全文获取类型
收费全文 | 18309篇 |
免费 | 1453篇 |
国内免费 | 573篇 |
专业分类
耳鼻咽喉 | 203篇 |
儿科学 | 516篇 |
妇产科学 | 236篇 |
基础医学 | 1961篇 |
口腔科学 | 351篇 |
临床医学 | 2234篇 |
内科学 | 3383篇 |
皮肤病学 | 317篇 |
神经病学 | 1024篇 |
特种医学 | 616篇 |
外国民族医学 | 3篇 |
外科学 | 1741篇 |
综合类 | 2087篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 1397篇 |
眼科学 | 526篇 |
药学 | 1634篇 |
20篇 | |
中国医学 | 751篇 |
肿瘤学 | 1332篇 |
出版年
2024年 | 47篇 |
2023年 | 210篇 |
2022年 | 503篇 |
2021年 | 794篇 |
2020年 | 578篇 |
2019年 | 527篇 |
2018年 | 718篇 |
2017年 | 581篇 |
2016年 | 515篇 |
2015年 | 767篇 |
2014年 | 898篇 |
2013年 | 962篇 |
2012年 | 1323篇 |
2011年 | 1423篇 |
2010年 | 873篇 |
2009年 | 636篇 |
2008年 | 966篇 |
2007年 | 1014篇 |
2006年 | 865篇 |
2005年 | 834篇 |
2004年 | 725篇 |
2003年 | 689篇 |
2002年 | 663篇 |
2001年 | 529篇 |
2000年 | 576篇 |
1999年 | 469篇 |
1998年 | 158篇 |
1997年 | 126篇 |
1996年 | 128篇 |
1995年 | 108篇 |
1994年 | 64篇 |
1993年 | 56篇 |
1992年 | 152篇 |
1991年 | 120篇 |
1990年 | 103篇 |
1989年 | 109篇 |
1988年 | 88篇 |
1987年 | 75篇 |
1986年 | 67篇 |
1985年 | 52篇 |
1984年 | 38篇 |
1983年 | 23篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 11篇 |
1979年 | 14篇 |
1977年 | 12篇 |
1973年 | 9篇 |
1970年 | 9篇 |
1965年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
外科护理文书存在的风险及管理对策 总被引:5,自引:4,他引:1
对外科护理文书的风险细节管理中存在的问题进行阐述,提出强化外科护士的法律意识,树立风险源于细节的管理意识,保证护理文书记录的科学性、及时性、准确性及真实性,注重护患沟通,提高护理质量是降低护理风险,避免医疗纠纷发生的关键。 相似文献
22.
Raúl González-García Francisco J Rodríguez-Campo Verónica Escorial-Hernández Mario F Mu?oz-Guerra Jesús Sastre-Pérez Luis Naval-Gías José L Gil-Díez Usandizaga 《Journal of oral and maxillofacial surgery》2006,64(11):1587-1591
PURPOSE: Temporomandibular joint (TMJ) arthroscopy has been considered a safe surgical procedure in the treatment of TMJ derangement. However, it is not exempt from complications. This study evaluates the complications of arthroscopy in patients with internal derangement of TMJ. PATIENTS AND METHODS: Five hundred consecutive patients (670 joints) with TMJ derangement who underwent arthroscopy between 1995 and 2004 were retrospectively analyzed. All the patients were classified as II to V in the Wilkes classification. Lysis and lavage, electrocautery of the posterior ligament, injection of corticoids, injection of ethanolamine, myotomy of lateral pterygoid muscle attachments, myotomy and electrocautery, motor debridement, injection of sodium hyaluronate, and meniscal suture were performed in different patients. RESULTS: Complications were recognized during or immediately after the surgery. They were observed in 5 of 341 (1.26%) arthroscopies of the right TMJ and 4 of 329 (1.21%) arthroscopies of the left TMJ. A 1.34% complication rate was found in the whole series. No blood clots within the external auditory canal were observed. Bleeding within the superior TMJ space was observed in 57 cases (8.5%), 36 of them in the right TMJ and 21 in the left TMJ, but they were not considered as true complications. Lacerations of the external auditory canal were found in 2 cases (0.3%), with no cases of perforation of the tympanic membrane. Lesion of the auriculotemporal nerve was observed in a case. Paresia of the facial nerve was found in 4 cases (0.6%). Alteration of visual accuracy of the ipsilateral eye was also observed in a patient immediately after the surgery. CONCLUSION: Special care must be taken to reduce complications within the upper joint space by means of an adequate instrumentation and by paying attention to essential points of the arthroscopic technique. 相似文献
23.
