全文获取类型
收费全文 | 1792篇 |
免费 | 84篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 37篇 |
妇产科学 | 101篇 |
基础医学 | 210篇 |
口腔科学 | 3篇 |
临床医学 | 169篇 |
内科学 | 538篇 |
皮肤病学 | 56篇 |
神经病学 | 101篇 |
特种医学 | 41篇 |
外科学 | 161篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 56篇 |
眼科学 | 57篇 |
药学 | 173篇 |
中国医学 | 58篇 |
肿瘤学 | 97篇 |
出版年
2023年 | 5篇 |
2022年 | 5篇 |
2021年 | 24篇 |
2020年 | 14篇 |
2019年 | 22篇 |
2018年 | 33篇 |
2017年 | 13篇 |
2016年 | 20篇 |
2015年 | 43篇 |
2014年 | 51篇 |
2013年 | 72篇 |
2012年 | 124篇 |
2011年 | 98篇 |
2010年 | 91篇 |
2009年 | 65篇 |
2008年 | 101篇 |
2007年 | 149篇 |
2006年 | 135篇 |
2005年 | 119篇 |
2004年 | 88篇 |
2003年 | 84篇 |
2002年 | 86篇 |
2001年 | 85篇 |
2000年 | 55篇 |
1999年 | 62篇 |
1998年 | 27篇 |
1997年 | 13篇 |
1996年 | 15篇 |
1995年 | 11篇 |
1994年 | 16篇 |
1993年 | 9篇 |
1992年 | 28篇 |
1991年 | 25篇 |
1990年 | 24篇 |
1989年 | 7篇 |
1988年 | 14篇 |
1987年 | 19篇 |
1986年 | 7篇 |
1985年 | 13篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
排序方式: 共有1886条查询结果,搜索用时 78 毫秒
31.
Dean Wu Jehn-Shing Sheu Hsing-Cheng Liu Rey-Yue Yuan Jia-Ming Yu Jau-Jiuan Sheu Chia-Hsiu Hung Chaur-Jong Hu 《Clinical biochemistry》2012,45(16-17):1316-1319
ObjectivesToll-like receptors (TLRs) are molecules conserved in evolution for detecting pathogen invasions and tissue damage and are involved in atherogenesis. This study explores the mRNA expression of TLRs and their probable role in further disease occurrence among ischemic stroke patients.Design and MethodsA total of 89 ischemic stroke patients and 166 controls were recruited for this study. Total RNA was extracted and mRNA was reverse-transcribed to cDNA and was analyzed for TLRs and interleukin 8 (IL8).ResultsThe TLR4 mRNA expression level is significantly higher in the stroke group. Conversely, IL-8 mRNA levels decreased significantly in the patient group.ConclusionOur results suggest that TLR4 overexpression in mRNA levels is observed in stroke patients, which might account for the probable inflammatory injury before or after stroke. A reduction of IL-8 expression could result from the downregulatory effects of aspirin. 相似文献
32.
33.
34.
35.
36.
Eric E. Beier Jason A. Inzana Tzong-Jen Sheu Lei Shu J. Edward Puzas Robert A. Mooney 《Environmental health perspectives》2015,123(10):935-943
Background
Lead (Pb) exposure and obesity are co-occurring risk factors for decreased bone mass in the young, particularly in low socioeconomic communities.Objectives
The goal of this study was to determine whether the comorbidities of Pb exposure and high-fat diet–induced obesity amplify skeletal deficits independently associated with each of these risk factors, and to explore associated mechanisms of the observed deficiencies.Methods
Five-week-old male C57BL/6J mice were placed on low-fat (10% kcal, LFD) or high-fat (60% kcal, HFD) diets for 12 weeks. Mice were exposed to lifetime Pb (50 ppm) through drinking water.Results
HFD was associated with increased body mass and glucose intolerance. Both HFD and Pb increased fasting glucose and serum leptin levels. Pb and HFD each reduced trabecular bone quality and together had a further detrimental effect on these bone parameters. Mechanical bone properties of strength were depressed in Pb-exposed bones, but HFD had no significant effect. Both Pb and HFD altered progenitor cell differentiation, promoting osteoclastogenesis and increasing adipogenesis while suppressing osteoblastogenesis. In support of this lineage shift being mediated through altered Wnt signaling, Pb and non-esterified fatty acids in MC3T3 cells increased in vitro PPAR-γ activity and inhibited β-catenin activity. Combining Pb and non-esterified fatty acids enhanced these effects.Conclusions
Pb and HFD produced selective deficits in bone accrual that were associated with alterations in progenitor cell activity that may involve reduced Wnt signaling. This study emphasizes the need to assess toxicants together with other risk factors relevant to human health and disease.Citation
Beier EE, Inzana JA, Sheu TJ, Shu L, Puzas JE, Mooney RA. 2015. Effects of combined exposure to lead and high-fat diet on bone quality in juvenile male mice. Environ Health Perspect 123:935–943; http://dx.doi.org/10.1289/ehp.1408581 相似文献37.
