全文获取类型
收费全文 | 2417篇 |
免费 | 170篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 139篇 |
妇产科学 | 68篇 |
基础医学 | 365篇 |
口腔科学 | 74篇 |
临床医学 | 217篇 |
内科学 | 530篇 |
皮肤病学 | 51篇 |
神经病学 | 156篇 |
特种医学 | 64篇 |
外科学 | 271篇 |
综合类 | 28篇 |
一般理论 | 2篇 |
预防医学 | 144篇 |
眼科学 | 111篇 |
药学 | 152篇 |
中国医学 | 13篇 |
肿瘤学 | 200篇 |
出版年
2024年 | 4篇 |
2023年 | 50篇 |
2022年 | 79篇 |
2021年 | 141篇 |
2020年 | 91篇 |
2019年 | 118篇 |
2018年 | 142篇 |
2017年 | 111篇 |
2016年 | 105篇 |
2015年 | 80篇 |
2014年 | 119篇 |
2013年 | 164篇 |
2012年 | 227篇 |
2011年 | 197篇 |
2010年 | 138篇 |
2009年 | 80篇 |
2008年 | 149篇 |
2007年 | 135篇 |
2006年 | 113篇 |
2005年 | 83篇 |
2004年 | 97篇 |
2003年 | 69篇 |
2002年 | 59篇 |
2001年 | 6篇 |
2000年 | 7篇 |
1999年 | 5篇 |
1998年 | 9篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有2605条查询结果,搜索用时 15 毫秒
991.
992.
Jyotsna Bhatavdekar Devendra Patel Nandita Ghosh Hemangini Vora Neelam Shah Nilkamal Karelia Damodar Balar Priya Chikhlikar Ruchita Dave 《Journal of surgical oncology》1994,55(4):246-249
The prolactin receptors (PRLR) were correlated with circulating prolactin arious clinicopathologic parameters to investigate its prognostic value in patients with colorectal cancer. The prolactin (by radioimmunoassay) and its receptors (by radioligand method) were estimated in a total of 71 male patients with colorectal cancer enrolled at the Gujarat Cancer and Research Institute, Ahmedabad. The patients were followed for a period of 3 years. We have observed that 51% colorectal tumors were PRLR+. Significant correlation was not observed between presence/absence of PRLR and clinicopathologic variables. Dukes' D patients were lost to follow-up after 2–3 months; therefore, the results of prognostic significance were analysed only in patients with Dukes' A, B, and C (N = 64). Statistically significant difference in overall survival was not observed when the patients were subgrouped according to the presence/absence of PRLR and according to the cutoff level (i.e., 2%). PRLR+ hyperprolactinemic (Prolactin > 20.0 ng/ml plasma) patients had better overall survival than that of patients with PRLR? hyperprolactinemia, although the difference was statistically nonsignificant. However, PRLR? hyperprolactinemia patients had a more unfavourable prognosis than that of their counterparts. A similar trend was observed in patients with Dukes' B and C disease. Our preliminary study suggests an unequivocal finding, that PRLR?with concomitant hyperprolactinemia probably characterises a subgroup of patients with aggressive colorectal cancer. © Wiley-Liss, Inc. 相似文献
993.
Schwartzbaum Judith A. Lal Priya Evanoff Wendi Mamrak Sandra Yates Allan Barnett Gene H. Goodman Joseph Fisher James L. 《Journal of neuro-oncology》1999,43(1):35-41
To determine whether serum albumin levels, before first surgery, predict time until death, 24 glioblastoma multiforme patients newly diagnosed at Ohio State University and Cleveland Clinic Foundation Hospitals between 1993 and 1995 were followed until 1996. Patients with presurgical serum albumin levels below 3.4mg/dL survived an average (median) of 62 days (95% confidence interval (CI): 34, 135 days) after surgery. Those with serum albumin levels of at least 3.4mg/dL survived an average of 494 days (95% CI: 241, 624 days). The association between serum albumin level and time until death persists when adjusted for demographic and treatment variables using Cox proportional hazards regression. Adjusted hazard ratios, by quartile of presurgical serum albumin level, are: 1.0, 1.2, 0.1, 0.1 (P-value for trend test=0.007). In addition to providing a prognostic indicator, presurgical serum albumin levels can be used to evaluate the success of randomization of clinical trials for glioblastoma multiforme therapies. Our findings are consistent with results seen for tumors at other sites. We speculate that our results may be attributable to an association between low serum albumin levels and physiological events associated with angiogenesis. 相似文献
994.