Carlos Ferrer Albiach Antonio Conde Moreno Marta Rodríguez Cordón Virginia Morillo Macías Ana Bouché Babiloni Inmaculada Beato Tortajada Ángel Sánchez Iglesias Alicia Francés Muñoz 《Clinical & translational oncology》2010,12(1):22-26
Hypoxia is related to poor prognosis because it is associated to chemo-and radioresistance. During recent years the evolution
of imaging methods like PET/CT and MRI has meant the appearance of new perspectives with direct implications in radiation
therapy. We discuss previous experiences in staging, planning and in the follow-up process with these techniques for measuring
tumour hypoxia. 相似文献
24.
25.
M D Blanco M V Bernardo R L Sastre R Olmo E Mu?iz J M Teijón 《European journal of pharmaceutics and biopharmaceutics》2003,55(2):229-236
Poly(epsilon-caprolactone) microspheres containing bupivacaine were prepared by the spray-drying process. The average size of drug loaded microspheres was less than 3 microm in diameter, and the percentage of entrapment efficiency was 91 +/- 3%. In vitro drug release kinetic in phosphate buffer at 37 degrees C showed a hyperbolic profile, with a burst-effect during the first hour. Subcutaneous injection of bupivacaine-loaded microspheres in the back of rats caused an increase in drug concentration in plasma. Maximum bupivacaine concentration in plasma was 237 +/- 58 ng/ml at 105 h, and drug was detected in plasma for 16 days. The half-life time of the drug was increased by more than 125 times with regard to that of the drug administered in a solution by intraperitoneal injection. After 30 days of injection, a mass formed by microspheres surrounded by a thin fibrous capsule was observed. Small blood vessels and multinucleate foreign body giant cells with macrophagic function around microspheres were detected. After 60 days of injection a subcutaneous mass was also observed, which was formed of more degraded dispersed microspheres in conjunctive tissue, which had a normal structure. Thus, bupivacaine-loaded poly(epsilon-caprolactone) microspheres could be considered as a device to be used in the treatment of severe pain that is not responsive to opioids for example in cancer-related syndromes or in intractable herpetic neuralgia. 相似文献
26.
27.
We propose a new self-organizing neural model that performs principal components analysis. It is also related to the adaptive subspace self-organizing map (ASSOM) network, but its training equations are simpler. Experimental results are reported, which show that the new model has better performance than the ASSOM network. 相似文献
28.
Xiangyu Piao Changkai Sun Zhe Jin Jing Yu Xiaodan Chang Xin Tang Hongmei Liu Peiyang Zhou 《中国神经再生研究》2007,2(9):540-543
BACKGROUND: The cerebral ischemia and ischemia/reperfusion animal models are used to simulate the human cerebrovascular diseases is one of the popular topics of neurological science recently. To study the pathophysiology, pathogenesis, prophylaxis and treatment of ischemic cerebrovascular diseases and to establish the ideal animal model that is the most similar to the human cerebral ischemia, are the topics that the people generally cared about.
OBJECTIVE: To evaluate the effects of aerocyst-blocking bilateral ascending pharyngeal artery on the establishment of cerebral ischemia models by using digital subtraction angiography (DSA), magnetic resonance diffusion-weighted imaging (DWI) and magnetic resonance perfusion-weighted imaging (PWI).
