全文获取类型
收费全文 | 16057篇 |
免费 | 1807篇 |
国内免费 | 1164篇 |
专业分类
耳鼻咽喉 | 132篇 |
儿科学 | 348篇 |
妇产科学 | 218篇 |
基础医学 | 1640篇 |
口腔科学 | 224篇 |
临床医学 | 2156篇 |
内科学 | 2283篇 |
皮肤病学 | 199篇 |
神经病学 | 727篇 |
特种医学 | 489篇 |
外国民族医学 | 3篇 |
外科学 | 1585篇 |
综合类 | 3123篇 |
现状与发展 | 7篇 |
一般理论 | 2篇 |
预防医学 | 1314篇 |
眼科学 | 322篇 |
药学 | 1842篇 |
24篇 | |
中国医学 | 1178篇 |
肿瘤学 | 1212篇 |
出版年
2024年 | 78篇 |
2023年 | 291篇 |
2022年 | 729篇 |
2021年 | 916篇 |
2020年 | 736篇 |
2019年 | 602篇 |
2018年 | 591篇 |
2017年 | 612篇 |
2016年 | 575篇 |
2015年 | 794篇 |
2014年 | 960篇 |
2013年 | 990篇 |
2012年 | 1366篇 |
2011年 | 1478篇 |
2010年 | 980篇 |
2009年 | 843篇 |
2008年 | 949篇 |
2007年 | 839篇 |
2006年 | 768篇 |
2005年 | 657篇 |
2004年 | 514篇 |
2003年 | 565篇 |
2002年 | 425篇 |
2001年 | 356篇 |
2000年 | 278篇 |
1999年 | 255篇 |
1998年 | 132篇 |
1997年 | 140篇 |
1996年 | 96篇 |
1995年 | 82篇 |
1994年 | 90篇 |
1993年 | 56篇 |
1992年 | 55篇 |
1991年 | 44篇 |
1990年 | 38篇 |
1989年 | 39篇 |
1988年 | 30篇 |
1987年 | 18篇 |
1986年 | 18篇 |
1985年 | 14篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1975年 | 2篇 |
1973年 | 1篇 |
1966年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
金黄色葡萄球菌儿童株耐药性分析 总被引:2,自引:0,他引:2
目的 了解儿童中金黄色葡萄球菌所致疾病的分布及其对常用抗生素的敏感情况。方法 收集连续12个月的临床致病株,根据菌落形态、革兰染色特点和乳胶凝集实验对金黄色葡萄球菌进行初步筛选,用细菌自动鉴定系统Vitek GPI卡和GPS-101卡进行菌株鉴定和药敏试验。结果 分离到金黄色葡萄球菌145株,其中来自呼吸道感染患儿痰或咽拭子培养109株,占75.17%,来自血培养16株,占11.03%,来自脓液、阴道分泌物培养分别占6.21%和5.51%。药敏试验显示92.4l%的菌株产生β-内酰胺酶,96.55%的菌株对青霉素耐药,但耐苯唑西林的仅占6.21%。99.31%和100%的菌株分别对利福平和万古霉素敏感,对环丙沙星、阿莫西林/棒酸、头孢唑林、复方新诺明、庆大霉素和林可霉素的敏感率分别为95.86%、93.10%、92.41%、86.21%、84.83%和80.69%,37.93%的菌株对红霉素耐药。结论金黄色葡萄球菌常引起儿童呼吸道感染,对苯唑西林的耐药率低.该药仍是治疗小儿会黄色葡萄球菌感染的有效药物。 相似文献
82.
现代化医院呼唤现代服务模式 总被引:1,自引:0,他引:1
当前我们正在向建设基本现代化医院迈进,在注意硬件建设的同时,不要忽略软件建设。硬件建设需要大量投入,较易见成果;而后者无需大量财力投入,只需转变医院人的思想观念,就能使医院明显改观。 相似文献
83.
Anatomic and spiral computed tomographic study of the genial tubercles for genioglossus advancement.
