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991.
Francesco Soria Marco Moschini Mohammad Abufaraj Gregory J. Wirth Beat Foerster Kilian M. Gust Mehmet Özsoy Alberto Briganti Paolo Gontero Romain Mathieu Morgan Rouprêt Pierre I. Karakiewicz Shahrokh F. Shariat 《Urologic oncology》2017,35(3):113.e9-113.e14
Purpose
To evaluate the effect of preoperative anemia (PA) on oncological outcomes in a multicenter cohort of patients with non–muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of the bladder (TURB) and adjuvant intravesical therapies. We hypothesize that PA represents a marker of disease aggressiveness and could be used to improve the discrimination of prognostic tools for the prediction of disease recurrence and progression.Methods
This multicenter retrospective study included 1,117 patients from 4 different centers. The presence of PA was assessed according to the World Health Organization classification as a preoperative hemoglobin level of≤13 g/dl in men and≤12 g/dl in women. PA evaluation was done at each institution, generally 1 to 3 days before surgery. Multivariable Cox regression models were performed to evaluate the prognostic effect of PA on survival outcomes.Results
Overall, 381 (34%) patients with NMIBC treated with TURB, had PA. Median follow-up for patients alive at last follow-up was 62.7 months (interquartile range: 25–110.7). On multivariable Cox regression analyses that accounted for the effect of standard clinicopathologic prognosticators, PA was independently associated with recurrence-free survival (P = 0.045) and progression-free survival (P = 0.01). Adding PA to a model for the prediction of disease recurrence and progression improved the discrimination of the prognostic models marginally from 69.8% to 70.3% and from 71.6% to 73.1%, respectively.Conclusions
PA was found in more than one-third of patients with NMIBC treated with TURB. PA was associated with poor oncological outcomes and was an independent predictor of intravesical disease recurrence and progression. However, the additional prognostic information provided by PA remains limited. 相似文献992.
Mohammad Talebpour Donya Sadid Atieh Talebpour Amirsina Sharifi Farzad Vaghef Davari 《Obesity surgery》2018,28(4):996-1001
Introduction
Bariatric surgeries are the only effective long-term treatment in obese patients. The innovation of laparoscopic gastric plication (LGP) raised some questions about its effectiveness compared to traditionally used techniques such as laparoscopic sleeve gastrectomy (LSG). We tried to answer some of these questions.Materials and Methods
We investigated 70 patients in a randomized clinical trial (IRCT2013123012294N5) from 2012 to 2015. Thirty-five patients were randomly assigned to each LSG or LGP group, using sealed envelope method. The body mass index (BMI) reduction and the percentage of excess weight loss (%EWL) along with %total body weight loss (%TWL) were primary endpoint and were assessed at follow-up periods. We recorded postoperative complications, as well.Results
Two-year follow-up rate was 100%. There were no statistically significant differences between the two groups in means of preoperative BMI. Also, postoperative follow-ups were not suggestive for a significant difference in BMI (all p values > 0.05). The mean %EWL at follow-ups showed no significant difference at any point, except for 3 and 6 months after surgery (p value = 0.002 and 0.017, respectively). This finding was confirmed by %TWL trend in 12 months after surgery. LSG patients were readmitted more than LGP patients (seven cases vs one case, p value = 0.024). Postoperative complications such as nausea and vomiting, hair loss, iron deficiency, vitamin D deficiency, and cholelithiasis were not different between the two groups. There was one death in the LGP group due to pulmonary thromboembolism.Conclusions
LGP showed to be efficient regarding %EWL and %TWL reduction in short-term follow-ups with comparable postoperative complications to LSG.993.
994.
995.
Keith D. Calligaro Kwame S. Amankwah Marcus DAyala O. William Brown Paul Steven Collins Mohammad H. Eslami Krishna M. Jain Daniel S. Kassavin Brandon Propper Timur P. Sarac William P. Shutze Thomas H. Webb 《Journal of vascular surgery》2018,67(5):1337-1344
The Hospital Privileges Practice Guideline Writing Group of the Society for Vascular Surgery is making the following five recommendations concerning guidelines for hospital privileges for vascular surgery and endovascular therapy. Advanced endovascular procedures are currently entrenched in the everyday practice of specialized vascular interventionalists, including vascular surgeons, but open vascular surgery remains uniquely essential to the specialty. First, we endorse the Residency Review Committee for Surgery recommendations regarding open and endovascular cases during vascular residency and fellowship training. Second, applicants for new hospital privileges wishing to perform vascular surgery should have completed an Accreditation Council for Graduate Medical Education-accredited vascular surgery residency or fellowship or American Osteopathic Association-accredited training program before 2020 and should obtain American Board of Surgery certification in vascular surgery or American Osteopathic Association certification within 7 years of completion of their training. Third, we recommend that applicants for renewal of hospital privileges in vascular surgery include physicians who are board certified in vascular surgery, general surgery, or cardiothoracic surgery. These physicians with an established practice in vascular surgery should participate in Maintenance of Certification programs as established by the American Board of Surgery and maintain their respective board certification. Fourth, we provide recommendations concerning guidelines for endovascular procedures for vascular surgeons and other vascular interventionalists who are applying for new or renewed hospital privileges. All physicians performing open or endovascular procedures should track outcomes using nationally validated registries, ideally by the Vascular Quality Initiative. Fifth, we endorse the Intersocietal Accreditation Commission recommendations for noninvasive vascular laboratory interpretations and examinations to become a Registered Physician in Vascular Interpretation, which is included in the requirements for board eligibility in vascular surgery, but recommend that only physicians with demonstrated clinical experience in the diagnosis and management of vascular disease be allowed to interpret these studies. 相似文献
996.