DESIGN: Repetitive measure animal experiment.
SETTING: Zhongshan Hospital Affiliated to Dalian University.
MATERIALS: The experiment was carried out in the Animal Laboratory (Provincial Laboratory), Zhongshan Hospital of Dalian Univeristy from January to May 2006. A total of 14 domestic piglets, of 6 months old, weighing 12–15 kg, of either gender, were selected from Animal Experimental Center, Dalian University. Multistar T.O.P digital subtraction angiography machine was provided by Siemens Company, German.
METHODS: Aerocyst-blocking bilateral ascending pharyngeal artery was used to establish cerebral ischemia models. And then, Multistar T.O.P. DSA was used for imaging of cerebral vessels before blocking, during blocking and at 0.5 and 2 hours after ischemia perfusion. GE Signa 1.5 T supraconduction magnetic resonance imaging was used for DWI examination; in addition, PWI was used based on focal sites and areas. Otherwise, magnetic resonance imaging (MRI) was used to detect signal changes of T1WI and T2WI in ischemic areas.
MAIN OUTCOME MEASURES: Analytic results of DSA, DWI, PWI and MRI.
RESULTS: All 14 experimental piglets were involved in the final analysis. ① DSA: The blood flow of bilateral ascending pharyngeal arteries and its branch were blocked at blocking phase, which restored 0.5 and 2 hours after reperfusion. ② DWI and PWI: There were no observable abnormalities in PWI and DWI at pre-blocking. Abnormal increased signals were found on both DWI and PWI at during and post-blocking. There were reduction in ADC and rCBF and delay in rTTP at all time points except pre-blocking. ③ MRI: There were no abnormal signals observable at any time of pre- and post-blocking in T1WI and T2WI.
CONCLUSION: It is feasible to establish this kind of animal experimental models, and it can simulate the ischemic state; meanwhile, the existence and extent can be showed directly by DSA, DWI, and PWI. 相似文献
29.
M. I. Manrique-Poyato A. J. Muñoz-Pajares V. Loreto M. D. López-León J. Cabrero J. P. M. Camacho 《Chromosome research》2006,14(6):693-700
We have analysed B chromosome frequency for three consecutive years, B transmission rate at population and individual levels,
clutch size, egg fertility and embryo–adult viability in a natural population of the grasshopper Eyprepocnemis plorans containing two different B chromosome variants, i.e. B2 and B24, the second being derived from the first and having replaced it in nearby populations. From 2002 to 2003 the relative frequency
of both variants changed, although the differences did not reach significance. A mother–offspring analysis showed no significant
effect of any of the two B variants on clutch size, egg fertility or embryo–adult viability, but B24 was more efficiently transmitted than B2 through males from the 2002 season, which explains the observed frequency change. Controlled crosses, at individual level,
showed significant drive through some females for B24 but not for B2, suggesting that this difference in transmission rate might also be important for the substitution process. The analysis
of relative fitness for B2 and B24 carriers for all fitness components, as a whole, showed a significantly better performance of B24-carrying individuals, suggesting that the cumulative effect of these slight differences might contribute to the replacement
of B2 by B24.
Electronic Supplementary Material Supplementary material is available for this article at . 相似文献
30.
Carmen Guillén Ponce María Pilar Garrido López María José Molina Garrido Gema Muñoz Molina Alfredo Carrato 《Clinical & translational oncology》2007,9(1):53-55
Pituitary metastases of solid tumours are infrequent, specially as a first manifestation. When they happen, they are usually
due to breast or lung cancer and are asymptomatic or produce diabetes insipidus. It is very strange that they produce hormonal
deficiency.
We present a case report of a bronchogenic adenocarcinoma in a 65-year-old man which began with panhypopituitarism, diabetes
insipidus and visual alterations. Magnetic resonance imaging revealed a large sellar mass, with clivus infiltration and invading
the right cavernous sinus. The biopsy result was adenocarcinoma metastases from lung cancer. 相似文献