Shan Kai Yin Hong Liang Yi Wen Ying Lu Jian Guan Hong Min Wu Zhen Yu Cao Dong Zhen Yu Yan Yan Huang Chun Gen Wu 《Otolaryngology--head and neck surgery》2007,136(4):632-637
OBJECTIVE: To measure and compare Chinese mandibular genial tubercles measured anatomically and with computed tomography (CT). STUDY DESIGN AND SETTING: Spiral CT scans were taken of 40 adult human skulls; the superior genial spines were measured using anatomic and CT methods. RESULTS: The height and width of the superior genial spines, mandible thickness, and distance from the menton to the inferior and superior margins of the superior genial spines were 5.82 +/- 0.71, 6.98 +/- 1.35, 11.95 +/- 1.59, 11.08 +/- 2.05, and 16.91 +/- 2.30 mm from anatomic measurements and 6.17 +/- 0.71, 7.01 +/- 1.13, 12.19 +/- 1.64, 10.41 +/- 1.55, and 15.73 +/- 2.12 mm using spiral CT, respectively. The anatomic and CT measurements were correlated. CONCLUSION: Spiral CT of the genial tubercles can help locate the osteotomy in genioglossus advancement. SIGNIFICANCE: This study acquired reference data on Chinese genial tubercles demonstrating that CT measurements of the genial tubercles reflect their anatomy, which should allow accurately locate the osteotomy. 相似文献
84.
85.
Ngai Suk Wai; Tang Oi Shan; Lao Terence; Ho Pak Chung; Ma Ho Kei 《Human reproduction (Oxford, England)》1995,10(5):1220-1222
Intravaginal misoprostol has been shown to be effective forcervical priming before a surgically induced abortion. The objectivewas to investigate the effectiveness of oral misoprostol incervical dilatation prior to vacuum aspiration between the 6thand 12th weeks of pregnancy. The results showed that in nulliparouspatients, the median cervical dilatation in the treatment group(7.8 mm) was significantly greater than that in the placebogroup (3.7 mm). In multiparous patients, the difference wasalso statistically significant (9.8 versus 6.0 mm). The easeof dilatation, assessed subjectively by the operating surgeons,was significantly improved in the treatment group. There wasalso a significant reduction in the duration of the operationand in the mean blood loss in the treatment group. The side-effectsencountered in the treatment group were mild and well acceptedby the women. Oral misoprostol is an effective and safe methodfor cervical dilatation prior to vacuum aspiration in firsttrimester pregnancy. 相似文献
86.
我院多年来应用千捶膏和生肌玉红膏治疗感染性伤面。千捶膏用于去腐,生肌玉红膏用于生新。据我们观察二药有较强的抗感染作用,尤其有抗绿脓感染作用。应用千捶膏可以较快地达到脱腐作用,应用生肌玉红膏可以促进肉芽增生,达到伤面早期愈合,值得推广。 相似文献
87.
目的 探究经颅多普勒超声(transcranial Doppler sonography, TCD)结合经颅彩色多普勒超声(transcranial color-coded duplex, TCCD)与数字减影血管造影(digital subtraction angiography, DSA)对脑动脉狭窄的一致性分析及对治疗方案的指导价值。方法 选取缺血性脑血管病患者100例,均行TCD、TCCD及DSA检查,以DSA检查结果作为“金标准”,分析脑动脉狭窄程度,观察不同狭窄程度患者TCD、TCCD超声表现,采用Kappa检验分析TCD结合TCCD诊断脑动脉狭窄程度与DSA检查结果的一致性,比较不同狭窄程度患者收缩期峰流速(systolic velocity, Vs)、平均峰流速(mean velocity, Vm)、搏动指数(pulsatility index, PI),采用Spearman相关系数模型分析Vm、PI与脑动脉狭窄程度的相关性,所有患者均行药物或手术治疗,比较不同治疗方法患者入院时、治疗后6个月Vs、Vm、PI。结果 100例缺血性脑血管病患者,轻度狭窄42例,中度狭窄3... 相似文献
88.
