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Ledipasvir/sofosbuvir fixed‐dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus 下载免费PDF全文
Wan‐Long Chuang Rong‐Nan Chien Cheng‐Yuan Peng Ting‐Tsung Chang Gin‐Ho Lo I‐Shyan Sheen Horng‐Yuan Wang Jyh‐Jou Chen Jenny C. Yang Steven J. Knox Bing Gao Kimberly L. Garrison Hongmei Mo Phillip S. Pang Yu‐Chun Hsu Tsung‐Hui Hu Chi‐Jen Chu Jia‐Horng Kao 《Journal of gastroenterology and hepatology》2016,31(7):1323-1329
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Yi Wei Goh MBChB Charles NJ McGhee PhD FRCOphth Dipika V Patel PhD MRCOphth Rachel Barnes MBChB FRANZCO Stuti Misra MSc BOptom 《Clinical & experimental optometry》2014,97(3):274-277
Traditionally, photodynamic therapy (PDT) has been used to treat choroidal neovascularisation. More recently, its use in corneal neovascularisation has provided promising clinical results. The major advantage of PDT is that it is minimally invasive, resulting in closure of the neovascular network without damaging the surrounding healthy tissue. This report describes the positive results of PDT, clinically and microstructurally, as imaged by in vivo confocal microscopy, for treating corneal neovascularisation with lipid keratopathy, secondary to herpes zoster infection. 相似文献
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Ming‐Chun Hsu Jau‐Yu Liau Jin‐Liern Hong Yin Cheng Yi‐Hua Liao Jau‐Shiuh Chen Yi‐Shuan Sheen Jin‐Bon Hong 《The Journal of dermatology》2016,43(2):175-180
Nevus sebaceus is frequently associated with the development of secondary neoplasms. Incidences of malignant transformation vary among different reports and few data is available regarding Asian populations. We aimed to determine the characteristics of secondary tumors developing from nevus sebaceus in a Taiwanese population and to review the published work. Patients with clinically and histologically confirmed nevus sebaceus were identified from 1992 to 2012 in a medical center. Among the 450 cases of nevus sebaceus, 38 secondary neoplasms were noted, accounting for 8.5% of all cases. Benign tumors represented more than 80% of all tumors. Syringocystadenoma papilliferum (2.7%) was the most common benign tumor, followed by trichoblastoma (1.6%) and trichilemmoma (1.6%) whereas basal cell carcinoma (0.9%) was the most frequent malignant tumor on nevus sebaceus and its clinical features were not typical. All the malignant tumors on nevus sebaceus were noted only in adulthood and the mean age of those with basal cell carcinoma was significantly older than that of trichoblastoma (P = 0.028). Our study concludes that malignant transformation is rare in nevus sebaceus and occurs uniquely in adulthood. On the basis of the findings, prophylactic excision of nevus sebaceus can be elective during childhood but is strongly advocated at puberty due to the increased risk of malignant transformation with time. 相似文献
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Interaction between 25‐hydroxyvitamin D and variants at 17q12‐21 on respiratory infections 下载免费PDF全文
Youn Ho Sheen MD PhD Eun Lee MD PhD Mi‐Jin Kang PhD Ho‐Sung Yu MS Kangmo Ahn MD PhD Kyung Won Kim MD PhD Song‐I Yang MD Young‐Ho Jung MD Kyung‐Ju Lee MD PhD Hyoung Yoon Chang MD PhD Hye Lim Shin BS Kil Yong Choi BS Hyung Young Kim MD Ju‐Hee Seo MD Ji‐Won Kwon MD Byoung‐Ju Kim MD PhD Hyo‐Bin Kim MD PhD So‐Yeon Lee MD PhD Dong In Suh MD Hyeon‐Jong Yang MD PhD Suk‐Joo Choi MD PhD Soo‐Young Oh MD PhD Ja‐Young Kwon MD PhD Soo Hyun Kim MD Hye‐Sung Won MD PhD Eun‐Jin Kim PhD Jeom Kyu Lee PhD Soo‐Jong Hong MD PhD 《Pediatric pulmonology》2016,51(9):958-967
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Victoria Sheen Heajung Nguyen Melissa Jimenez Vatche Agopian Sitaram Vangala David Elashoff Sammy Saab 《临床与转化肝病杂志(英文版)》2016,4(1):20-25
Background and Aims: The aims of our study were to determine whether routine blood tests, the aspartate aminotransferase (AST) to Platelet Ratio Index (APRI) and Fibrosis 4 (Fib-4) scores, were associated with advanced fibrosis and to create a novel model in liver transplant recipients with chronic hepatitis C virus (HCV). Methods: We performed a cross sectional study of patients at The University of California at Los Angeles (UCLA) Medical Center who underwent liver transplantation for HCV. We used linear mixed effects models to analyze association between fibrosis severity and individual biochemical markers and mixed effects logistic regression to construct diagnostic models for advanced fibrosis (METAVIR F3-4). Cross-validation was used to estimate a receiving operator characteristic (ROC) curve for the prediction models and to estimate the area under the curve (AUC). Results: The mean (± standard deviation [SD]) age of our cohort was 55 (±7.7) years, and almost three quarter were male. The mean (±SD) time from transplant to liver biopsy was 19.9 (±17.1) months. The mean (±SD) APRI and Fib-4 scores were 3 (±12) and 7 (±14), respectively. Increased fibrosis was associated with lower platelet count and alanine aminotransferase (ALT) values and higher total bilirubin and Fib-4 scores. We developed a model that takes into account age, gender, platelet count, ALT, and total bilirubin, and this model outperformed APRI and Fib-4 with an AUC of 0.68 (p < 0.001). Conclusions: Our novel prediction model diagnosed the presence of advanced fibrosis more reliably than APRI and Fib-4 scores. This noninvasive calculation may be used clinically to identify liver transplant recipients with HCV with significant liver damage. 相似文献