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991.
992.
993.
Nobuhiro Yoshijima Ryo Yanagisawa Hiromu Hase Makoto Tanaka Hikaru Tsuruta Hideyuki Shimizu Keiichi Fukuda Toru Naganuma Kazuki Mizutani Motoharu Araki Norio Tada Futoshi Yamanaka Shinichi Shirai Minoru Tabata Hiroshi Ueno Kensuke Takagi Akihiro Higashimori Yusuke Watanabe Masanori Yamamoto Kentaro Hayashida 《Catheterization and cardiovascular interventions》2020,95(1):35-44
994.
Kosuke Minaga Mamoru Takenaka Kentaro Yamao Ken Kamata Shunsuke Omoto Atsushi Nakai Tomohiro Yamazaki Ayana Okamoto Rei Ishikawa Tomoe Yoshikawa Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo 《World journal of gastroenterology : WJG》2020,26(9):947-959
BACKGROUND Although several techniques for endoscopic ultrasound-guided biliary drainage(EUS-BD)are available at present,an optimal treatment algorithm of EUS-BD has not yet been established.AIM To evaluate the clinical utility of treatment method conversion during single endoscopic sessions for difficult cases in initially planned EUS-BD.METHODS This was a single-center retrospective analysis using a prospectively accumulated database.Patients with biliary obstruction undergoing EUS-BD between May 2008 and April 2016 were included.The primary outcome was to evaluate the improvement in EUS-BD success rates by converting the treatment methods during a single endoscopic session.Secondary outcomes were clarification of the factors leading to the conversion from the initial EUS-BD and the assessment of efficacy and safety of the conversion as judged by technical success,clinical success,and adverse events(AEs).RESULTS A total of 208 patients underwent EUS-BD during the study period.For 18.8%(39/208)of the patients,the treatment methods were converted to another EUSBD technique from the initial plan.Biliary obstruction was caused by pancreatobiliary malignancies,other malignant lesions,biliary stones,and other benign lesions in 22,11,4,and 2 patients,respectively.The reasons for the difficulty with the initial EUS-BD were classified into the following 3 procedures:Target puncture(n=13),guidewire manipulation(n=18),and puncture tract dilation(n=8).Technical success was achieved in 97.4%(38/39)of the cases and clinical success was achieved in 89.5%of patients(34/38).AEs occurred in 10.3%of patients,including bile leakage(n=2),bleeding(n=1),and cholecystitis(n=1).The puncture target and drainage technique were altered in subsequent EUSBD procedures in 25 and 14 patients,respectively.The final technical success rate with 95%CI for all 208 cases was 97.1%(95%CI:93.8%-98.9%),while that of the initially planned EUS-BD was 78.8%(95%CI:72.6%-84.2%).CONCLUSION Among multi-step procedures in EUS-BD,guidewire manipulation appeared to be the most technically challenging.When initially planned EUS-BD is technically difficult,treatment method conversion in a single endoscopic session may result in successful EUS-BD without leading to severe AEs. 相似文献
995.
Kousaku Kawashima Nobuhiko Fukuba Yusuke Uemura Kuniko Ota Hideaki Kazumori Hiroki Sonoyama Akihiko Oka Yasumasa Tada Yoshiyuki Mishima Naoki Oshima Takafumi Yuki Tomoko Katsube Yoshikazu Kinoshita Shunji Ishihara 《Medicine》2020,99(47)
High rates of co-existing irritable bowel syndrome (IBS) and headache have been reported in western countries. We investigated that comorbidity in individuals in Japan, along with anxiety and depression in subjects with and without IBS symptoms and/or headache.This cross-sectional study was performed from April 2012 to January 2013 at the Matsue Seikyo General Hospital Health Check Center. Questionnaires concerning symptoms related to IBS (Rome III) and headache, as well as anxiety/depression score were sent to individuals scheduled to undergo an annual health check-up, then returned during the visit and analyzed in a blinded manner.A total of 2885 individuals returned completed questionnaires and were enrolled, of whom 218 (7.6%) met the IBS criteria. The rates of co-existing headache in subjects with and without IBS symptoms were 44.0% (96/218) and 22.9% (611/2667), respectively, indicating a significantly higher rate of co-existing headache in subjects with as compared to without IBS (odds ratio [OR] 2.65, P < .001). Furthermore, the percentage of subjects with anxiety along with comorbid IBS symptoms and headache was significantly greater as compared to those with IBS (OR 3.01, P = .001) or headache (OR 2.41, P < .001) alone. Unlike anxiety, the percentage of subjects with depression was not significantly different among the IBS/non-headache, non-IBS/headache, and IBS/headache groups.Subjects with IBS symptoms had a higher rate of co-existing headache as compared to those without IBS. Furthermore, those with comorbid IBS symptoms and headache had a greater association with anxiety than with depression, as compared to those with only IBS or headache. 相似文献
996.
