
Ugur Selek Mustafa Cengiz Gokhan Ozyigit Ferah Yildiz Ibtisam Lale Atahan 《Radiotherapy and oncology》2005,76(1):107-8; author reply 108
18.
Renal complications of lipodystrophy: A closer look at the natural history of kidney disease
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Baris Akinci Sadiye Mehtat Unlu Ali Celik Ilgin Yildirim Simsir Sait Sen Banu Nur Fatma Ela Keskin Basak Ozgen Saydam Nilufer Kutbay Ozdemir Banu Sarer Yurekli Bekir Ugur Ergur Melda Sonmez Tahir Atik Atakan Arslan Tevfik Demir Canan Altay Ulku Aybuke Tunc Tugba Arkan Ramazan Gen Erdal Eren Gulcin Akinci Aslihan Arasli Yilmaz Habib Bilen Samim Ozen Aygul Celtik Senay Savas Erdeve Semra Cetinkaya Huseyin Onay Sulen Sarioglu Elif Arioglu Oral 《Clinical endocrinology》2018,89(1):65-75
19.
Ayse Rodopman Arman Pinar Ay Nese Perdahli Fis Refika Ersu Ahmet Topuzoglu Ugur Isik Meral Berkem 《Acta paediatrica (Oslo, Norway : 1992)》2011,100(3):420-424
Aim: In this population‐based study, we aimed to determine the total sleep duration (TSD), its association with socio‐economic status (SES) and behavioural symptoms among schoolchildren. Methods: A cross‐sectional study was performed among schoolchildren in Istanbul. A structured questionnaire evaluating the sleep schedule variables was filled out by their parents. SES was determined according to the Turkish SES scale. Results: The mean age of 2669 children was 8.2 ± 2.4 years, and 51% of the students were girls. The mean TSD was 10.20 ± 1.04, and the mean bedtime was 21.57 ± 0.56 (both in hours, minutes ± SD). Boys tended to go bed later (p = 0.004) and slept less than girls (p = 0.02). The duration of sleep disruptions increased (p < 0.001), whereas TSD decreased with age (p < 0.001). Multiple linear regression revealed that waking time and TSD decreased significantly (p < 0.05) with higher SES among both girls and boys. Sleep fragmentation was associated with habitual snoring, parasomnias, daytime sleepiness and conduct symptoms. Conclusion: Decreased total sleep duration is more prominent in boys, older children and children among higher socio‐economic status. Insufficient sleep attributed to shortened total sleep duration by age and higher socio‐economic status might have a negative effect on both sleep hygiene and psychological well‐being in schoolchildren. 相似文献
20.