Increase in sex-dependent expression of prolactin receptors after intrahepatic transplantation of H27 rat hepatoma cells

Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation). __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 3, pp. 276–279, March, 2007     

Population models in the study of the neurogenic determinants of arterial hypertension. Report I. Peculiarities of arterial hypertension in schizophrenia

In order to clarify the role of the central nervous system in the genesis of arterial hypertension (AH) a population analysis of somatic pathology in schizophrenia was performed. Using clinical and postmortem data, the study found lower frequency of AH among mental patients vs. somatic ones; primary AH was benign independently of the psychotropic therapy regimen. II to III stage AH in psychosis was associated with primary or secondary renal pathology or magistral vessel atherosclerosis. Severe schizophrenia and a pronounced personality defect were associated with low intensity of the primary form of somatic nosology.     

Quantitative HPLC Determination of γ-Aminobutyric Acid Derivative Mefebut in Bioassays

Pharmaceutical Chemistry Journal - A quantitative HPLC method was developed for analyzing mefebut in pharmacokinetic studies. The method was highly sensitive and selective and could be used for...     

肿瘤相关基因Cap43在胰腺癌中的表达及意义

目的研究肿瘤相关基因Cap43在胰腺癌组织中的表达情况,探讨其对胰腺癌的诊断价值。方法收集1999年4月～2002年8月长海医院外科手术切除胰腺癌标本和癌旁正常组织33例,诊断均由病理证实。男性22例,女性11例,年龄30～73岁,平均58．1岁。所有组织标本按肿瘤、癌旁(正常)配对。采用RT-PCR和Northern杂交方法研究Cap43 mRNA表达情况。结果 RT-PCR结果显示,Cap43在肿瘤组织中表达显著上调,其在肿瘤组织和癌旁正常组织的扫描值分别为4 033±1 986和2 244±1 145,有显著差异(P<0．001)。Northern杂交亦显示Cap43在肿瘤组织中表达显著上调,相同病例的RT-PCR结果与Northern杂交的结果有较好的一致性,经回归分析,没有显著性差异(P>0．1)。结论 Cap43在胰腺癌组织中呈显著高表达,其有可能成为胰腺癌早期诊断的重要标志物。     

Determination of sialic acids in the nasal mucosa lavage

A modified method of determining the sialic acids by using Ehrlich's reagent and according to G. Sydow (1985) was worked out; the method is characterized by a higher sensitivity as compared to the unified methods of Hess and Svennerholm, which enables to process the nasal mucous lavage that has an essentially lower concentration of sialic acids than the blood serum. A clinical approbation of the modified method (in patients with bronchial asthma, and with obstructive and non-obstructive bronchitis) showed that it preserved the specificity typical of the original method and is sufficiently sensitive. Examinations of 12 healthy volunteers showed that the concentration of sialic acids in their lavage amounted to 0.110 +/- 0.012 mumol/L.     

Comorbidity of ulcerative erosive lesions of the gastroduodenal area and arterial hypertension

Comorbidity remains an important scientific and practical medical problem especially in respect to such prevalent and socially significant diseases as arterial hypertension (AH) and ulcerative-erosive gastroduodenal lesions (UEGDL). In these diseases there are common etiological and pathogenetic factors reflecting syntropy of this combination. These factors include systemic vascular disorders, homeostatic alterations, immunological disturbances, mental diseases, metabolic syndrome, impairment of cellular membranes as a result of activation of lipid peroxidation, etc. Adequate therapy is essential in AH comorbidity with UEGDL. It should be directed not only to lowering of blood pressure and local pathogenetic factors (acidopeptic, infectious, vascular) but also predict pharmacological impact on both diseases and other risk factors to reduce probability of unfavourable outcomes, correct damaged mechanisms of adaptive regulation of the organism and improve quality of patients' life. Specificity of the comorbide course of AH and UEGDL should be considered to perform adequate treatment, goal-oriented prevention and prediction of complications.