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101.
102.
Taneja PR Pandya A Foley DL Nicely LV Arnos KS 《American journal of medical genetics. Part A》2004,(1):17-21
Recent advances have made molecular genetic testing for several forms of deafness more widely available. Previous studies have examined the attitudes of the deaf towards genetic testing, including prenatal diagnosis. This study examines the attitudes of deaf college students towards universal newborn hearing screening, including molecular testing for specific forms of deafness, as well as the utilization of genetic test results for mate selection. We found that there may be differences in the attitudes of deaf individuals who associate closely with the deaf community (DC), and those who have equal involvement with both the deaf and hearing communities (EIC). The majority perceived newborn hearing screening for deafness to be helpful. However, more members of the EIC than the DC groups support newborn testing for genes for deafness. While there was reported interest in using genetic testing for partner selection, most participants reported they would not be interested in selecting a partner to have children with a specific hearing status. The results of this study point out important differences that genetic professionals should be aware of when counseling deaf individuals. 相似文献
103.
Renal cell carcinoma (RCC) is unusual among cancers in that it often grows as a spherical, well‐circumscribed mass. Increasing tumour size influences the pathological pT stage category within pT1 and pT2, with cutoffs of 40, 70 and 100 mm; however, with increasing size also comes a sharp increase in the likelihood of renal sinus or renal vein tributary invasion, such that clear cell RCC rarely reaches 70 mm without invading one of these. To clarify some previous challenges in assigning tumour stage, the American Joint Committee on Cancer 2016 tumor–node–metastasis classification has removed the requirements than vein invasion be recognised grossly and that vein walls contain muscle for the diagnosis of vein invasion. Renal pelvis invasion has also been added as an additional route to pT3a. Multinodularity or finger‐like extensions from a renal mass should be viewed with great suspicion for the possibility of vein or renal sinus invasion, and, as tumour size increases to over 40–50 mm, thorough sampling of the renal sinus interface should always be undertaken. With increasing interest in adjuvant therapy in renal cancer, the pathologist's role in RCC staging will continue to be an important prognostic parameter and a tool for selection of patients for enrolment in clinical trials. 相似文献
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Summary: Predisposition to develop rheumatoid arthritis (RA) has been associated with certain human leukocyte antigen (HLA) class II molecules, although the mechanism is still unknown. Various experimental animal models of inflammatory arthritis have been studied to address the role of major histocompatibility complex (MHC) genes in pathogenesis. We have generated transgenic mice expressing HLA class II molecules (DR and DQ) lacking complete endogenous class II molecules to study the interactions involved between class II molecules (DQ and DR) and to define the immunologic mechanisms in inflammatory arthritis. The HLA transgene can positively select CD4+ T cells expressing various Vβ T-cell receptors, and a peripheral tolerance is maintained to transgenic HLA molecules. The expression of HLA molecules on various cells in these mice is similar to that known in humans. In this review, we describe collagen-induced arthritis as a model for human inflammatory arthritis using these transgenic mice. The transgenic mice carrying RA-susceptible haplotype develop gender-biased inflammatory arthritis with clinical and histopathological similarities to RA. Our studies show that polymorphism of HLA class II genes determine the predisposition to rheumatoid/inflammatory arthritis and the epistatic interactions between HLA-DQ and HLA-DR molecules dictate the severity, progression, and modulation of the disease. 相似文献
107.
Occurrence of lymphocytotoxins in multi-case rheumatoid arthritis families: relation to HLA. 下载免费PDF全文
V Taneja N K Mehra R R Singh C Anand A N Malaviya 《Clinical and experimental immunology》1991,86(1):87-91
The presence of lymphocytotoxic antibodies (LCA) and their association with HLA haplotypes has been studied in 27 multi-case rheumatoid arthritis (RA) families (13 multiplex and 14 simplex) in Northern India. Of the total 59 RA patients, 69.4% had cytotoxins in their sera as compared with 2.5% of healthy controls. No differences were observed in the frequency of LCA in relation to sex and rheumatoid factor. LCA against B cells were significantly more predominant than those against T cells. Twenty families studied for correlation of HLA with LCA showed greater intensity of reaction with DR4+ haplotypes, particularly in simplex families. Similarly, the frequency of LCA among patients and unaffected parents was greater in simplex compared with multiplex families. Haplotype sharing with the patient was increased in the relatives positive for cytotoxins in these families. An immunogenetic contribution made by the affected parent and a common environmental stimulus may be responsible for the increased production of LCA in multi-case families with RA. 相似文献
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109.
Lotte K Vogel Mona S?b? Camilla F Skjelbred Kathrine Abell Esben DK Pedersen Ulla Vogel Elin H Kure 《BMC cancer》2006,6(1):176
Background
It has recently been shown that overexpression of the serine protease, matriptase, in transgenic mice causes a dramatically increased frequency of carcinoma formation. Overexpression of HAI-1 and matriptase together changed the frequency of carcinoma formation to normal. This suggests that the ratio of matriptase to HAI-1 influences the malignant progression. The aim of this study has been to determine the ratio of matriptase to HAI-1 mRNA expression in affected and normal tissue from individuals with colorectal cancer adenomas and carcinomas as well as in healthy individuals, in order to determine at which stages a dysregulated ratio of matriptase/HAI-1 mRNA is present during carcinogenesis. 相似文献110.
Kondraske GV Hamilton EC Scott DJ Fischer CA Tesfay ST Taneja R Brown RJ Jones DB 《Surgical endoscopy》2002,16(11):1523-1527
Background: Surgeons are now being assisted by robotic systems in a wide range of laparoscopic procedures. Some reports have
suggested that robot-assisted camera control (RACC) may be superior to a human driver in terms of quality of view and directional
precision, as well as long-term cost savings. Therefore, we setout to investigate the impact of RACC of surgeon motion efficiency.
Methods: Twenty pigs were randomized to undergo a standardized laparoscopic Nissen fundoplication with either a human or RACC
system, the AESOP 2000. All procedures were performed by the same surgical fellow. Time was recorded for dissection and suture
phases. Inertial motion sensors were used to monitor both the surgeon's hands and the camera. Digitized data were analyzed
to produce summary measures related to overall motion. Results: The operative times were slightly longer with RACC (mean 80.2
± 20.6 vs 73.1 ± 15.4 min, not significant). With regard to operative times and surgeon motion measures, the only statistically
significant differences were for setup and breakdown times, which contributed <15% to the total time for the procedure. Conclusion:
In terms of impact on surgeon motion efficiency and operative time under normal surgical conditions, RACC is essentially the
same as an expert human driver. However, careful planning and structuring of the surgical suite may yield some small gains
in operative time. 相似文献