Mechanism of action of baclofen on myocardial and vascular contractility

Department of Anatomy and Physiology of Man and Animals, A. I. Gertsen Leningrad Pedagogic Institute. Department of Pharmacology, Academician I. P. Pavlov First Leningrad Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. V. Val'dman.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 106, No. 10, pp. 436–438, October, 1988.     

Mortality, morbidity, lethality and the cardiovascular risk profile in the population of Novosibirsk]

The authors analyze the results of investigations in accordance with the WHO program "MONICA" in one of the districts of Novosibirsk. The bases of the objective information system pertaining to the tendencies in mortality, morbidity and lethality due to cardiovascular diseases, the prevalence of risk factors in the population, the possibilities of their monitoring have been established.     

Synthesis of water-soluble polymeric esters of the antibiotic cefuroxime

Water-soluble polymeric esters of the antibiotic cefuroxime were synthesized for the first time by the carbodiimide method using low-molecular-weight poly-(N-2-hydroxypropyl)methacrylamide as a carrier. The synthesized compounds contain 16.6 and 19.5 wt% antibiotic, exhibit antibacterial activity with respect to S. aureus, and are subject to hydrolysis in physiological solution at 37°C (45.4 and 53.2% for 24 and 30 h, respectively).     

Increase in sex-dependent expression of prolactin receptors after intrahepatic transplantation of H27 rat hepatoma cells

Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation). __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 3, pp. 276–279, March, 2007