全文获取类型
收费全文 | 1828篇 |
免费 | 111篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 64篇 |
妇产科学 | 40篇 |
基础医学 | 215篇 |
口腔科学 | 88篇 |
临床医学 | 147篇 |
内科学 | 383篇 |
皮肤病学 | 23篇 |
神经病学 | 91篇 |
特种医学 | 40篇 |
外科学 | 336篇 |
综合类 | 65篇 |
预防医学 | 129篇 |
眼科学 | 28篇 |
药学 | 165篇 |
中国医学 | 23篇 |
肿瘤学 | 69篇 |
出版年
2023年 | 15篇 |
2022年 | 62篇 |
2021年 | 96篇 |
2020年 | 47篇 |
2019年 | 67篇 |
2018年 | 91篇 |
2017年 | 57篇 |
2016年 | 48篇 |
2015年 | 62篇 |
2014年 | 80篇 |
2013年 | 87篇 |
2012年 | 113篇 |
2011年 | 129篇 |
2010年 | 59篇 |
2009年 | 69篇 |
2008年 | 99篇 |
2007年 | 111篇 |
2006年 | 87篇 |
2005年 | 80篇 |
2004年 | 82篇 |
2003年 | 47篇 |
2002年 | 44篇 |
2001年 | 35篇 |
2000年 | 36篇 |
1999年 | 30篇 |
1998年 | 7篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 16篇 |
1991年 | 15篇 |
1990年 | 7篇 |
1989年 | 6篇 |
1988年 | 9篇 |
1987年 | 10篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 13篇 |
1981年 | 6篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1948条查询结果,搜索用时 46 毫秒
21.
A saccular aneurysm of the posterior inferior cerebellar artery lying in the fourth ventricle and an arteriovenous malformation in the cerebellum fed by the same artery are reported. Clipping of the neck of the aneurysm and total removal of the arteriovenous malformation were performed successfully during one stage. Review of the pertinent literature indicates that the aneurysm of the posterior inferior cerebellar artery originates from the peripheral portion of the artery when associated with arteriovenous malformation. The treatment is often surgical with good results in more than 80% of cases. A one-stage operation is the method of choice. Embolization is not without risk and can be attempted when the PICA's course allows easy catheterization. 相似文献
22.
23.
24.
Ziv Dadon Eli Ben-Chetrit Ofer Benjaminov Louay Taha Yonit Wiener-Well Daniel Belman Phillip D. Levin 《Clinical microbiology and infection》2021,27(4):635.e1-635.e4
ObjectiveTo assess the role of the computerized tomography (CT) scanner in cross-transmission of carbapenem-resistant Acinetobacter baumannii between hospitalized patients undergoing CT scan.MethodsA single-centre retrospective observational analysis of inpatients undergoing CT scans. Patient-unique CT scans were defined as ‘index cases’ (patients undergoing CT scan with carbapenem-resistant Acinetobacter baumannii (CRAB) colonization documented during the previous 60 days), ‘incident cases’ (patients found colonized with CRAB within 14 days following CT scan), and ‘negative cases’ (negative for CRAB before and after CT scan). CRAB acquisition was analysed by time interval between CT scan and CT scan of the prior index-case patient.ResultsAmongst 73 047 CT scans performed over 5 years, 4834 scans were performed within 12 hours of an index case. CRAB acquisition was detected in 20 patients (incident cases), including 16/2725 (5.8/1000 scans) who underwent CT scan within 6 hours of an index-case CT scan and 4/2109 (1.9/1000 scans) who had their CT scan 7–12 hours after the CT scan of an index-case patient (p 0.033, risk ratio 3.1, 95%CI 1.03–9.25). Patient characteristics for the two time periods were similar. While not the only significant predictor of CRAB acquisition (others included age and length of hospital stay prior to the CT scan), the time elapsed from an index case remained a significant predictor for CRAB acquisition on multivariate analysis (OR 0.84, 95%CI 0.74–0.95, p 0.007).ConclusionsPerforming a CT scan within 6 hours of a CT scan performed in a CRAB-positive patient was an independent predictor of CRAB acquisition, approximately tripling the risk. This probably reflects poor infection control practice in the CT suite. 相似文献
25.
26.
27.
