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41.
Yoshimatsu M Kitaura H Fujimura Y Kohara H Morita Y Eguchi T Yoshida N 《Archives of oral biology》2012,57(1):36-43
ObjectiveInterleukin (IL)-12 is an important cytokine for innate and adaptive immunity. We previously reported that IL-12 inhibits tumour necrosis factor (TNF)-α-mediated osteoclast formation by inducing apoptosis. We also reported that TNF-α plays an important role in mechanical loading-induced osteoclast formation and bone resorption during orthodontic tooth movement. In this study, we investigated the effects of IL-12 on mechanical tooth movement in mice.DesignA Ni–Ti closed coil spring was inserted between the upper incisors and the upper left first molar in mice. IL-12 was injected locally adjacent to the first molar every other day during the experimental period, at doses varying from 0 to 1.5 μg/day. After 12 days, the animals were killed and their jaws were processed for histological evaluation using tartrate-resistant acid phosphatase (TRAP) and TdT-mediated dUTP-biotin nick end-labelling (TUNEL) staining, and measurements of the root resorption area.ResultsIn the IL-12-treated mice, tooth movement and root resorption appeared to be reduced. In TUNEL-stained sections, many apoptotic cells were recognized on the pressure side in the IL-12-treated mice.ConclusionsOur findings suggest that IL-12 inhibits not only mechanical tooth movement, but also root resorption during orthodontic tooth movement. These findings may arise through apoptosis induced by IL-12. 相似文献
42.
Hoshino Kento Anan Go Hirose Takuo Yamakoshi Seiko Tajima Ryo Sato Toshihiro Miyake Yuka Fukunaga Tsugumi Kato Toshiko Endo Akari Seki Takayuki Nakayama Shingo Oba-Yabana Ikuko Nakamura Hannah Tani Junichi Mori Takefumi 《Clinical and experimental nephrology》2022,26(8):835-841
Clinical and Experimental Nephrology - Peritoneal dialysis (PD) catheter malposition is one of the complications of renal replacement therapy. This study aimed to determine the preoperative factors... 相似文献
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Hitoshi Shiozaki Yoshiyuki Fujiwara Toshihiro Hirai Hisahiro Matsubara Masaki Mori Tsutomu Nakamura Yukihiro Nakanishi Shoji Natsugoe Tsuyoshi Noguchi Soji Ozawa Yutaka Shimada Seiji Udagawa Hideaki Yamana Masahiko Yano Takushi Yasuda Akio Yanagisawa 《Esophagus》2007,4(1):35-39
Background In esophageal carcinoma, the clinical significance of immunohistochemically (IHC)-detected lymph node (LN) micrometastasis
is still controversial. We designed this multicenter study to determine the clinical significance of IHC-detected LN micrometastasis
in esophageal carcinoma.
Methods The subjects were 164 patients with histopathologically confirmed LN-negative esophageal carcinoma from eight hospitals. A
similar IHC technique was used in all institutions, and micrometastasis was diagnosed by a researcher at each hospital as
well as independently by pathologists with special interest in esophageal carcinoma.
Results IHC-related micrometastasis in LN was considered positive in 51 (31%) patients by the researchers and in 25 (15%) by the pathologists.
The latter micrometastases were further classified into a single (n = 13) and clusters (n = 12) of immunopositive-LN. Kaplan–Meier analysis showed that researcher-based diagnosis of micrometastasis had no significant
impact on prognosis whereas the cluster-type micrometastasis diagnosed by pathologists had a significant impact on prognosis.
Conclusions We speculate that the inconsistent results of IHC analyses reported in the literature are caused by the use of different definitions
of micrometastasis and the subjective nature of diagnosis of micrometastasis, i.e., dependence on the examiner. Our multiinstitutional
study also indicates that the morphological aspects of immunostained cells should be considered when assessing micrometastasis
in LN by IHC and that only LN with clusters of IHC-positive cells are prognostically significant in esophageal carcinoma. 相似文献
45.
Kenjiro Mitsuhashi Akihiro Masuda Yan-Hua Wang Masayuki Shiseki Toshiko Motoji 《International journal of hematology》2014,100(1):88-95
The preferentially expressed antigen of melanoma (PRAME), a tumor-associated antigen, is considered a prognostic marker for various human malignancies. The prognostic significance of PRAME expression for diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab-containing chemotherapy has not been evaluated to date, and the ability of immunohistochemistry (IHC) to detect PRAME expression in these patients has not yet been studied, although IHC is simple to perform in clinical practice. We evaluated the prognostic significance of PRAME expression based on IHC analysis in 160 DLBCL patients treated with R-CHOP therapy. There was a significant association between higher PRAME expression and shorter progression-free survival (PFS), and a trend toward shorter overall survival (OS) in patients with higher PRAME expression than that in patients with lower PRAME expression (5-year PFS, 48.1 vs. 61.1 %; 5-year OS, 65.6 vs. 79.1 %). Patients with high PRAME expression tended to have lower chemotherapeutic responses. Thus, IHC is useful for detecting and assessing PRAME expression in DLBCL. Further, we found a positive correlation between IHC and quantitative real-time RT-PCR measurements of PRAME expression. Our findings indicate that IHC results of PRAME expression can be a novel prognostic maker in DLBCL patients treated with R-CHOP therapy. 相似文献
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48.
Shinkai Inoue Atsushi Ishii Goro Shirotani Makoto Tsutsumi Eiji Ohta Masatoshi Nakamura Toshiko Mori Takahito Inoue Gen Nishimura Atsushi Ogawa Shinichi Hirose 《Pediatrics international》2014,56(4):e26-e29
We report a boy with Desbuquois dysplasia type 1. He had the typical skeletal changes: a “Swedish key” appearance of the proximal femora; advanced carpal ossification and other distinctive features of the hand, including an extra‐ossification center at the base of the proximal phalanx of the index and middle fingers; dislocation of the metacarpophalangeal joint of the index finger; and bifid distal phalanx of the thumb. In addition, he presented with very severe prenatal growth failure, respiratory distress as a neonate, subsequent failure to thrive and susceptibility to airway infection, and sudden death in early childhood. Molecular analysis identified homozygous 1 bp deletion in the Calcium‐Activated Nucleotidase 1 gene (CANT1). To our knowledge, this is the first report of Desbuquois dysplasia type 1 in Japan. Our experience suggests potential lethality in the disorder. 相似文献
49.
Akihiro Nakayama Jun Arai Yumi Otoyama Ikuya Sugiura Yoko Nakajima Atsushi Kajiwara Yuki Ichikawa Shojiro Uozumi Yuu Shimozuma Manabu Uchikoshi Masashi Sakaki Sakiko Tazawa Eisuke Shiozawa Toshiko Yamochi Masafumi Takimoto Hitoshi Yoshida 《Internal medicine (Tokyo, Japan)》2022,61(2):189
There are few case reports of hepatocellular carcinoma (HCC) metastasis to the skeletal muscle. A 78-year-old man developed a mass in the right shoulder. Washout of contrast medium during contrast-enhanced ultrasonography (CEUS) in both the primary HCC and the metastatic site was detected. Several nodules were scattered throughout the liver on an autopsy. In addition, the moderately differentiated HCC had metastasized to the right teres major muscle. Rare muscular metastasis should be considered if a hepatic tumor is moderately or poorly differentiated HCC. Early washout during CEUS is consistent with a pathological diagnosis of moderately or poorly differentiated HCC. 相似文献