全文获取类型
收费全文 | 1527篇 |
免费 | 146篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 108篇 |
妇产科学 | 20篇 |
基础医学 | 230篇 |
口腔科学 | 35篇 |
临床医学 | 143篇 |
内科学 | 312篇 |
皮肤病学 | 46篇 |
神经病学 | 95篇 |
特种医学 | 18篇 |
外科学 | 234篇 |
综合类 | 31篇 |
一般理论 | 1篇 |
预防医学 | 78篇 |
眼科学 | 33篇 |
药学 | 182篇 |
中国医学 | 10篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 25篇 |
2022年 | 29篇 |
2021年 | 65篇 |
2020年 | 33篇 |
2019年 | 42篇 |
2018年 | 58篇 |
2017年 | 48篇 |
2016年 | 52篇 |
2015年 | 63篇 |
2014年 | 74篇 |
2013年 | 80篇 |
2012年 | 145篇 |
2011年 | 147篇 |
2010年 | 77篇 |
2009年 | 61篇 |
2008年 | 85篇 |
2007年 | 86篇 |
2006年 | 91篇 |
2005年 | 66篇 |
2004年 | 65篇 |
2003年 | 49篇 |
2002年 | 45篇 |
2001年 | 15篇 |
2000年 | 20篇 |
1999年 | 18篇 |
1998年 | 7篇 |
1997年 | 10篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 14篇 |
1992年 | 13篇 |
1991年 | 15篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1984年 | 4篇 |
1978年 | 3篇 |
1974年 | 3篇 |
1971年 | 3篇 |
1968年 | 2篇 |
1967年 | 3篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1957年 | 2篇 |
1925年 | 1篇 |
1919年 | 2篇 |
1918年 | 1篇 |
1916年 | 1篇 |
排序方式: 共有1676条查询结果,搜索用时 15 毫秒
81.
Decreases in blood pressure after the spinal injection of opioids suggest that intrathecal (IT) opioids may have a sympatholytic effect similar to that of local anesthetic drugs. We compared two groups of patients aged 10-16 yr (n = 10 in each group). Group One (IT group) received IT opioids. Group Two (Epidural group) received 0.5% bupivacaine epidurally. The sympathetic effects of IT opioids and epidural bupivacaine were monitored by the changes in toe relative to calf temperature and by the changes in pulse wave gradients with digital plethysmography. Changes in temperature gradients comparing calf to toe and increases in pulse amplitude indicate vasodilatation caused by sympathetic blockade in this model. Calf to toe temperature gradients (Deltacalf-Deltatoe) were evaluated by subtracting the two measurements. Pulse wave plethysmography was recorded before and after spinal and epidural injection at intervals of 10 min for 40 min. All patients demonstrated changes in their calf to toe gradients after IT and epidural injections (-3.2 +/- 1.6). Systolic blood pressure decreased from a mean of 70 +/- 15 mm Hg to 55 +/- 10 mm Hg. Pulse wave plethysmography amplitude increased after the intrathecal opioid and epidural bupivacaine injection similarly. We conclude that the increases in pulse wave amplitude and decreases in calf-toe gradients indicate a sympatholytic effect after IT opioids similar to that of local anesthetics. IMPLICATIONS: The sympatholytic effects of neuraxial opioids were compared with those of local anesthetics. Two groups of patients were assigned to receive a neuraxial opioid or bupivacaine. Our results demonstrate that opioids cause hypotension and peripheral vasodilatation similar to bupivacaine. This finding suggests that neuraxial opioids have a sympatholytic effect comparable to that of local anesthetic drugs. 相似文献
82.
Two patients with prolapse of an intususceptum through a perforation in the intussuscipiens are described. There was little peritonitis at exploration. Prolapse of an intussusceptum is an occasional operative finding in patients with perforated intussusception. 相似文献
83.
R. Saoji R. Samujh K. L. N. Rao K. L. Narasimhan S. K. Mitra 《Pediatric surgery international》1993,8(4):316-317
Thirteen cases of psoas abscess were treated by surgical drainage through Petit's triangle. This underutilized anatomic space provides a simple and effective route for drainage of retroperitoneal abscesses.
Correspondence to: K. L. N. Rao 相似文献
84.
85.
Sanchez EQ Martin AP Ikegami T Uemura T Narasimhan G Goldstein RM Levy MF Chinnakotla S Dawson S Randall HB Saracino G Klintmalm GB Klintmaim GB 《Transplantation proceedings》2005,37(10):4416-4423
METHODS: We reviewed our prospectively maintained database of 2005 liver transplantations. Therapy was either started de novo or converted from calcineurin inhibitors (CNIs) to sirolimus as the main immunosuppressive agent for nephrotoxicity or rejection. Glomerular filtration rate (GFR) was determined with iodine 125-labeled sodium isthalamate (Glofil-125), and serum creatinine concentration was obtained before and 3 months after transplantation, and yearly in both groups. Sirolimus levels were 10 to 15 ng/mL in patients at less than 3 months after transplantations and 5 to 10 ng/mL in the remaining patients. All patients received mycophenolate mofetil as maintenance therapy. RESULTS: Data for 29 patients in the de novo group and 35 in the conversion group were reviewed. Patients in the de novo group demonstrated an acute cellular rejection rate of 17.2%, 40% of which were steroid resistant. In this group, 48.2% discontinuation of sirolimus was necessary because of adverse effects. Patients in the conversion group demonstrated an acute cellular rejection rate of 2.8% and a 34.3% rate of sirolimus discontinuation. Seventeen (56.7%) patients at 1 year and 8 (44.4%) patients at 2 years demonstrated continued improvement in GFR. In the conversion group, case-control analysis did not demonstrate a significant difference in GFR and serum creatinine concentration (P > .05) at 1 and 2 years after conversion. At the time of review, no patients in the conversion group required hemodialysis. CONCLUSIONS: Conversion to sirolimus therapy is an effective strategy in improving renal function in patients with CNI-induced nephrotoxicity and can be done without increased rejection. Most of our patients (65.7%) tolerated sirolimus conversion. Of these, 56.7% and 44.4% demonstrated continued increase in GFR with the CNI-free regimen at 1 and 2 years, respectively. Long-term, large-population, prospective, randomized, controlled studies should further validate these results. 相似文献
86.
Arankalle VA Prabhakar SS Madhukar WA Hanumaih Dattatraya PS Chandra MA 《Emerging infectious diseases》2005,11(1):123-126
An encephalitis outbreak in 2003 in children from India was attributed to Chandipura virus. Sequence analyses of G, N, and P genes showed 95.6%-97.6% nucleotide identity with the 1965 isolate (G gene, 7-11 amino acid changes); N and P genes were highly conserved. 相似文献
87.
88.
89.
90.