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排序方式: 共有1381条查询结果,搜索用时 15 毫秒
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Hirotsugu Uemura Dingwei Ye Ravindran Kanesvaran Edmund Chiong Bannakij Lojanapiwat Yeong-Shiau Pu Sudhir Kumar Rawal Azad Hassan Abdul Razack Hao Zeng Byung Ha Chung Noor Ashani Md Yusoff Chikara Ohyama Choung Soo Kim Sunai Leewansangtong Yuh-Shyan Tsai Yanfang Liu Weiping Liu Maximiliano van Kooten Losio Marxengel Asinas-Tan 《BJU international》2020,125(4):541-552
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β-Thalassemia (β-thal) is a monogenic disease characterized by mutations on the HBB gene, affecting the production of globin that results in hypochromic and microcytic anemia. The aim of this study was to determine the prevalence of six common β-thal mutations, and their frequency and inheritance pattern in affected populations of North Waziristan Agency, Pakistan. In this study, 130 blood samples from 37 unrelated β-thalassemic families having a minimum of one transfusion-dependent child with β-thal major (β-TM), were retrieved either from the Thalassaemia Centre for Women and Children Hospital Bannu or their home towns situated in Noth Waziristan Agency. All samples were analyzed by the amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) using six allele-specific primers for the presence of the six β-thal mutations common in the Pakistani population. Of the six common mutations, our study demonstrated five HBB mutations comprising HBB: c.27_28insG, HBB: c.92+5G>C, HBB: c.126_129delCTTT, HBB: c.92+1G>T and HBB: c.17_18delCT from the families studied, while mutation HBB: c.47G>A [codon 15 (G>A)] was not detected in any of the studied families. Furthermore, the HBB: c.27_28insG and HBB: c.92+5G>C were noted to be the most common with frequencies of 42.85 and 31.42%, respectively. The findings of the present study may be useful in launching carrier screening and prenatal diagnosis (PND) programs by screening analyzed and other unanalyzed affected families for the possible presence of common mutations through the ARMS-PCR technique that will help to control the disease. 相似文献
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Differentiated thyroid cancer is characteristically associated with an innocuous clinical course, but a minority of cases may manifest surprisingly aggressive behaviour. Such aggressive DTC are directly responsible for the majority of thyroid cancer related deaths. Moreover, they contribute indirectly to increased DTC-related morbidity, because our inability to differentiate these tumours from innocuous DTC at an early stage fuels a significant degree of DTC overtreatment around the globe. In the present paper we describe how improved understanding of the clinicopathological thyroid tumour progression model and optimization of clinical staging systems continues to improve our ability to diagnose and treat aggressive DTC. Early recognition of aggressive DTC allows instillation of an aggressive management strategy which is based upon surgical-oncologic completeness, and minimization of treatment-related sequelae through continued development of reconstructive options and focussed delivery of adjuvant treatments. 相似文献
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目的:研究未经正畸治疗的前牙有牙根吸收和无牙根吸收的错[牙合]患者的[牙合]及功能[牙合]特征,揭示引起牙根吸收的可能的[牙合]及咬合因素,为正畸治疗治疗前已有牙根吸收的患者提供可能的[牙合]及功能[牙合]参照标准。方法:用曲面断层片作为筛查方法,并用根尖片进一步确诊根尖吸收,对07年7月至08年3月在我正畸科初诊的患者进行调查,从中选择14名前牙根尖吸收为Ⅱ~Ⅲ度的错[牙合]畸形患者作为研究组,用年龄和性别作为控制标准随机选择14名无根尖吸收的错[牙合]畸形患者作为对照组,采用临床检查、模型分析和DenarMarkⅡ[牙合]架分析的方法研究两组的[牙合]和功能[牙合]特征,用spss14.0进行t检验统计分析。结果:两组的[牙合]特征不存在差异,临床检查和[牙合]架分析的结果均显示前牙牙根吸收组在侧方运动中前牙和后牙出现[牙合]干扰的数量高于对照组,其中[牙合]架分析发现牙根吸收患者在侧方运动中前牙出现[牙合]干扰的数量显著高于对照组(P〈0.05)。结论:未经治疗的错[牙合]畸形患者在侧方运动过程中前牙[牙合]干扰是发生前牙牙根吸收者可能原因。 相似文献
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Dalton HR Stableforth W Thurairajah P Hazeldine S Remnarace R Usama W Farrington L Hamad N Sieberhagen C Ellis V Mitchell J Hussaini SH Banks M Ijaz S Bendall RP 《European journal of gastroenterology & hepatology》2008,20(8):784-790
AIMS: To report the natural history of autochthonous hepatitis E and hepatitis E virus (HEV) IgG seroprevalence in Southwest England. METHODS: Patients with unexplained hepatitis were tested for hepatitis E and cases followed until recovery or death. Five hundred blood donors, 336 individuals over the age of 60 years and 126 patients with chronic liver disease were tested for HEV IgG. RESULTS: Forty cases of autochthonous hepatitis E (genotype 3) were identified. Hepatitis E was anicteric in 25% of cases and usually caused a self-limiting hepatitis predominantly in elderly Caucasian males. Six of 40 had a significant complication and three patients died, two of who had previously undiagnosed cirrhosis. Hepatitis E shows a seasonal variation with peaks in the spring and summer and no cases in November and December. HEV IgG prevalence increases with age, is more common in men and is 16% in blood donors, 13% in patients with chronic liver disease and 25% in individuals over 60 years. CONCLUSION: Autochthonous hepatitis E is more common than previously recognized, and should be considered in the differential diagnosis in patients with hepatitis, whatever their age or travel history. It carries a significant morbidity and when seen in the context of chronic liver disease carries an adverse prognosis. 相似文献