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31.

Objective

To investigate the anxiety among mothers whom their babies have failed test results in the first stage of Universal Neonatal Hearing Screening Program.

Patients and methods

A cross-sectional study was carried out on mothers whom their baby have positive test results in the first stage of Universal Neonatal Hearing Screening Program. Face to face interview was conducted to obtain data on sociodemographic profiles, knowledge about hearing loss and past medical history. Symptoms experienced by the mothers due to positive hearing test results and level of anxiety were measured by using the Malay translation Beck Anxiety Inventory questionnaire. These mothers were then given an appointment to come for the second screening six weeks after the first screening. The same questionnaire was given to them before the start of the second screening. SPSS version 11.5 was used for data entry and analysis. Wilcoxon signed Rank Test was used to compare the level of anxiety between the first and second screening.

Results

From a total of 78 mothers who were participated during the first screening, 50 of them have completed the study at the second screening (response rate = 64%). Fifty-two percent of them knew about the hearing screening before hand. Ninety-six percent of the mothers became alert about their child response towards sounds after they knew that their child had failed the first hearing screening. During the first screening, 74% of the mothers felt mild anxiety which was decreased to 68% before the mothers undergone the second screening. Moderate anxiety was felt by 10% of the mothers during both the first and second screening. There were 8% of the mothers having severe anxiety during the first screening but have reduced to half (4%) before the mothers undergone the second screening. The anxiety level was significantly less before the second screening with the median score of 5 (IQR: 13.0) compared to after the first screening (8, IQR = 14.25); p = 0.001.

Conclusions

There are considerable portion of the mothers of false-positive test result during Universal Neonatal Hearing Screening Program experienced unacceptable anxiety. This group of mothers needs to be identified and given a necessary help.  相似文献   
32.
The aim of this work was to evaluate the diagnostic performance of grey-scale, color Doppler, and dynamic ultrasound (US) for diagnosing carpal tunnel syndrome (CTS) using the medical diagnostic test called nerve conduction study (NCS) as the reference standard, and to correlate the increase in median nerve (MN) cross-sectional area (CSA) with severity of CTS. Fifty-one patients (95 wrists) with clinical symptoms of idiopathic CTS were recruited. The CSA and flattening ratio of the MN were measured at the distal radio-ulnar joint, pisiform, and hamate levels; bowing of the flexor retinaculum was determined at the hamate level. The hypervascularity of the MN was evaluated. The transverse sliding of the MN was observed dynamically and recorded as being either normal or restricted/absent. Another 15 healthy volunteers (30 wrists) were recruited as controls. Interoperator reliability was established for all criteria. CTS was confirmed in 75 wrists (75/95: 79 %; 14 minimal, 21 mild, 23 moderate, 17 severe). CSA at the pisiform level was found to be the most reliable and accurate grey-scale criterion to diagnose CTS (optimum threshold: 9.8 mm2). There was a good correlation between the severity of NCS and CSA (r?=?0.78, p?相似文献   
33.
Flaviviruses cause febrile illnesses in humans that may progress to encephalitis and death. Both viral and host factors determine the level of virus replication and outcome of infection. In mice, genetically determined resistance conferred by the flavivirus resistance locus (Flv) is responsible for the restricted flavivirus replication and prevention of disease development. Majority of flaviviruses express significant virulence, replicate to high titers and cause high mortality in susceptible mice, while congenic resistant mice endure the infection, show significantly reduced levels of virus replication and remain healthy. In contrast, infection with West Nile virus subtype Kunjin (KUNV) causes morbidity and fatal outcomes even in mice that are naturally resistant to flaviviruses. There are two possible mechanisms that could account for such an unforeseen virulence of KUNV in resistant mice: (a) an abrogation of Flv-controlled natural resistance leading to high virus replication, or (b) massive virus-induced immunopathology in the brain. To identify the cause(s) of fatality of KUNV infection, disease progression, virus replication and brain histopathology were studied in parallel in resistant and congenic susceptible mice. While KUNV replicated to high titers causing early fatalities in susceptible mice, it showed only reduced replication associated with the delayed morbidity in resistant mice indicating no abrogation of the Flv resistance. No evidence of excessive immune cell infiltration and tissue damage following KUNV infection were found. However, incomplete KUNV clearance not previously described was perceived as an important source of pathogenesis in resistant mice.  相似文献   
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