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111.
Akar S Comlekci A Birlik M Onen F Sari I Gurler O Bekis R Akkoc N 《Endocrine journal》2005,52(1):149-151
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare complication of hyperthyroidism and an uncommon form of hypokalemic periodic paralysis. Its differentiation of more common forms of periodic paralysis is important because aggressive treatment can place the patient at risk for rebound hyperkalemia. Treatment of the underlying thyroid dysfunction cures the muscle symptoms. Here we describe a 37-year-old Turkish male with THPP whose paralysis attack recurred soon after administration of radioactive iodine. 相似文献
112.
AIMS AND BACKGROUND: In Turkey, it is a common belief that most family members of patients with cancer would not want them to be informed of a diagnosis of cancer. Our aim was to evaluate the attitudes and opinions of people accompanying cancer patients, regarding cancer diagnosis disclosure. METHODS: In a cross-sectional study 270 caregivers accompanying cancer patients during outpatient chemotherapy sessions were asked to fill in a questionnaire to determine their opinions regarding whether the diagnosis of cancer should be disclosed to the patients and their relatives or not. Timing of telling the diagnosis and from whom it should be learned were queried as well. Possible influential factors for the answers were analyzed with the chi-square test. RESULTS: Of the 270 accompanying persons, 130 (48.2%) said that the patients should be informed of the diagnosis, whereas a greater number (236, 87.4%) believed that the patient's relatives should be informed. Being younger than 40 years old (P = 0.0005), being unmarried (P = 0.002), having a higher educational status (P = 0.0001) and having passed less than four months since the diagnosis (P = 0.005) positively affected opinions regarding telling the truth to the patient. Higher education (P = 0.012) and high monthly income (P = 0.002) positively affected opinions regarding disclosing a diagnosis of cancer to the patient's relatives. CONCLUSION: As a result, in a survey of caregivers' points of view, more than half of the accompanying persons did not agree with disclosing a cancer diagnosis to patients, whereas the majority agreed with disclosing it to the relatives, and educational level seemed to be the major influential factor. 相似文献
113.
Nurullah Yüceer Dr. Mehmet Bahadn Güven M.D. Hasan Yilmaz 《Neurosurgical review》1998,21(2-3):181-184
Multiple hydatid cysts of the brain are uncommon and may be either primary or secondary. We report a 12-year-old child with
multiple hydatid cysts of the brain occuring 1 year after surgical rupture of a primary large and infected cerebral hydatid
cyst. Surgical removal of hydatid cysts was successfully performed. Albendazole (10 mg/kg twice daily for 12 weeks) was administered
to the patient in the postoperative stage. 相似文献
114.
115.
The aim of this study was to develop a Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and assess its reliability, validity, and sensitivity to change. The Turkish version was obtained after a translation and back-translation process. Seventy-one patients with ankylosing spondylitis were assessed with it. To assess its validity, patients were also evaluated with the Turkish version of the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath Ankylosing Spondylitis Metrology Index (BASMI), the Bath Ankylosing Spondylitis Patient Global Score (BAS-G), and physicians assessments of disease activity. Over 24 h, the Turkish BASDAI did not show significant differences between the two assessments (P>0.05). Correlations were found between BASDAI and all of the evaluation parameters except BASMI (P<0.01). Both BASDAI and BASMI showed significant improvements after 8-week home exercise programmes. The results of this study show that the Turkish version of the BASDAI is reliable, valid, and sensitive to change. 相似文献
116.
Taylan A Sari I Kozaci DL Yildiz Y Bilge S Coker I Maltas S Gunay N Akkoc N 《Clinical rheumatology》2012,31(1):23-28
Atherosclerosis has been shown to be increased in chronic inflammatory diseases including ankylosing spondylitis (AS). Impaired
endothelial function, the first step in atherosclerosis, may be reflected by changes in various endothelial biomarkers of
hemostasis and the release of several cellular adhesion molecules or cytokines. In this study, we investigated changes in
the levels of various possible markers with regard to disease activity and treatment regimen with/without anti-TNF-α drugs.
Fifty-six AS patients (44 males) and 27 controls (19 males) with no known cardiovascular risk factors were included in the
study. Spinal mobility was assessed by the Bath Ankylosing Spondylitis Metrology Index, and patients were evaluated with the
Bath Ankylosing Spondylitis Functional Index and the Bath Ankylosing Spondylitis Disease Activity Index. Cytokines and various
endothelial biomarkers were measured in serum samples using commercially available ELISA kits. Age, sex, BMI, waist circumference,
fasting glucose, MAP, lipids are all similar between patients and controls. von Willebrand factor (vWF), soluble thrombomodulin
(sTM), and urotensin (UT-II) were found to be significantly higher in the sera of the patients compared to the controls. Treatment
with anti-TNF-α compared to conventional therapy and disease activity in AS patients seemed to have no effect on the blood
levels of UT-II, sTM, CD146, vWF, plasminogen activator inhibitor-1, tissue plasminogen activator, or the thrombin–antithrombin
complex. The increased UT-II, sTM, and vWF in AS patient sera regardless of treatment and disease activity suggest an increased
tendency for atherosclerosis. 相似文献
117.
