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141.
Atil Bisgin Ibrahim Boga Orcun Yalav Ozge Sonmezler Sevcan Tug Bozdogan 《The breast journal》2019,25(5):1029-1033
Certain genetic predisposition factors, such as BRCA1 and BRCA2 mutations play a pivotal role in familial breast cancer development in both males and females. Due to this, the importance and necessity of genetic screening to identify mutations affecting the population is paramount. Undergoing genetic screenings allows for a more knowledgeable risk assessment for the patients and their care providers. The aim of this study was to evaluate the prevalence of BRCA1/BRCA2 mutated genes in the Turkish population among unselected patients. To identify the molecular markers, we utilized a gene panel analysis consisting of BRCA1 and BRCA2 genes, with a next generation sequencing platform (MiSeq System, Illumina). Sequencing was performed using leukocyte DNA from breast cancer patients. In‐silico analysis for novel mutations was carried out using SIFT, PolyPhen2 and MutationTaster. BRCA1 and BRCA2 pathogenic variants were identified in 18 of 129 (14%) patients among the study population; of those 18 patients, seven (39%) were found in the BRCA1 gene and 11 (61%) in the BRCA2 gene. Ten of the eleven BRCA2 variants (90%) were novel mutations. Four of ten (40%) of the novel mutations were determined to be deleterious and six out of ten (60%) were identified as single nucleotide variations. Clinically significant mutations of the BRCA1/BRCA2 genes are related to an increased susceptibility for breast cancer. There is however, little known about BRCA mutations amongst the general population. Thus, it is important that patients are able to undergo genetic screenings and counseling. This also allows for greater care from health care providers and can only facilitate disease prevention which in turn can lead to a decreased cancer morbidity rate. 相似文献
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Floating-Harbor syndrome is a rare disorder which is clinically characterized by short stature, retarded speech development, delayed bone ages, triangular face, bulbous nose and thin lips. We described two cases with Floating-Harbor syndrome and briefly reviewed the relevant literature. 相似文献
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EAACI/ENDA Position Paper: Diagnosis and management of hypersensitivity reactions to non‐steroidal anti‐inflammatory drugs (NSAIDs) in children and adolescents 下载免费PDF全文
Mona Kidon Natalia Blanca‐Lopez Eva Gomes Ingrid Terreehorst Luciana Tanno Claude Ponvert Chiang Wen Chin Jean Christoph Caubet Ozge Soyer Francesca Mori Miguel Blanca Marina Atanaskovic‐Markovic 《Pediatric allergy and immunology》2018,29(5):469-480
Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used in the pediatric population as antipyretics/analgesics and anti‐inflammatory medications. Hypersensitivity (HS) reactions to NSAID in this age group, while similar to adults, have unique diagnostic and management issues. Although slowly accumulating, published data in this age group are still relatively rare and lacking a unifying consensus. This work is a summary of current knowledge and consensus recommendations utilizing both published data and expert opinion from the European Network of Drug Allergy (ENDA) and the Drug Hypersensitivity interest group in the European Academy of Allergy and Clinical Immunology (EAACI). This position paper summarizes diagnostic and management guidelines for children and adolescents with NSAIDs hypersensitivity. 相似文献
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Serdar Sahin Havva Sezer Ebru Cicek Yeliz Yagz Ozogul Murat Yildirim Tevhide Betul Icli Ozge Polat Korkmaz Emre Durcan Cem Sulu Kayra Somay Bahar Bekdemir Sermin Borekci Dilek Yazici Oguzhan Deyneli Onder Ergonul Fehmi Tabak Yalim Dikmen Hande Mefkure Ozkaya Mustafa Sait Gonen Taner Damci Hasan Ilkova Volkan Demirhan Yumuk 《Obesity facts》2021,14(5):481