Vishnu Priya Murali 《Immunopharmacology and immunotoxicology》2016,38(4):264-269
A positive modulation of immune system is necessary for preparing the body to fight against malignant tumor cells. In the present study, the stimulatory effect of Curculigoside on cell-mediated immune response against the metastasis of B16F10 melanoma cells was analyzed in C57BL/6 mice. Curculigoside is a phenolic glucoside present in the plant Curculigo orchioides Gaertn. (Family – Amaryllidaceae). Administration of Curculigoside enhanced the natural killer (NK) cell activity, antibody-dependent cell-mediated cytotoxicity and complement-mediated cytotoxicity in metastatic tumor-bearing animals, when compared to the untreated control animals. The compound was also found to be effective in reducing the levels of proinflammatory cytokines such as TNF-α, IL-1β, IL-6 and GM-CSF during metastasis. Besides these, levels of TH1 cytokines, such as IL-2 and IFN-γ, were significantly enhanced (p?0.001) by Curculigoside administration and thereby reduces the metastatic lung colony formation along with an increased lifespan of the experimental animals. These studies provide an evidence for the stimulation of cell-mediated immune responses by Curculigoside against B16F10-induced metastatic tumor progression in experimental animals. 相似文献
995.
996.
Girish?N.?NadkarniEmail author Priya?K.?Simoes Achint?Patel Shanti?Patel Rabi?Yacoub Ioannis?Konstantinidis Sunil?Kamat Narender?Annapureddy Chirag?R.?Parikh Steven?G.?Coca 《Hepatology International》2016,10(3):525-531
Background and aims
Cirrhosis affects 5.5 million patients with estimated costs of US$4 billion. Previous studies about dialysis requiring acute kidney injury (AKI-D) in decompensated cirrhosis (DC) are from a single center/year. We aimed to describe national trends of incidence and impact of AKI-D in DC hospitalizations.Methods
We extracted our cohort from the Nationwide Inpatient Sample (NIS) from 2006–2012. We identified hospitalizations with DC and AKI-D by validated ICD9 codes. We analyzed temporal changes in DC hospitalizations complicated by AKI-D and utilized multivariable logistic regression models to estimate AKI-D impact on hospital mortality.Results
We identified a total of 3,655,700 adult DC hospitalizations from 2006 to 2012 of which 78,015 (2.1 %) had AKI-D. The proportion with AKI-D increased from 1.5 % in 2006 to 2.23 % in 2012; it was stable between 2009 and 2012 despite an increase in absolute numbers from 6773 to 13,930. The overall hospital mortality was significantly higher in hospitalizations with AKI-D versus those without (40.87 vs. 6.96 %; p < 0.001). In an adjusted multivariable analysis, adjusted odds ratio for mortality was 2.17 (95 % CI 2.06–2.28; p < 0.01) with AKI-D, which was stable from 2006 to 2012. Changes in demographics and increases in acute/chronic comorbidities and procedures explained temporal changes in AKI-D.Conclusions
Proportion of DC hospitalizations with AKI-D increased from 2006 to 2009, and although this was stable from 2009 to 2012, there was an increase in absolute cases. These results elucidate the burden of AKI-D on DC hospitalizations and excess associated mortality, as well as highlight the importance of prevention, early diagnosis and testing of novel interventions in this vulnerable population.997.