997.
Tomonori Aoki Atsuo Yamada Kazuharu Aoyama Hiroaki Saito Gota Fujisawa Nariaki Odawara Ryo Kondo Akiyoshi Tsuboi Rei Ishibashi Ayako Nakada Ryota Niikura Mitsuhiro Fujishiro Shiro Oka Soichiro Ishihara Tomoki Matsuda Masato Nakahori Shinji Tanaka Kazuhiko Koike Tomohiro Tada 《Digestive endoscopy》2020,32(4):585-591
998.
Hidetsugu Saito Shinichiro Tada Hirotoshi Ebinuma Satoshi Tsunematsu Tatehiro Kagawa Naoki Kumagai Yasutaka Inagaki Tetsu Watanabe Kanji Tsuchimoto Toshio Morizane Hiromasa Ishii Masaharu Tsuchiya 《Journal of gastroenterology》1994,29(6):733-739
We have previously reported the effect of a differentiation inducer, sodium butyrate (SB), on human hepatocellular carcinoma
(HCC) cell lines, demonstrating that it was a potent inducer of differentiation. In the present study, we investigated the
alteration in expression of an antigen defined by a murine monoclonal antibody, H2, as well as alterations in the expression
of other antigens, on the HCC cell lines HCC-T, HCC-M, and PLC/PRF/5, since it is known that specific antigenic changes occur
during the differentiation of leukemic cells. The expression of the antigen defined by H2 increased immunocytochemically on
HCC-T, HCC-M, and PLC/PRF/5 during treatment with SB. A flowcytometric study showed that almost all the HCC-T and HCC-M cells
treated with SB highly expressed this antigen after 5 days' treatment. The antigen expression detected by H2 decreased after
the removal of SB from the medium. On the other hand, antigen expression detected by another monoclonal antibody, 5C11, was
not changed by this treatment. The expression of intracellular adhesion molecule (ICAM)-1 in HCC-T increased slightly, but
that of β2-microglobulin and HLA-DR did not change. These results demonstrated that some antigen expression was changed by
SB treatment and that the antigen defined by H2 seemed to be highly expressed on human HCC cells in the differentiated state. 相似文献
999.
Rina Nanba Satoshi Kuroda Mitsuhiro Tada Tatsuya Ishikawa Kiyohiro Houkin Yoshinobu Iwasaki 《Child's nervous system》2006,22(3):258-262
Objects This study aims to clarify the genetic background of moyamoya disease by comparing clinical features between familial and sporadic cases to reveal the responsible genes for familial moyamoya disease.Methods This study included 155 Japanese patients with moyamoya disease, which included 24 familial cases (10 family pedigrees) and 131 sporadic cases. Clinical features were compared between the familial and sporadic cases.Results and conclusion A female preponderance was significantly more prominent in the familial than in the sporadic group (P=0.0421). Mean age at onset was significantly lower in familial than in sporadic cases (P=0.004). In eight parent–offspring pairs, mean age at onset was significantly lower in the second than in the first generation (P<0.0001). These results suggest that familial moyamoya disease is associated with genetic anticipation and female predominance and that a genetic analysis study focused on expanded triplet repeats may clarify the pathogenesis of the disease. 相似文献
1000.
Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor 总被引:31,自引:12,他引:19 下载免费PDF全文
T Takeshita Y Goto K Tada K Nagata H Asao K Sugamura 《The Journal of experimental medicine》1989,169(4):1323-1332
A mouse hybridoma cell line, TU27, producing an mAb was established. TU27 mAb reacted with various human and Gibbon ape T cell lines bearing the IL-2R p75 (IL-2Rp75), but not with cell lines expressing only Tac antigen, IL-2Rp55, and numbers of its binding sites on cell surfaces were similar to those of high-affinity IL-2R. Radioimmunoprecipitation with TU27 mAb defined a molecule with a molecular mass of 75 kD on the surface of IL-2Rp75 bearing cells. TU27 mAb completely blocked IL-2 binding to IL-2Rp75 and to the high-affinity IL-2R but not to IL-2Rp55 composing the low-affinity IL-2R. The IL-2-dependent growth of a human T cell line, ILT-Mat, was significantly inhibited by TU27 mAb only at low concentrations of IL-2, and combination of TU27 mAb and H-31 mAb specific for IL-2Rp55 completely inhibited the cell growth even at high concentrations of IL-2. These data strongly suggest that TU27 mAb is specific for the human IL-2Rp75. 相似文献