Understanding community beliefs of Chinese-Australians about cancer: initial insights using an ethnographic approach

Ethnography was employed to investigate the hypothesis that the cultural meaning of cancer is one of the possible barriers to access of cancer services. The objectives were to identify indigenous terminologies, taxonomies and illness explanatory models of cancer in a community-based sample of 15 Chinese-Australians and a sample of 16 informants who had been recruited through two Sydney familial cancer clinics. Many of the informants included in their narrative terms that seemed to match Western biomedical explanations for cancer. The majority of informants also maintained traditional Chinese beliefs, despite high acculturation and beliefs in biomedical explanations about cancer. Explanations of illness including cancer, referred to the following concepts: (i) karma (yeh), (ii) retribution (bao ying), (iii) fate (ming yun) or Heaven's or God's will, (iv) geomancy (feng-shui), (v) touched evil (zhong chia), (vi) misfortune or bad luck (shui wan, dong hark); (vii) offending the gods or deities requiring prayers or offerings for appeasement; and (viii) kong-tau (spells invoked through human intervention). Taking into consideration the heterogeneity of the Chinese population, the findings provide an insight into Chinese illness conceptualization that may assist health professionals to develop an understanding of how the cultural explanatory models affect access to screening services, communication of diagnosis of cancer and management of treatment regimen.     

Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in rats

Rationale Sex differences have been reported in physiological and behavioral responses to cocaine, but it is unclear whether sex differences exist in conditioned-cued relapse to cocaine seeking after prolonged abstinence. Furthermore, the role of estrous cyclicity in conditioned-cued relapse has not been investigated.Objective We assessed the influence of sex and estrous cyclicity on conditioned-cued reinstatement of drug-seeking behavior in Sprague–Dawley rats.Methods Rats were trained to self-administer intravenous cocaine (unconditioned stimulus, US; 0.25, 0.4, 0.5, 0.6, or 1.0 mg/kg per infusion) paired with light+tone conditioned stimuli (CSs) and were subsequently tested for the ability of the CSs to reinstate extinguished cocaine seeking (i.e., nonreinforced lever responding).Results Females exhibited more responding on the cocaine-paired lever during self-administration and extinction than males. Subsequently, males exhibited equally robust conditioned-cued reinstatement of extinguished drug-seeking behavior independent of cocaine training dose. Males and females trained on 0.4–0.6 mg/kg cocaine reinstated to a similar extent. However, females trained on the lowest dose (0.25 mg/kg) exhibited less reinstatement than males, and the source of this effect was the absence of reinstatement in estrous females. In addition, independent of estrous state, females trained on the highest dose (1.0 mg/kg) exhibited less reinstatement than males.Conclusions While males and females are equally responsive to cocaine-paired CSs when the conditions for CS–US association are optimal, females appear to attribute less motivational significance to the CS when it presumably acquires weaker motivational salience because of (a) a low cocaine dose or (b) weaker CS–US contiguity due to the prolonged effects of a high cocaine dose.     

The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors

BACKGROUND: It has been reported previously that the combined loss of chromosomal arms 1p and 19q is a significant predictor of outcome for patients with anaplastic oligodendroglial (AO) tumors and that such chromosomal loss correlates with classic histology in AO. The authors sought to determine whether histology was an equivalent or superior predictor of outcome compared with 1p/19q status in 131 patients with AO tumors. METHODS: The status of 1p and 19q was determined using real-time, quantitative polymerase chain reaction analysis and/or fluorescence in situ hybridization. Clinical features (response to adjuvant therapy and tumor location) and molecular genetic abnormalities (9p and 10q deletions, overexpression of p53 and epidermal growth factor receptor) were determined on available specimens. Histologic assessments for classic oligodendroglial features were performed by five neuropathologists. RESULTS: Classic histology was associated closely with 1p/19q loss, as reported previously. Patients who had tumors that were considered classic by at least four of the five neuropathologists showed significantly increased progression-free and overall survival compared with the patients who had less classic tumors. The authors also tested the correlation between 1p/19q status and outcome in subsets of patients stratified according to classic tumor features. The association of 1p/19q status with survival was related closely to the presence of classic histology. Loss of 1p/19q was predictive of improved outcome only among patients who had tumors with classic histologic features. CONCLUSIONS: The current results suggested that, in addition to 1p/19q status, histologic features contribute information to the prediction of outcome in patients with AO. Loss of 1p and 19q appeared to be a prognostic marker only in the subset of patients who had AO tumors with classic histologic features.     

Laser arytenoidectomy for bilateral vocal fold palsy in Parkinson's disease

We report a case of laser arytenoidectomy for bilateral abductor palsy of the vocal fold in a patient with Parkinson's disease. Parkinson's disease is known to be a rare cause for bilateral vocal fold palsy and this is the second case reported in the English literature. Majority of the reports to date are in the non-English literature. Tracheostomy has been the classic treatment option offered to these patients. To date no report has been found in the literature about a laser arytenoidectomy being performed in a patient suffering from bilateral vocal fold palsy in Parkinson's disease. We have suggested this option as it improves the quality of life of the individual and avoids the difficulty faced by a Parkinson's patient in managing tracheostomy care due to bradykinesia, rigidity and tremor.     

Nitrogen nutrition and isotopic discrimination in tropical ectomycorrhizal fungi

It is known that many ectomycorrhizal (EcM) fungi are able to utilise complex organic sources of nitrogen. Two hypotheses were tested using isolates of tropical EcM fungi grown in vitro: (i) EcM fungi isolated from mineral soils of tropical rain forests are less able to utilise organic sources of nitrogen than mineral sources; and (ii) nitrogen isotope discrimination patterns follow those of the nitrogen source utilised. Pisolithus albus and Tomentella sp. represented tropical EcM fungi and they were grown along with Thelephora terrestris. All three species were able to utilise bovine serum albumen as a nitrogen source and P. albus produced the greatest biomass on this source of nitrogen. Nitrate was generally less well utilised than ammonium although all three species were able to grow on this nitrogen source. The nitrogen source which led to the greatest biomass also led to the highest fungal nitrogen concentration in P. albus and Tomentella sp., but not T. terrestris. All three species discriminated against (15)N when grown on BSA and NO(3) but there were interspecific differences in isotope discrimination when grown on NH(4). From a limited number of isolates, it was found that EcM fungi from tropical soils utilise protein nitrogen as well as mineral nitrogen and there can be considerable nitrogen isotope discrimination during the utilisation of all these nitrogen sources.     

Norms of performance of sustained attention among a community sample: Continuous Performance Test study

Abstract  The Continuous Performance Test (CPT) is a widely used measure of sustained attention, which is a preferred tool for assessing various mental functions. A well-established norm for CPT is essential when choosing a suitable threshold for classifying individuals as either case (CPT impairment) or non-case. The CPT performance of 900 adults who were randomly chosen from a community survey was measured to establish the norms for subgroups with different gender, age, and educational levels. The results revealed that age and educational level are significantly associated with the performance sensitivity (d') of CPT. Male subjects perform better than female subjects. Seventeen percent of the subjects scored higher on the masked CPT than on the unmasked CPT. Subjects who could not finish the masked CPT had the characteristics of older age and fewer years of education. When classifying a patient as case or non-case, his/her CPT performance should be considered relative to the norms for his/her gender, age, and educational levels.