Rufi?Tambe Pankaj?Jain Sachin?Patil Priya?Ghumatkar Sadhana?SathayeEmail author 《Naunyn-Schmiedeberg's archives of pharmacology》2016,389(5):467-475
Borneol, a bicyclic monoterpene, can easily cross the blood brain barrier and was found to possess gamma amino butyric acid (GABA) modulatory effect. The present study was aimed at investigating the antiepileptogenic effect of borneol in the pentylenetetrazole (PTZ)-induced kindling besides its ability to suppress oxidative stress and neuroinflammatory marker, glial fibrillary acidic protein (GFAP). Repeated administration of a subconvulsive dose of PTZ (35 mg/kg, i.p.) on every alternate day for 4 weeks produced kindling in mice. Borneol (5, 10, and 25 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.) were given as a pretreatment prior to each PTZ injection during the progression of kindling. Oxidative stress parameters such as superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT), and lipid peroxidation (LPO) were assessed at the end of the study. Neuronal damage was assessed by hematoxylin and eosin staining technique. GFAP was also evaluated in the hippocampus region of the brain by using immunohistochemistry. Borneol significantly suppressed the process of epileptogenesis in PTZ-kindled mice. The biochemical alterations induced by PTZ kindling were ameliorated in borneol-treated animals which was indicated by decreased LPO and increased SOD, GSH, CAT levels. The distinct neuronal damage observed in the kindled group was counteracted by borneol. Furthermore, it decreased the levels of GFAP which was manifested by reduced immunostaining. The above results are suggestive of the antiepileptogenic potential of borneol in the PTZ-induced kindling model of epilepsy, and thus, it could be a prospective molecule in the treatment of epilepsy. 相似文献
998.
Jimmy Flarakos Yancy Du Timothy Bedman Qusai Al-Share Pierre Jordaan Priya Chandra 《Xenobiotica; the fate of foreign compounds in biological systems》2016,46(11):986-1000
1.?Sacubitril/valsartan (LCZ696) is an angiotensin receptor neprilysin inhibitor (ARNI) providing simultaneous inhibition of neprilysin (neutral endopeptidase 24.11; NEP) and blockade of the angiotensin II type-1 (AT1) receptor.2.?Following oral administration, [14C]LCZ696 delivers systemic exposure to valsartan and AHU377 (sacubitril), which is rapidly metabolized to LBQ657 (M1), the biologically active neprilysin inhibitor. Peak sacubitril plasma concentrations were reached within 0.5–1?h. The mean terminal half-lives of sacubitril, LBQ657 and valsartan were ~1.3, ~12 and ~21?h, respectively.3.?Renal excretion was the dominant route of elimination of radioactivity in human. Urine accounted for 51.7–67.8% and feces for 36.9 to 48.3 % of the total radioactivity. The majority of the drug was excreted as the active metabolite LBQ657 in urine and feces, total accounting for ~85.5% of the total dose.4.?Based upon in vitro studies, the potential for LCZ696 to inhibit or induce cytochrome P450 (CYP) enzymes and cause CYP-mediated drug interactions clinically was found to be low. 相似文献
999.
1000.
Intratumoral heterogeneity: Role of differentiation in a potentially lethal phenotype of testicular cancer
下载免费PDF全文
![点击此处可从《Cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shi‐Ming Tu MD Mehmet Asim Bilen MD Kenneth R. Hess PhD Russell R. Broaddus MD Scott Kopetz MD PhD Chongjuan Wei PhD Lance C. Pagliaro MD Jose A. Karam MD John F. Ward MD Christopher G. Wood MD Priya Rao MD Zachary H. Tu Rosale General APRN Adrienne H. Chen PharmD Yago L. Nieto MD PhD Sai‐ching J. Yeung MD PhD Sue‐Hwa Lin PhD Christopher J. Logothetis MD Louis L. Pisters MD 《Cancer》2016,122(12):1836-1843