38.
Shwu-Jiuan Sheu Yao-Shen Chen Huey-Shyan Lin Shih-Lin Chen Pei-Jan Tsai 《Taiwan Journal of Ophthalmology》2015,5(1):23-27
Purpose:
The purpose of this study is to identify the possible factors for preserving the eyes after late or suboptimally treated endogenous endophthalmitis secondary to Klebsiella pneumoniae (KP) liver abscess.Methods:
A retrospective chart review was conducted for patients admitted with KP liver abscess from January 1991 to June 2012.Results:
Six hundred and ninety-three patients with KP liver abscess were recorded, in which endophthalmitis was identified in 53 cases (65 eyes, 8.29%). Diabetes was significantly associated with the development of endophthalmitis (p = 0.014). Eleven eyes received their last ocular treatment ≥10 days and final vision ≥ counting fingers, and were defined as benign type KP endophthalmitis. The absence of diabetes was the only consistent candidate factor for benign type KP endophthalmitis.Conclusion:
A lack of ongoing diabetes is an important factor in preserving eyes with late or suboptimally treated endogenous endophthalmitis second to KP liver abscess. 相似文献39.
Lin TH Huang CH Voon WC Yen HW Lai HM Liang HY Lu YH Lee KT Lee CS Lai WT Sheu SH 《The Kaohsiung journal of medical sciences》2000,16(12):600-606
Several studies have shown cardiovascular benefit in treating hypercholesterolemia with HMG-CoA reductase inhibitor. However, in addition to the lowering of cholesterol, the beneficial effects of this inhibitor reflect other pharmacological activities. Whether these beneficial effects are partly mediated by changes in fibrinolytic factors remains to be proven, since clinical studies on the effects of HMG-CoA reductase inhibitors on fibrinolytic factors have not yielded consistent results. The purpose of this study was to evaluate the effects of fluvastatin on fibrinolytic factors in hypercholesterolemic patients. After 6 weeks on a low-fat, low-cholesterol diet, 23 outpatients known to have primary hypercholesterolemia with low density lipoprotein cholesterol (LDL-C) > or = 130 mg/dl with at least 2 risk factors or fasting LDL-C > or = 160 mg/dl were selected for the study. Venous blood samples were collected at baseline and at 8 weeks after fluvastatin therapy (40 mg/day) to measure of tissue plasminogen activator (t-PA), plasminogen activators inhibitor-1 (PAI-1), fibrinogen, D-dimer and lipid profile. After 8 weeks of therapy, fluvastatin reduced serum cholesterol by 11% (261.9 mg/dl vs 233.2 mg/dl, P < 0.01) and LDL-C by 22% (191.9 mg/dl vs 149.3 mg/dl, P < 0.01). D-dimer was significantly decreased (0.38 ng/L vs 0.28 ng/L, P = 0.02) and tPA, PAI-1 and fibrinogen tended to decrease after therapy. Fluvastatin therapy improved fibrinolytic profile; the result of this study may in part explain the benefit of HMG-CoA reductase inhibitor on cardiovascular system other than lipid lowering. 相似文献
40.
G T Huang P M Yang J C Sheu H C Hsu J L Sung T H Wang D S Chen 《Hepato-gastroenterology》1990,37(5):452-456
Intratumor injection of OK-432, a biological response modifier, in the treatment of small HCC was studied in 7 inoperable patients. After evaluation with ultrasound (US), computed tomography (CT), angiography and US-guided biopsy, implantation of a steel coil in the tumor, intratumor injection was performed under US guidance. After completion of the treatment, liver biopsy and image studies were again done to evaluate the extent of tumor necrosis. One patient was alive and well without recurrence 19 months after treatment. Four had recurrent tumors at different site of the liver 4 months, 9 months, 9 months and 8 months later. Two died of progressive malignancy 3 months and 8 months later. In the 6 patients with elevated serum alpha-fetoprotein (AFP) levels, 4 had decreased AFP after treatment, and the 2 mortalities had steadily increased AFP. The most common side effects are fever and chills. Transient abdominal pain with elevated transaminase activities, cough with hemoptysis, and vomiting were seen in 1 case each. After treatment, the biopsy specimens showed total necrosis of HCC. Although the T4/T8 ratio of peripheral blood was increased as compared with that before treatment in 4 cases, peritumoral cytotoxic T lymphocyte and monocyte infiltration were seen in one specimen only, and another 7 examined specimens showed negative staining with monoclonal antibodies of T cells. We conclude that intratumor injection of OK-432 is an alternative treatment for small HCC in inoperable cases. The effectiveness may be due to the direct tumoricidal mechanism of OK-432. 相似文献