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991.
This study examined HIV and hepatitis risk behaviours among anabolic-androgenic steroid (AAS) users and controls, providing a detailed assessment of both injection and sexual practices. Fifty AAS-using and 40 non-AAS-using weight trainers completed a semi-structured interview followed by a detailed questionnaire. The 'high risk' behaviour of sharing needles and syringes was not current practice among the AAS-using sample, with only one user reporting sharing injecting equipment in the past. However, for some users it was common practice to share multi-dose vials (19%) and to divide drugs using syringes (17%). Both these practices are potential routes for HIV and hepatitis infection. Significantly more AAS users (36%) reported increases in sex drive over the last three months than did the control subjects (5%). More AAS users than controls were engaging in sex with more than one partner while infrequently using condoms. These findings support the maintenance of needle exchange schemes which are essential to continued safe injecting practices among AAS users. The elevated sexual risk behaviour of AAS users could be due to AAS's effect of increasing sex drive or to a 'risk taking' personality trait among AAS users. 相似文献
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Camila Alexandrina Figueiredo PhD Maurício Lima Barreto Neuza Maria Alcantara-Neves Laura Cunha Rodrigues Philip John Cooper Alvaro A. Cruz Lain Carlos Pontes-de-Carvalho Denise C. Lemaire Ryan dos Santos Costa Leila D. Amorim Candelaria Vergara Nicholas Rafaels Li Gao Cassandra FosterMonica Campbell BS Rasika A. Mathias Kathleen C. Barnes 《The Journal of allergy and clinical immunology》2013
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Ram Kannan Sean Hartnett Rodger B. Voelker J. Andrew Berglund Jonathan P. Staley Peter Baumann 《Genes & development》2013,27(6):627-638
The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3′ end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage reaction during telomerase RNA maturation. The mechanism underlying spliceosome-mediated 3′ end processing has remained unclear. We now demonstrate that a strong branch site (BS), a long distance to the 3′ splice site (3′ SS), and a weak polypyrimidine (Py) tract act synergistically to attenuate the transition from the first to the second step of splicing. The observation that a strong BS antagonizes the second step of splicing in the context of TER1 suggests that the BS–U2 snRNA interaction is disrupted after the first step and thus much earlier than previously thought. The slow transition from first to second step triggers the Prp22 DExD/H-box helicase-dependent rejection of the cleaved products and Prp43-dependent “discard” of the splicing intermediates. Our findings explain how the spliceosome can function in 3′ end processing and provide new insights into the mechanism of splicing. 相似文献
998.
MB Delatycki M Wolthuizen MA Aitken C Hickerton SA Metcalfe KJ Allen 《Clinical genetics》2013,84(3):286-289
Hereditary hemochromatosis (HH) is a common preventable disorder of iron overload that can result in liver cirrhosis and reduced lifespan. Most HH is due to homozygosity for the HFE p.C282Y substitution. We conducted a study of screening for p.C282Y in high schools where p.C282Y heterozygotes (CY) individuals were informed of their genotype by letter. We studied whether these individuals understood the implications of their genotype, whether this resulted in anxiety or reduced health perception and whether cascade testing was higher in families of CY than wild‐type homozygous (CC) individuals. We found 586 of 5757 (1 in 10) screened individuals were CY. One month after receiving their result, 83% correctly answered that they have one copy of p.C282Y. There was no adverse change in anxiety or health perception from prior to screening to 1 month after receiving results. Significantly more family members of CY individuals than CC individuals were informed about HH and had testing for HH. In conclusion, we found that informing CY individuals of their genotype does not increase anxiety and the implications are generally well understood. This leads to cascade testing in a minority of families. CY individuals should be informed of their genetic status when identified by population screening. 相似文献
999.
Connie Marras MD PhD Kelly A. Mills MD Shirley Eberly MS David Oakes PhD Kelvin L. Chou MD PhD Matthew Halverson BA BS Sotirios A. Parashos MD PhD Christopher G. Tarolli MD MHPE Jin-Shei Lai PhD Cindy J. Nowinsky MD PhD Oksana Suchowersky MD Eric S. Farbman MD Lisa M. Shulman MD Tanya Simuni MD 《Movement disorders》2021,36(8):1979-1983
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Whitley W. Aamodt MD MPH Teresa Waligorska MSc Junchao Shen BS Thomas F. Tropea DO MPH MSTR Andrew Siderowf MD MSCE Daniel Weintraub MD Murray Grossman MD David Irwin MD MSTR David A. Wolk MD Sharon X. Xie PhD John Q. Trojanowski MD PhD Leslie M. Shaw PhD Alice S. Chen-Plotkin MD 《Movement disorders》2021,36(12):2945-2950