全文获取类型
收费全文 | 9166篇 |
免费 | 763篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 112篇 |
儿科学 | 339篇 |
妇产科学 | 240篇 |
基础医学 | 1022篇 |
口腔科学 | 379篇 |
临床医学 | 995篇 |
内科学 | 1651篇 |
皮肤病学 | 103篇 |
神经病学 | 859篇 |
特种医学 | 325篇 |
外国民族医学 | 1篇 |
外科学 | 1227篇 |
综合类 | 185篇 |
一般理论 | 9篇 |
预防医学 | 1007篇 |
眼科学 | 271篇 |
药学 | 623篇 |
中国医学 | 21篇 |
肿瘤学 | 583篇 |
出版年
2022年 | 61篇 |
2021年 | 109篇 |
2020年 | 93篇 |
2019年 | 131篇 |
2018年 | 127篇 |
2017年 | 120篇 |
2016年 | 123篇 |
2015年 | 134篇 |
2014年 | 159篇 |
2013年 | 273篇 |
2012年 | 362篇 |
2011年 | 430篇 |
2010年 | 257篇 |
2009年 | 238篇 |
2008年 | 428篇 |
2007年 | 509篇 |
2006年 | 466篇 |
2005年 | 452篇 |
2004年 | 444篇 |
2003年 | 372篇 |
2002年 | 386篇 |
2001年 | 312篇 |
2000年 | 312篇 |
1999年 | 261篇 |
1998年 | 98篇 |
1997年 | 91篇 |
1996年 | 79篇 |
1995年 | 75篇 |
1994年 | 85篇 |
1993年 | 84篇 |
1992年 | 257篇 |
1991年 | 240篇 |
1990年 | 212篇 |
1989年 | 183篇 |
1988年 | 187篇 |
1987年 | 169篇 |
1986年 | 165篇 |
1985年 | 151篇 |
1984年 | 115篇 |
1983年 | 120篇 |
1982年 | 77篇 |
1981年 | 56篇 |
1979年 | 84篇 |
1978年 | 73篇 |
1976年 | 55篇 |
1974年 | 59篇 |
1973年 | 79篇 |
1972年 | 51篇 |
1971年 | 59篇 |
1969年 | 53篇 |
排序方式: 共有9952条查询结果,搜索用时 15 毫秒
51.
Dr. Steven A. Curley MD Robert A. Newman PhD Thomas B. Dougherty MD PhD George M. Fuhrman MD Diana L. Stone BS Jeffrey A. Mikolajek CRNA Sal Guercio CCP Ann Guercio CCP C. Humberto Carrasco MD M. Tien Kuo PhD David C. Hohn MD 《Annals of surgical oncology》1994,1(5):389-399
Background: We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in
patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could
be limited after high-dose hepatic arterial infusion (HAI), and (b) the hepatic maximum tolerated dose (MTD) of doxorubicin.
Methods: Ten patients with biopsy-proven HCC were treated with 20-min HAI of doxorubicin (17 total treatments). Two patients were
treated with doxorubicin 60 mg/m2, three patients were treated at 90 mg/m2, and five patients received 120 mg/m2. A newly developed dual-balloon vena cava catheter was advanced from the femoral vein, and the balloons were inflated to
isolate and capture total hepatic venous outflow. The hepatic venous blood was pumped through extracorporeal carbon chemofilters
before return of the blood to the systemic circulation.
Results: Peak systemic doxorubicin levels were an average 85.6% lower than were peak prefilter levels (p<0.01). Because all catheters
were placed percutaneously and because the chemofiltration markedly limited systemic chemotherapy exposure, patients were
discharged 1 day after 16 of the 17 treatments. The hepatic and systemic MTD of doxorubicin in this treatment protocol was
120 mg/m2.
Conclusions: This novel system of complete hepatic venous isolation and chemofiltration limits systemic chemotherapy toxicity and will
allow use of higher doses of chemotherapeutic agents to treat HCC.
The results of this study were presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles,
California, March 18–21, 1993. 相似文献
52.
53.
Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. 总被引:8,自引:0,他引:8
Dora Il'yasova Lisa H Colbert Tamara B Harris Anne B Newman Douglas C Bauer Suzanne Satterfield Stephen B Kritchevsky 《Cancer epidemiology, biomarkers & prevention》2005,14(10):2413-2418
BACKGROUND: Chronic inflammation is associated with processes that contribute to the onset or progression of cancer. This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence. METHODS: Study subjects (n = 2,438) were older adults (ages 70-79 years) participating in the Health Aging and Body Composition study, who did not report a previous cancer diagnosis (except for nonmelanoma skin cancer) at baseline. Incident cancer events (n = 296) were ascertained during an average follow-up of 5.5 years. Inflammatory markers were measured in stored baseline fasting blood samples. RESULTS: The adjusted hazard ratios (95% confidence intervals) for incident cancer associated with a 1-unit increase on the natural log-scale were 1.13 (0.94-1.37), 1.25 (1.09-1.43), and 1.28 (0.96-1.70) for IL-6, CRP, and TNF-alpha, respectively. Markers were more strongly associated with cancer death: hazard ratios were 1.63 (1.19-2.23) for IL-6, 1.64 (1.20-2.24) for CRP, and 1.82 (1.14-2.92) for TNF-alpha. Although precision was low for site-specific analyses, our results suggest that all three markers were associated with lung cancer, that IL-6 and CRP were associated with colorectal cancer, and that CRP was associated with breast cancer. Prostate cancer was not associated with any of these markers. CONCLUSIONS: These findings suggest that (a) the associations between IL-6, CRP, and TNF-alpha and the risk of cancer may be site specific and (b) increased levels of inflammatory markers are more strongly associated with the risk of cancer death than cancer incidence. 相似文献
54.
Paul S Ramphal Daniel N Coore Michael P Craven Neil F Forbes Somara M Newman Adrian A Coye Sherard G Little Brian C Silvera 《European journal of cardio-thoracic surgery》2005,27(5):910-916
OBJECTIVE: Issues concerning the training and certification of surgical specialists have taken on great significance in the last decade. A realistic computer-assisted, tissue-based simulator developed for use in the training of cardiac surgical residents in the conduct of a variety of cardiac surgical procedures in a low-volume cardiothoracic surgery unit of a typical developing country is described. The simulator can also be used to demonstrate the function of technology specific to cardiac surgical procedures in a way that previously has only been possible via the conduct of a procedure on a live animal or human being. METHODS: A porcine heart in a novel simulated operating theatre environment with real-time simulated haemodynamic monitoring and coronary blood flow, in arrested and beating-heart modes, is used as a training tool for surgical residents. RESULTS: Standard and beating-heart coronary arterial bypass, aortic valve replacement, aortic homograft replacement and pulmonary autograft procedures can be simulated with high degrees of realism and with the superimposition of adverse clinical scenarios requiring valid decision making and clinical judgments to be made by the trainees. CONCLUSIONS: The cardiac surgical simulation preparation described here would appear to be able to contribute positively to the training of residents in low-volume centres, as well as having the potential for application in other settings as a training tool or clinical skills assessment or accreditation device. Collaboration with larger centres is recommended in order to accurately assess the utility of this preparation as an adjunctive cardiothoracic surgical training aid. 相似文献
55.
56.
The ureteral access set was used 43 times during an 18-month period between 1984 and 1985. Stones lodged throughout the ureter and in the renal pelvis were extracted with a success rate of 51 per cent. Of the upper tract strictures 92 per cent were dilated successfully. Filling defects were diagnosed in 88 per cent of the cases. Foreign bodies were retrieved, Double-J stents were placed and biopsies were successful in each case. Ureteral perforation in 28 per cent of the cases was caused by the dilator in 8 of 12 (19 per cent over-all). The technique and short-term results are discussed. Long-term followup data are not yet available. 相似文献
57.
W R Thompson K Newman N Seibel D Bulas S Kapur K D Anderson J Randolph 《Journal of pediatric surgery》1992,27(7):912-915
Resection of a Wilms' tumor that extends into the vena cava or right atrium results in excellent survival when combined with adjuvant therapy. Preoperative identification of the presence of intravascular tumor thrombus and the level of vascular involvement is essential. It facilitates safe surgical resection, with cardiopulmonary bypass immediately available for retrohepatic and atrial tumors. Six patients with intracaval or intracardiac tumor thrombus were treated over a 5-year period with no perioperative deaths. Preoperative chemotherapy was useful in two patients with extensive tumors and pulmonary metastases. Our results using an integrated management plan suggest that an aggressive surgical approach is justified for this extensive variant of Wilms' tumor. 相似文献
58.
59.
M Tyshkov S Berezin S Jayabose H Bostwick M Glassman L Newman 《Journal of pediatric gastroenterology and nutrition》1991,13(2):197-200
A 12-year-old girl is described who developed rectal bleeding 5 months after being diagnosed as having a Coombs-positive hemolytic anemia. Colonoscopy showed that the rectal bleeding was due to ulcerative proctitis. This is the first case report of Coombs-positive hemolytic anemia preceding the onset of ulcerative proctitis in a child. 相似文献
60.