Nurullah ?elik Peyami Cinaz Aysun Bideci ?zge Yüce Hamdi Cihan Emeksiz Esra D??er Orhun ?amurdan 《Journal of clinical research in pediatric endocrinology》2014,6(1):55-58
Cardio-facio-cutaneous (CFC) syndrome is a rare disorder characterized by craniofacial dysmorphia, ectodermal abnormalities, cardiac malformations, as well as growth and developmental delay. Although some endocrine abnormalities have been reported in this syndrome, very little is known about CFC syndrome-related endocrine disorders. A 7.5-year-old boy was admitted to our endocrinology clinic with the complaint of short stature. He had a height of 103 cm [-4 standard deviation (SD)], a weight of 16 kg (<3th percentile, -1.7 SD), a facial appearance typical for the CFC syndrome, optic nerve hypoplasia and pulmonary stenosis. Genetic investigation revealed a heterozygous mutation in exon 3 of the MEK1 gene, c.389A>G (p. Y130C). During his long-term follow-up, the patient developed a variety of endocrine disorders including precocious puberty, growth hormone deficiency and hyperprolactinemia. 相似文献
118.
?zge Yüce Esra D??er Nurullah ?elik Hamdi Cihan Emeksiz Erkut Baha Bulduk Mahmut Orhun ?amurdan Aysun Bideci Peyami Cinaz 《Journal of clinical research in pediatric endocrinology》2014,6(3):174-176
Arachnoid cysts (ACs), particularly suprasellar cysts, cause a wide spectrum of endocrine disorders. Herein, we report two patients diagnosed with an extensive AC in the middle cranial fossa while being investigated for etiologies of precocious puberty and short stature. One of them required surgery due to his pubertal disorders associated with compression effects of cyst. After surgery, his puberty progression was regressed within one year. On the other hand, surgery was not planned for the second patient considering of his cranial imaging findings and the extremely low incidence of growth hormone (GH) deficiency caused by middle fossa AC (MFAC). We started treatment with recombinant human GH and no complication was found during treatment follow-up. Endocrine disorders associated with MFACs are extremely rare. By presenting with these two cases, we aimed to remain our fellow physcians that ACs can be possibly cause of endocrine disorders. Clinicians should be careful evaluating endocrine disorders because real cause may not be cyst itself but masked by it. 相似文献
119.
Evren Suer Nurullah Hamidi Mehmet Ilker Gokce Omer Gulpinar Kadir Turkolmez Yasar Beduk Sumer Baltaci 《World journal of urology》2016,34(6):847-851
Purpose
Although the role of second transurethral resection of bladder tumor (TURB) is well established in high-risk non-muscle-invasive bladder cancer, to the best of our knowledge, there is no study regarding the role of a second transurethral resection (TUR) after a complete first TURB in multimodal therapy (MMT). The aim of this study was to evaluate the role of a second TUR on disease-specific survival (DSS) and overall survival (OS) rates in muscle-invasive bladder cancer (MIBC) patients who were treated with MMT.Methods
We assessed the data of 90 patients (stage T2-4, N0-1, M0 urothelial cancer) who were treated with MMT at our clinic between January 2000 and June 2014. Patients with incomplete initial TURB were excluded. A total of 43 patients had a second TUR before starting radiochemotherapy of MMT (group 1), and 47 patients (group 2) were treated with MMT without having a second TUR. The impact of second TUR on DSS and OS rates was the primary outcome measure of the study.Results
Mean (SD, range) age and mean follow-up of the patients were 65.1 (7.1, 52–81) years and 60.3 (38.3, 6–159) months, respectively. The two groups were similar with regard to sex, age, presence of hydronephrosis, lymph node involvement and stage. The 5-year DSS rate was better in group 1 compared to group 2 (68 vs. 41 %) (p = 0.046). The 5-year OS rates of the patients were 63.7 and 40.1 % in groups 1 and 2, respectively (p = 0.054). Multivariate analysis revealed that second TUR, lymph node involvement, presence of hydronephrosis and tumor stage were independent prognostic factors for DSS.Conclusions
Second TUR should be performed in patients with MIBC who are going to be treated with bladder-preserving MMT protocols.120.
Akkoc N 《Current rheumatology reports》2008,10(5):371-378
The high-range estimate of 1.3% by the National Arthritis Data Workgroup for the prevalence of the entire spectrum of spondyloarthropathies
(SpAs) suggests that SpAs may be more prevalent than rheumatoid arthritis (RA) in the United States. Recent surveys from many
European countries using the same sample population have also found SpA to be at least as common as RA in most of the studied
populations, including Finnish, Swedish, Lithuanian, French, Italian, and Turkish. Among Asian populations, China has the
highest prevalence of SpA, with reported estimates generally higher than that of RA. In Thailand and Vietnam, the two diseases
are probably equally common, whereas RA seems to be more prevalent than SpA in the rest of Asia, the Pacific Region, and Latin
America, as indicated by studies following the COPCORD (Community-Oriented Program for the Control of Rheumatic Diseases)
protocol. Both rheumatic disorders are rare in Africa, but SpA is less common than RA. 相似文献