Chou TH Wang S Sakhatskyy PV Mboudjeka I Mboudoudjeck I Lawrence JM Huang S Coley S Yang B Li J Zhu Q Lu S 《Virology》2005,334(1):134-143
Inactivated severe acute respiratory syndrome-associated coronavirus (SARS-CoV) has been tested as a candidate vaccine against the re-emergence of SARS. In order to understand the efficacy and safety of this approach, it is important to know the antibody specificities generated with inactivated SARS-CoV. In the current study, a panel of twelve monoclonal antibodies (mAbs) was established by immunizing Balb/c mice with the inactivated BJ01 strain of SARS-CoV isolated from the lung tissue of a SARS-infected Chinese patient. These mAbs could recognize SARS-CoV-infected cells by immunofluorescence analysis (IFA). Seven of them were mapped to the specific segments of recombinant spike (S) protein: six on S1 subunit (aa 12-798) and one on S2 subunit (aa 797-1192). High neutralizing titers against SARS-CoV were detected with two mAbs (1A5 and 2C5) targeting at a subdomain of S protein (aa 310-535), consistent with the previous report that this segment of S protein contains the major neutralizing domain. Some of these S-specific mAbs were able to recognize cleaved products of S protein in SARS-CoV-infected Vero E6 cells. None of the remaining five mAbs could recognize either of the recombinant S, N, M, or E antigens by ELISA. This study demonstrated that the inactivated SARS-CoV was able to preserve the immunogenicity of S protein including its major neutralizing domain. The relative ease with which these mAbs were generated against SARS-CoV virions further supports that subunit vaccination with S constructs may also be able to protect animals and perhaps humans. It is somewhat unexpected that no N-specific mAbs were identified albeit anti-N IgG was easily identified in SARS-CoV-infected patients. The availability of this panel of mAbs also provided potentially useful agents with applications in therapy, diagnosis, and basic research of SARS-CoV. 相似文献
89.
Survey of the Distribution of a Newly Characterized Receptor for Advanced Glycation End Products in Tissues 总被引:33,自引:2,他引:33
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jerold Brett Ann Marie Schmidt Shi Du Yan Yu Shan Zou Elliott Weidman David Pinsky Roman Nowygrod Michael Neeper Craig Przysiecki Alan Shaw Antonio Migheli David Stern 《The American journal of pathology》1993,143(6):1699-1712
Advanced glycation end products (AGEs), the final products of nonenzymatic glycation and oxidation of proteins, are found in the plasma and accumulate in the tissues during aging and at an accelerated rate in diabetes. A novel integral membrane protein, termed receptor for AGE (RAGE), forms a central part of the cell surface binding site for AGEs. Using monospecific, polyclonal antibody raised to human recombinant and bovine RAGE, immunostaining of bovine tissues showed RAGE in the vasculature, endothelium, and smooth muscle cells and in mononuclear cells in the tissues. Consistent with these data, RAGE antigen and mRNA were identified in cultured bovine endothelium, vascular smooth muscle, and monocyte-derived macrophages. RAGE antigen was also visualized in bovine cardiac myocytes as well as in cultures of neonatal rat cardiac myocytes and in neural tissue where motor neurons, peripheral nerves, and a population of cortical neurons were positive. In situ hybridization confirmed the presence of RAGE mRNA in the tissues, and studies with rat PC12 pheochromocytes indicated that they provide a neuronal-related cell culture model for examining RAGE expression. Pathological studies of human atherosclerotic plaques showed infiltration of RAGE-expressing cells in the expanded intima. These results indicate that RAGE is present in multiple tissues and suggest the potential relevance of AGE-RAGE interactions for modulating properties of the vasculature as well as neural and cardiac function, prominent areas of involvement in diabetes and in the normal aging process. 相似文献
90.
颈椎间管壁骨质增生的观察及其意义 总被引:32,自引:3,他引:32
在甘肃地区出土的成人颈椎骨骼标本390套(2730块)上,观测了钩椎关节、椎间关节、横突孔和椎体后缘的骨质增生,出现率高达22.5%。增生骨唇占据椎间管、横突孔和椎管的情况分轻、中、重三度. 相似文献