Marwa A. Ahmed Heba M. Kamal Ahmed M. Taha Shimaa F. Abd -Allateef 《Pathophysiology》2018,25(2):151-156
Nicotine administration has been shown to increase the risk for cardiovascular diseases and death. The present study was designed to investigate the impact of nicotine administration on serum level tumor necrosis factor and cycloxygenase -2 (COX-2) expression mediated cardiac injury in rat off springs, and the possible protective effect of folic acid. Eighteen pregnant female rats were randomly divided into three groups, six animals each. Control group received the vehicle, nicotine group received a dose of nicotine 0.1?mg/kg body weight, daily with subcutaneous injection from day 3 of gestation until weaning on postnatal day 21. Nicotine treated group received daily oral supplementation with folic acid 200?mg/kg body weight by intragastric tube prior to injection of nicotine. In serum of the pups, levels of tumor necrosis factor (TNF), nitric oxide (NO), total antioxidant capacity (TAC) and malondialdehyde (MDA) were measured. Histopathological studies of cardiac tissues using hematoxylin-eosin (H&E) were carried out. The expression of COX-2 was evaluated using immunohistochemistry. Serum TNF and MDA were significantly increased, while serum NO and TAC were significantly decreased in nicotine group. Moreover, nicotine-exposed rats showed complete lysis of cardiac myocytes, marked cytoplasmic vacuolation of myocytes, muscle fibers show loss of striation and increased COX-2 expression. Concomitant folic acid administration resulted in a significant alleviation of biochemical and structural alteration-induced by nicotine. In conclusion, folic acid has a protective role against nicotine induced cardiac injury by reduction of COX-2 expression, decreasing TNF production and lipid peroxidation mediated cell injury. 相似文献
28.
Bizhan Helli Majid Mohammad Shahi Karim Mowla Mohammad Taha Jalali Hossein Khadem Haghighian 《Phytotherapy research : PTR》2019,33(9):2421-2428
Inflammation is one of the main characteristics of rheumatoid arthritis. Based on the antiinflammatory properties of sesame, this study was conducted to evaluate the sesamin supplement effects on serum levels of some proteolytic enzymes, inflammatory biomarkers, and clinical indices in women with rheumatoid arthritis. In this randomized, triple‐blind, placebo‐controlled clinical trial, 44 patients were randomly divided in intervention and control groups. Patients received 200‐mg/day sesamin supplement or placebo in the intervention and control group for 6 weeks. Serum levels of proteolytic enzymes (hyaluronidase, aggrecanase, and matrix metalloproteinases‐3) and inflammatory biomarkers (hs‐CRP, IL‐1β, IL‐6, TNF‐α, and cyclooxygenase‐2) were measured with enzyme‐linked immunosorbent assay method at the beginning and end of the study. After intervention, serum levels of hyaluronidase and matrix metalloproteinases‐3 decreased significantly in sesamin group. Also, serum levels of hs‐CRP, TNF‐α, and cyclooxygenase‐2 in intervention group were significantly decreased in intervention group compared with placebo group. Sesamin supplementation also caused a significant reduction in the number of tender joints and severity of pain in these patients. According to the results, it seems that the sesamin by reducing inflammatory mediators can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis. 相似文献
29.
Sule Caglayan Sozmen M.D. Sakine Isik M.D. Zeynep Arikan Ayyildiz M.D. Kaan Yildiz M.D. Yasemin Cakır M.D. Erdener Ozer M.D. Suna Asilsoy Nevin Uzuner Ozkan Karaman Ozden Anal 《Pediatric dermatology》2015,32(2):e54-e57
Omenn syndrome is a combined immunodeficiency characterized by a generalized erythematous skin rash, enlarged lymph nodes, hepatosplenomegaly, severe susceptibility to infections, eosinophilia, and hyperimmunoglobulinemia E. A 3‐month‐old girl was admitted to our hospital with a history of recurrent sepsis. Physical examination revealed severe erythroderma, hepatosplenomegaly, lymphadenopathy, and failure to thrive. Laboratory findings revealed leukocytosis, lymphocytosis with high CD3 T‐cells, a high CD4:CD8 ratio, absence of CD19 B‐cells, high eosinophil count, and low immunoglobulin levels. A heterozygote RAG1 gene mutation was found. She had itchy, scaling, ichthyosiform erythroderma and protracted diarrhea. Cyclosporin treatment up to 10 mg/kg effectively resolved erythroderma and lowered total eosinophil counts, and she gained weight during treatment. Since extensive erythroderma with generalized itching causes patient discomfort in Omenn syndrome, cyclosporin treatment can be considered while waiting for treatment with hematopoietic stem cell transplantation. 相似文献
30.