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The past 2 decades have witnessed an exponential increase in the incidence of hepatocellular carcinoma (HCC) in the United States and, concurrently, the development of liver transplantation as an effective modality in its treatment. "Early" HCC has been defined, allowing patients with unresectable HCC to be granted priority for transplant over the past decade. This situation has produced a dramatic increase in the number of transplants for HCC. The challenge has been how to expand the indications of liver transplant for HCC with improved cancer-free survival and fewer transplant-related complications without adversely affecting non-HCC transplant candidates. 相似文献
994.
995.
Inoue K Suwa S Ohta H Itoh S Maruyama S Masuda N Sugita M Daida H 《Circulation journal》2011,75(12):2813-2820
BACKGROUND: The aim of the present study was to evaluate the diagnostic accuracy of high-sensitivity troponin T (hsTnT) in patients with suspected acute coronary syndrome (ACS) in comparison to heart fatty acid-binding protein (H-FABP), high-sensitivity C-reactive protein, myeloperoxidase (MPO), and pentraxin 3 (PTX3). METHODS AND REsults: Patients (n=432) with chest pain were recruited for the analysis. ACS was diagnosed in 298 patients (69%). The diagnostic accuracy of measurements obtained at presentation, as quantified by the area under the receiver operating curve (AUC), was highest for hsTnT (AUC=0.82; 95% confidence interval [CI]: 0.78-0.87) and H-FABP (AUC=0.83; 95%CI: 0.78-0.87). Sensitivity (87.9%) and negative likelihood (LH; 0.2) for hsTnT were the highest and lowest, respectively, but H-FABP had the highest specificity (78.5%) and positive LH (3.6). Among patients who presented within 2h after the onset of chest pain, MPO had the highest AUC (0.82; 95%CI: 0.69-0.94). Combined use of H-FABP and MPO measurements yielded a sensitivity of 69.2%, specificity of 84.2%, positive LH of 4.4, and negative LH of 0.4. CONCLUSIONS: The hsTnT assay offers excellent diagnostic performance to rule out ACS, but it is prone to false-positive results. H-FABP offers similar overall diagnostic performance, while the combination of H-FABP and MPO assays may improve the diagnosis of ACS, particularly in patients with recent onset of chest pain. 相似文献
996.
Ohba S Sekine J Tobita T Ikeda H Asahina I 《Cranio : the journal of craniomandibular practice》2011,29(3):232-236
Although most fistulae are not problematic, surgeons occasionally encounter recurrent and/or refractory fistulae in the field of oral and maxillofacial surgery. In this case report, the authors describe a case in which a patient experienced a recurrent and refractory fistula or perforation at his oral floor through the submandible, with heterotopic bone formation arising on both sides of the mylohyoid line. These heterotopic bones were connected to each other, forming a bone bridge at the center of the oral floor. A fistulectomy and wound closure with a tongue flap was successful. The perforation has not recurred after over four years of follow-up, and the bone bridge is still present. 相似文献
997.
Seigo Yamashita Michifumi Tokuda Seiichiro Matsuo Saagar Mahida Eri Okajima Hachisuka Hidenori Sato Hirotsugu Ikewaki Hirotsuna Oseto Masaaki Yokoyama Ryota Isogai Kenichi Tokutake Kenichi Yokoyama Ryohsuke Narui Mika Kato Shinichi Tanigawa Kenichi Sugimoto Michihiro Yoshimura Teiichi Yamane 《Journal of cardiovascular electrophysiology》2019,30(11):2310-2318
998.
Yuichi Tomiki Seigo Ono Shun Ishiyama Kiichi Sugimoto Yukihiro Yaginuma Makoto Takahashi Yutaka Kojima Michitoshi Goto Kazuhiro Sakamoto Shu Hirai 《Clinical journal of gastroenterology》2011,4(1):1-4
We report a case of sigmoid colon carcinoma that developed from a sessile-type cancer in a short period of time. An 83-year-old
man was found to have a round sessile polyp, about 2 cm in diameter, in the sigmoid colon. Because he had taken anticoagulants,
immediate endoscopic mucosal resection and biopsy were not performed. Forty-three days later, the apical surface of the sessile
polyp had become depressed and ulcerated, and we judged that an endoscopic resection was not indicated for this lesion. The
histologic diagnosis of the biopsy specimens was a well-differentiated adenocarcinoma. We recommended surgical treatment;
however, the patient was not in favor of surgical treatment and would not consent to surgery. Two more examinations were performed
and the tumor was found to have developed into an invasive cancer with ulcerated, nodular margins involving 3/4 of the colonic
lumen. At 271 days after the initial examination, the patient finally consented to surgery and a partial resection of the
sigmoid colon was performed. The tumor was classified as stage I (T2N0M0). The several examinations performed from presentation
within a short time span provide evidence of the morphologic changes that occur when a sessile-type cancer develops into an
ulcerating invasive cancer. We hypothesize that remarkable configuration changes and development take place when a tumor becomes
invasive in the muscularis propria from massive submucosal invasion. Our findings suggest that among the tumors discovered
as typical ulcerating invasive type colon cancers are those that developed from protuberant tumors in a short period of time. 相似文献
999.
Fukazawa K Nishida S Volsky A Tzakis AG Pretto EA 《Journal of hepato-biliary-pancreatic sciences》2011,18(2):216-225