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41.
G?khan Tun?bilek Serdar Nasir Omer Ozkan Aycan Kayik?io?lu Emin Mavili 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2004,38(2):94-99
Defects in the sacrococcygeal and ischial soft tissues can be treated with gluteus maximus and posterior thigh V-Y advancement flaps. However, late complications include recurrence and dehiscence of the suture line. Increasing the amount of the soft tissues over the bony prominences and multilayered closure may have an advantage for long-term durability. We modified the V-Y advancement technique by de-epithelialising the medial parts of the flap and burying them under the opposing edge of the wound or the flap. Sixteen patients with various defects of the sacrococcygeal and ischial soft tissues were operated on using this technique. All the flaps healed well with no partial or complete loss of the flap. Three patients developed complications. The main advantage of our technique is the use of healthy tissues to obliterate the dead spaces under the edges of the wound or the opposing flap. In this way, not only the defect in the skin but the defect in the subcutaneous tissue, with its iceberg tip at the surface, is treated effectively. To have an additional layer of tissue between the bone and the superficial tissues provides an extra cushion of soft tissue and avoids putting the suture line directly over the bony prominences. We used this modification safely for both unilateral and bilateral flaps. It could also be used successfully in other parts of the body. 相似文献
42.
43.
CASE REPORT: A 12-year-old boy who had a history of Kawasaki disease 9 years ago experienced a subarachnoid hemorrhage by ruptured right posterior cerebral artery aneurysm. On day 1 operation, as the aneurysm was very fragile and bled easily, two intraoperative ruptures, including a very premature rupture, were encountered. As a result, a left hemiparesis especially severe in the left hand was caused by the right anterior thalamic infarction due to the occlusion of a thalamo-perforating artery arising near the neck of the aneurysm. DISCUSSION: The histopathological examination of the intraoperative excised aneurysmal dome disclosed the thickening of the endothelial inner due to the endothelial hypertrophy and the invasion of inflammatory cells. This finding of the aneurysm was partially mimicking the finding of the coronary artery of the patients with Kawasaki disease. The combination of cerebral aneurysm and Kawasaki disease has never been reported until now, and the etiology of the aneurysm of this patient is unclear. 相似文献
44.
Background
The telomeric region of mouse chromosome 12 has previously shown frequent allelic loss in murine lymphoma. The Bcl11b gene has been identified and suggested as a candidate tumor suppressor gene within this region. In this study, we aimed to elucidate whether Bcl11b is mutated in lymphomas with allelic loss, and whether the mutations we detected conferred any effect on cell proliferation and apoptosis. 相似文献45.
46.
47.
Hung J. Kim Torrance Jackson Konrad Noben–Trauth 《Journal of the Association for Research in Otolaryngology》2003,4(1):83-90
Genetic studies on spontaneous mouse mutants with hearing defects have provided important insights into the function of genes
expressed in inner ear hair cells. Here we report on our genetic analyses of the deaf mutants varitint-waddler (Va) and jerker
(Espnje). A high-resolution genetic map localizes VaJ to a 0.14 ± 0.08 cM region between D3Mit85 and D3Mit259 on distal chromosome
3. By comparative mapping, the human ortholog resides at 1p22.3 between markers D1S3449 and D1S2252. To study the effect of
different genetic backgrounds on the hearing phenotype, Espnje and VaJ were crossed to various inbred strains. Auditory-evoked
brainstem response tests on F2 progeny demonstrate that expression, inheritance, and penetrance of the hearing phenotype are
solely controlled by the mutant allele. To test for a genetic interaction between Espnje and Cdh23v, auditory function was
analyzed in double heterozygotes; no significant increases of thresholds of sound pressure levels were observed. The results
establish the framework for cloning the Va gene and provide valuable insights into the genetics of deafness mutations in the
mouse. 相似文献
48.
Abstract Surgical treatment of proximal humeral fractures still remains a challenge. This is primarily due to the fact that sufficient
implant fixation in humeral head fractures is often not achieved due to substantial bone tissue loss with increasing age.
In the last few years the locking plates and locking nails have been introduced into clinical practice with varying results.
The biomechanical studies have focused on locking plate osteosynthesis as well. The following paper focuses on bone quality,
biomechanical studies and biology of proper osteosynthesis and reviews the most recent literature. 相似文献
49.
50.
Uta Kraus-Tiefenbacher Lelia Bauer Antonella Scheda Carola Schoeber Joerg Schaefer Volker Steil Frederik Wenz 《BMC cancer》2007,7(1):178