全文获取类型
收费全文 | 1177篇 |
免费 | 69篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 31篇 |
妇产科学 | 21篇 |
基础医学 | 131篇 |
口腔科学 | 11篇 |
临床医学 | 93篇 |
内科学 | 256篇 |
皮肤病学 | 12篇 |
神经病学 | 76篇 |
特种医学 | 32篇 |
外科学 | 233篇 |
综合类 | 22篇 |
预防医学 | 31篇 |
眼科学 | 108篇 |
药学 | 123篇 |
中国医学 | 6篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 4篇 |
2022年 | 25篇 |
2021年 | 76篇 |
2020年 | 27篇 |
2019年 | 29篇 |
2018年 | 26篇 |
2017年 | 19篇 |
2016年 | 37篇 |
2015年 | 39篇 |
2014年 | 55篇 |
2013年 | 55篇 |
2012年 | 83篇 |
2011年 | 87篇 |
2010年 | 47篇 |
2009年 | 48篇 |
2008年 | 65篇 |
2007年 | 63篇 |
2006年 | 85篇 |
2005年 | 58篇 |
2004年 | 45篇 |
2003年 | 46篇 |
2002年 | 33篇 |
2001年 | 10篇 |
2000年 | 17篇 |
1999年 | 11篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 12篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 15篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 7篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1980年 | 4篇 |
1976年 | 4篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1971年 | 3篇 |
1970年 | 3篇 |
1969年 | 6篇 |
排序方式: 共有1249条查询结果,搜索用时 15 毫秒
81.
82.
Continuous subcutaneous insulin infusion and multiple daily injection therapy are equally effective in type 2 diabetes: a randomized,parallel-group, 24-week study 总被引:16,自引:0,他引:16
Raskin P Bode BW Marks JB Hirsch IB Weinstein RL McGill JB Peterson GE Mudaliar SR Reinhardt RR 《Diabetes care》2003,26(9):2598-2603
OBJECTIVE: Compare the efficacy, safety, and patient satisfaction of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy for patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 132 CSII-naive type 2 diabetic patients were randomly assigned (1:1) to CSII (using insulin aspart) or MDI therapy (bolus insulin aspart and basal NPH insulin) in a multicenter, open-label, randomized, parallel-group, 24-week study. Efficacy was assessed with HbA(1c) and eight-point blood glucose (BG) profiles. Treatment satisfaction was determined with a self-administered questionnaire. Safety assessments included adverse events, hypoglycemic episodes, laboratory values, and physical examination findings. RESULTS: HbA(1c) values decreased similarly for both groups from baseline (8.2 +/- 1.37% for CSII, 8.0 +/- 1.08% for MDI) to end of study (7.6 +/- 1.22% for CSII, 7.5 +/- 1.22% for MDI). The CSII group showed a trend toward lower eight-point BG values at most time points (only significant 90 min after breakfast; 167 +/- 48 vs. 192 +/- 65 mg/dl for CSII and MDI, respectively; P = 0.019). A total of 93% of CSII-treated subjects preferred the pump to their previous injectable insulin regimen for reasons of convenience, flexibility, ease of use, and overall preference. Safety assessments were comparable for both treatment groups. CONCLUSIONS: Insulin aspart in CSII therapy provided efficacy and safety comparable to MDI therapy for type 2 diabetes. Patients with type 2 diabetes can be trained as outpatients to use CSII and prefer CSII to injections, indicating that pump therapy should be considered when initiating intensive insulin therapy for type 2 diabetes. 相似文献
83.
Shyam Sunder 《Postgraduate medicine》2013,125(1):334-337
84.
85.
Repeat regions of malaria parasite proteins: a review of structure and possible role in the biology of the parasite. 总被引:1,自引:0,他引:1
R Ramasamy 《Indian journal of malariology》1991,28(2):73-81
Tandemly repeated amino acid sequences are characteristic of many malaria parasite proteins that have been sequenced to date. Strong selective pressures must exist to maintain the repeat regions and also to diversify them in the case proteins containing strain-variant repeats. Repeats have been suggested to function in immune-evasion and in binding to host receptors. This article focuses on the structural characteristics of the repeats in relation to their postulated function. 相似文献
86.
87.
Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects. 总被引:11,自引:0,他引:11
Theodore P Ciaraldi Alice P S Kong Neelima V Chu Dennis D Kim Sunita Baxi Mattias Loviscach Ray Plodkowski Richard Reitz Michael Caulfield Sunder Mudaliar Robert R Henry 《Diabetes》2002,51(1):30-36
Type 2 diabetic subjects failing glyburide therapy were randomized to receive additional therapy with either metformin (2,550 mg/day) or troglitazone (600 mg/day) for 3-4 months. Biopsies of subcutaneous abdominal adipose tissue were obtained before and after therapy. Glycemic control was similar with both treatments. Metformin treatment increased insulin-stimulated whole-body glucose disposal rates by 20% (P < 0.05); the response to troglitazone was greater (44% increase, P < 0.01 vs. baseline, P < 0.05 vs. metformin). Troglitazone-treated subjects displayed a tendency toward weight gain (5 +/- 2 kg, P < 0.05), increased adipocyte size, and increased serum leptin levels. Metformin-treated subjects were weight-stable, with unchanged leptin levels and reduced adipocyte size (to 84 +/- 4% of control, P < 0.005). Glucose transport in isolated adipocytes from metformin-treated subjects was unaltered from pretreatment. Glucose transport in both the absence (321 +/- 134% of pre-Rx, P < 0.05) and presence of insulin (418 +/- 161%, P < 0.05) was elevated after troglitazone treatment. Metformin treatment had no effect on adipocyte content of GLUT1 or GLUT4 proteins. After troglitazone treatment, GLUT4 protein expression was increased twofold (202 +/- 42%, P < 0.05). Insulin-stimulated serine phosphorylation of Akt was augmented after troglitazone (170 +/- 34% of pre-Rx response, P < 0.05) treatment and unchanged by metformin. We conclude that the ability of troglitazone to upregulate adipocyte glucose transport, GLUT4 expression, and insulin signaling can contribute to its greater effect on whole-body glucose disposal. 相似文献
88.
89.
90.
Dirty‐Appearing White Matter in the Brain is Associated with Altered Cerebrospinal Fluid Pulsatility and Hypertension in Individuals without Neurologic Disease
下载免费PDF全文
![点击此处可从《Journal of neuroimaging》网站下载免费的PDF全文](/ch/ext_images/free.gif)