全文获取类型
收费全文 | 2457篇 |
免费 | 142篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 108篇 |
妇产科学 | 110篇 |
基础医学 | 234篇 |
口腔科学 | 90篇 |
临床医学 | 232篇 |
内科学 | 519篇 |
皮肤病学 | 60篇 |
神经病学 | 206篇 |
特种医学 | 51篇 |
外科学 | 339篇 |
综合类 | 17篇 |
一般理论 | 3篇 |
预防医学 | 299篇 |
眼科学 | 58篇 |
药学 | 138篇 |
中国医学 | 3篇 |
肿瘤学 | 117篇 |
出版年
2023年 | 15篇 |
2022年 | 41篇 |
2021年 | 69篇 |
2020年 | 39篇 |
2019年 | 71篇 |
2018年 | 76篇 |
2017年 | 53篇 |
2016年 | 74篇 |
2015年 | 89篇 |
2014年 | 100篇 |
2013年 | 133篇 |
2012年 | 185篇 |
2011年 | 192篇 |
2010年 | 110篇 |
2009年 | 106篇 |
2008年 | 179篇 |
2007年 | 166篇 |
2006年 | 152篇 |
2005年 | 143篇 |
2004年 | 153篇 |
2003年 | 90篇 |
2002年 | 108篇 |
2001年 | 51篇 |
2000年 | 38篇 |
1999年 | 27篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1992年 | 9篇 |
1991年 | 15篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1983年 | 7篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 11篇 |
1969年 | 5篇 |
1968年 | 2篇 |
排序方式: 共有2616条查询结果,搜索用时 15 毫秒
51.
52.
Hegyi P Rakonczay-Jr Z Sari R Czako L Farkas N Gog C Nemeth J Lonovics J Takacs T 《World journal of gastroenterology : WJG》2004,10(15):2275-2277
AIM: In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8), the process of regeneration following L-arginine (Arg)-induced pancreatitis is accelerated. In rats that were also diabetic (induced by streptozotocin, STZ), pancreatic regeneration was not observed. The aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats.METHODS: Male Wistar rats were used for the experiments.Diabetes mellitus was induced by administering 60 mg/kg body mass of STZ intraperitoneally (i.p.), then, on d 8, pancreatitis was induced by 200 mg/100 g body mass Argi.p. twice at an interval of 1 h. The animals were injected subcutaneously twice daily (at 7 a.m. and 7 p.m.) with 1 μglkg of CCK-8 and/or 2 IU mixed insulin (300 g/L shortaction and 700 g/L intermediate-action insulin) for 14 d after pancreatitis induction. Following this the animals were killed and the serum amylase, glucose and insulin levels as well as the plasma glucagon levels, the pancreatic mass/body mass ratio (pm/bm), the pancreatic contents of DNA, protein, amylase, lipase and trypsinogen were measured. Pancreatic tissue samples were examined by light microscopy on paraffin-embedded sections.RESULTS: In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein, amylase and lipase vs the rats receiving only CCK-8 treatment. CCK-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities, whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats.CONCLUSION: Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats,the simultaneous administration of exogenous insulin restored this effect. Our results clearly demonstrate that insulin is necessary for the hypertrophic effect of low-doses of CCK-8 following acute pancreatitis. 相似文献
53.
54.
Fatma E. Akin Cenk Sari Sevil ?zer-Sari Aylin Demirezer-Bolat Tahir Durmaz Telat Keles Osman Ersoy Engin Bozkurt 《Saudi Journal Of Gastroenterology》2016,22(2):116-121
Background/Aim:
The aim of this study was to investigate the effects of celiac disease on cardiac functions using tissue Doppler echocardiography (TDE).Patients and Methods:
The study included 30 patients with celiac disease (CD) and 30 healthy volunteers. Echocardiographic examinations were assessed by conventional echocardiography and tissue Doppler imaging. The peak systolic velocity (S''m), early diastolic myocardial peak velocity (E''m), late diastolic myocardial peak velocity (A''m), E''m/A''m ratio, myocardial precontraction time (PCT''m), myocardial contraction time (CT''m), and myocardial isovolumetric relaxation time (IVRT''m), E to E''m ratio were measured.Results:
In pulsed wave Doppler echocardiography, mitral late diastolic flow (A) velocity and E to E''m ratio were significantly higher (P = 0.02 and P = 0,017), E/A ratio was significantly lower (P = 0.008) and IVRT was significantly prolonged (P = 0.014) in patients with CD. In TDE, S''m, E''m, and E''m/A''m ratio were significantly lower, IVRT''m was longer (P = 0.009) from septal mitral annulus and S''m, E''m, E''m/A''m ratio were significantly lower, PCT''m, PCT/ET ratio, IVRT''m were longer, and MPI was higher from lateral mitral annulus in celiac group than controls.Conclusion:
Our study confirms that patients with CD have impaired diastolic function. More importantly, we also demonstrated an impairment of myocardial systolic function in patients with CD by TDE. We recommend using TDE in addition to conventional echocardiography parameters for the cardiovascular risk assessment of patients with CD. 相似文献55.
Stenholm S Rantanen T Heliövaara M Koskinen S 《Journal of the American Geriatrics Society》2008,56(3):462-469
OBJECTIVES: To study the association between different obesity indicators and walking limitation and to examine the role of C‐reactive protein (CRP) and handgrip strength in that association. DESIGN: A cross‐sectional, population‐based study. SETTING: The Health 2000 Survey with a representative sample of the Finnish population. PARTICIPANTS: Subjects aged 55 and older with complete data on body composition, CRP, handgrip strength, and walking limitation (N=2,208). MEASUREMENTS: Body composition, anthropometrics, CRP, medical conditions, handgrip strength, and maximal walking speed were measured in the health examination. Walking limitation was defined as maximal walking speed less than 1.2 m/s or difficulty walking half a kilometer. RESULTS: The two highest quartiles of body fat percentage and CRP and the two lowest quartiles of handgrip strength were all significantly associated with greater risk of walking limitation when chronic diseases and other covariates were taken into account. In addition, high CRP and low handgrip strength partially explained the association between high body fat percentage and walking limitation, but the risk of walking limitation remained significantly greater in persons in the two highest quartiles than in those in the lowest quartile of body fat percentage (odds ratio (OR)=1.75, 95% confidence interval (CI)=1.19–2.57 and OR=2.80, 95% CI 1.89–4.16). The prevalence of walking limitation was much higher in persons who simultaneously had high body fat percentage and low handgrip strength (61%) than in those with a combination of low body fat percentage and high handgrip strength (7%). Using body mass index and waist circumference as indicators of obesity yielded similar results as body fat percentage. CONCLUSION: Low‐grade inflammation and muscle strength may partially mediate the association between obesity and walking limitation. Longitudinal studies and intervention trials are needed to verify this pathway. 相似文献
56.
Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment 总被引:1,自引:0,他引:1
Sari I Birlik M Gonen C Akar S Gurel D Onen F Akkoc N 《World journal of gastroenterology : WJG》2008,14(18):2912-2914
Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. 相似文献
57.
58.
Relation of Complementary‐Alternative Medicine use with glomerular filtration rate and depression in patients with chronic kidney disease at predialysis stage
下载免费PDF全文
![点击此处可从《Nephrology (Carlton, Vic.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
59.
60.
Tevfik Solakoglu Huseyin Koseoglu Roni Atalay Sevil O. Sari Oyku T. Yurekli Ebru Akin Aylin D. Bolat Semnur Buyukasik Osman Ersoy 《Saudi Journal Of Gastroenterology》2014,20(2):113-119