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21.
角膜移植术后角膜在共焦显微镜下的形态学改变 总被引:3,自引:0,他引:3
目的:研究角膜移植术后角膜组织在共焦显微镜(Confocal microscopy)下的形态学改变。方法:应用Conoscan2.0共焦显微镜对板层角膜移植术后3~7d患者12例(12只眼),术后1a患者8例(8只眼),穿透性角膜移植术后3~7d患者10例(10只眼),术后1a患者11例(11只眼)进行扫描检查,记录各层角膜图像。结果:板层角膜移植术后3~7d,植片中基质细胞较小,可见裂隙状暗纹和细小神经,层间为大面积高反光区,有点状颗粒沉积,植床水肿,细胞成像不清。移植术后1a,植片中未见神经,层间反光明显减弱,但仍有点状高反光颗粒沉积,植床中出现粗大裂隙状暗纹,内皮细胞密度正常。穿透角膜移植术后3~7d,植片中基质细胞“激活”,可见神经和后基质层的粗大暗纹,内皮细胞密度正常,细胞间可镶嵌有高反光点。术后1a,植片中基质细胞仍较小,未见神经,后基质层仍有裂隙状暗纹,内皮细胞体积增大,密度减少,高反光点消失。结论:Confoscan 2.0共焦显微镜可活体检查角膜移植术后角膜组织结构和细胞的病理改变,这对评估手术效果和临床观察以及跟踪随访具有重大意义。 相似文献
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Kensei Minoda 《眼科学报》1996,(1)
Purpose: To disclose the structure of visual pigment gene for a protanopia with specific variation.Methods: Exon 5 fragments of the red andgreen visual pigment genes from the protanopia with specific varnation as well as controls were amplified by poly-merase chain reaction (PCR). The PCR products were put through heteroduplex-SSCP analysis and PCR-RFLP (restriction fragement length polymorphism) analysis to clarify the specific variation. The specific variation of the exon 5 DNA fragment from the protanopia was identified by sequencing.Results: A novel 5'green-3'red hybrid gene fragment without the normal red and green visual pigment gene was discovered in the protanopia. He should only have a single visual pigment gene, 5'green-3'red hybrid gene, on his X chromosome. The fusion point is between codon 285 and codon 296 in exon 5. Conclusion : Unequal intragenic recombination may occur in exon 5 as well as its upstream. A 5'green-3'red hybrid gene may present independently on the X chromosome without ac 相似文献
23.
眼内异物合并外伤性白内障是眼外伤常见的致盲原因之一,各地报告的致盲率为20%~48.9%。本文对88例眼内异物合并外伤性白内障患者采用联合手术治疗,收到较好疗效,术前视力0.05以下占85.2%,术后矫正视力0.05以下占27.3%,矫正视力0.06~1.5占73.7%,其中矫正视力0.6~1.5者占22.8%。根据异物的性质、在眼内部位和晶体损伤情况选择不同的手术方式一次联合手术摘出异物和白内障,术后采用中西药配合治疗。联合手术可提高疗效,减少术后并发症.减少手术次数,减轻病人的痛苦,缩短病程,减少医疗费用.眼科学报1993;9:216—218. 相似文献
24.
左旋多巴对弱视眼视诱发电位影响的研究 总被引:6,自引:0,他引:6
目的:探讨左旋多巴治疗弱视的效果。方法:正常眼和弱视眼服用单次剂量左旋多巴前后进行图形视诱发电位(pattem visual evoked poten-tial,PVEP)检测。结果:正常眼服药后中空间频率PVEP的N_1P_1振幅和高空间频率PVEP的P_1N_2振幅增大,弱视眼服药后低空间频率PVEP的N_1波潜伏期和中空间频率PVEP的P_1波潜伏期缩短。结论:左旋多巴可改善弱视眼的视功能,可作为弱视的一种新的治疗方法。眼科学报1997;13:182—185。 相似文献
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Purpose: To observe the inhibitory action of homoharringtonine liposome during the healing process of wounds in the filtering sitesMethods: posterior sclerectomies were performed in 14 rabbits. Postoperatively one eye of each rabbit received subconjunctival injections of HH liposome and fellow eye received saline injection in a randomized masked fashion.Results; Fourteen days after operation the IOP of experimental eyes reduced significantly (P < 0.01) as compared with the controlled eyes, and the number of remaining filtering blebs increased noticeably (P< 0.05). Pathohistological examination revealed that the number of fibroblasts per square micron in the filtering sites and the thickness of the scars in the center of the filtering sites of the experimental eyes were less than those of the controlled eyes. No serious ocular toxic and side effects were found.Conclusion : This experiment suggests that homoharringtonine liposome can markedly inhibit the scar formation of filtering sites after glaucoma fi 相似文献
29.
Purpose: To investigate whether liposome encapsulated total alkaloid of Harmaline (TAH) as a therapeutic agent is beneficial to prevention of posterior capsular opacifi-cation (PCO).Methods: Liposome-encapsulated TAH was prepared by modified freeze-thawing method. 0. 1ml of liposome-encapsulated TAH (0. 2mg/ml) was injected into the capsular bag during extracapsular lens extraction (ECLE) of each eye in total 10 rabbit eyes. Blank liposome or balance salt solution (BSS) was used as control. Slit-lamp examination and histopathological examination was used to evaluated capsule opacifica-tion. Intraocular pressure (IOP) , density and morphology of corneal endothelia cells, the amplitude and latency of b wave of ERG were measured.Results: The inflammatory response was mild both in TAH treated and the control group. PCO formation occurred in the control group 2 weeks postoperatively, but the posterior capsule was clear in TAH treated eyes. 4 weeks and 8 weeks after operation, PCO occurred both in TAH treated 相似文献
30.
Purpose: To investigate the compliance of the patients with ocular fundus diseases with recommendation for follow-up examination after laser treatment, and the underlying reasons for non-compliance.Methods: 53 patients with ocular fundus disease were asked to fill in a questionnaire which includes the socio-demographic characteristics, fear of the fundus disease, conception of the laser treatment and the motivation for staying healthy. Variables were compared for the compliers group and the non-compliers group by chi-square test. Result; Of the 53 subjects, 35 were classified as non-compliers and 18 were classified as compliers. There was no statistically significant difference between the two groups on all selected socio-demographic factors, conception of the laser treatment and the motivation for staying healthy. Significant difference was found between the two groups on two of those items concerning the fear of the diseases (P<0. 05). About half of the participants showed the lack of knowledge about 相似文献