Huang G Pashmforoush M Chung B Saxon LA 《Journal of cardiovascular translational research》2011,4(1):61-65
Recent advances in stem cell biology and tissue engineering have put forth new therapeutic paradigms for treatment of myocardial
disease. The aim of stem cell therapy for myocardial regeneration has been directed to induce angiogenesis for ischemic heart
disease and/or introduction of new cardiomyocytes to improve the mechanical function of the failing heart. Encouraged by positive
preliminary results in mouse models of myocardial infarction, clinical trials have utilized autologous skeletal myoblasts
and bone-marrow-derived stem cells to treat patients in various clinical settings including acute myocardial injury, chronic
angina, and heart failure [1–3]. These studies have collectively shown, at best, modest improvement in cardiac function. This may be due to the fact that
there is little evidence to support actual formation and/or integration of transplanted cells into the recipient myocardium.
More recent and emerging data supports the finding that electrical stimulation may be an effective catalyst for sustained
functional organization, integration, and maturation of transplanted cell populations into the host myocardium. A therapeutic
model that utilizes electrical stimulation and/or achieves cardiac resynchronization in conjunction with stem cell transplantation
may be an effective means to achieve successful myocardial regenerative therapy. 相似文献
997.
Immunoglobulin G4‐related disease (Ig4RD) is an inflammatory condition with unique clinical, serological, and pathological features. In this study, we report a challenging diagnostic clinical case of Ig4RD diagnosed based on histopathology. This unique imitating nature reinforces that it is crucial to consider the diagnosis of IgG4‐RD in those presenting with pachymeningitis. 相似文献
998.
Manal Ahmad Abbas Yasser Ibrahim Kandil Manal Mohammad Abbas 《Journal of traditional Chinese medicine》2021,(2):270-275
OBJECTIVE:To investigate the efficacy of the ex-tract from Ononis spinosa L.(O.spinosa)on etha-nol-induced gastric ulcer in rats.METHODS:Phytochemical constitue... 相似文献
999.
Rahimeh Abdoli Hasan Bakhshi Sedigheh Kheirandish Faezeh Faghihi Asadollah Hosseini-Chegeni Mohammad Ali Oshaghi Zakkyeh Telmadarraiy Mohammad Mehdi Sedaghat 《Asian Pacific journal of tropical medicine》2021,(5):223-230
Objective: To estimate the infection of ticks to Anaplasma, Ehrlichia, Babesia, Theileria, and Brucellaceae using molecular methods in borderline of Iran, Azerbaijan, and Armenia.Methods: Totally, 2 022 ticks were collected from different livestock. Then, species were diagnosed under stereomicroscope according to valid morphological keys. Tick DNA was extracted followed by PCR to detect Anaplasma, Ehrlichia, Theileria, Babesia and Brucellaceae infection in ticks. Results: A total of 498 males [24.62%(95% CI 22.76%-26.57%)], 741 females [36.64%(95% CI 34.54%-38.79%)], 782 nymphs [38.67%(95% CI 36.55%-40.84%)] and 1 larva [0.04%(95% CI 0.00%-0.28%)] were identified. Among identified samples, we found four genera including Hyalomma, Rhipicephalus, Haemaphysalis, and Dermacentor. Molecular assay revealed that the prevalence of ticks to Anaplasma or Ehrlichia, and Brucellaceae was 22.02%(95% CI 16.01%-29.06%) and 15.03%(95% CI 9.43%-22.26%), respectively. Phylogenetic analysis showed that the identified Anaplasma sp. had the most similarity with Anaplasma centrale, Anaplasma platys, Anaplasma camelii, and Anaplasma phagocytophilum, submitted in Gen Bank. Furthermore, the detected Ehrlichia sp. and Brucellaceae bacterium had the most similarity with Ehrlichia ruminantium and Mycoplana peli, respectively. However, no sign of the presence of Theileria and Babesia spp. was seen in the studied samples. Conclusions: Anaplasmosis, ehrlichiosis and brucellosis should be considered as important health threats in northwestern Iran and consistent monitoring on infection of ticks and livestock should be performed regularly. 相似文献
1000.
Dorsa Rostampour Mohammad Reza Zolfaghari Milad Gholami 《Journal of clinical laboratory analysis》2022,36(3)
BackgroundInfantile neuroaxonal dystrophy is an autosomal recessive neurological disorder. Individuals with infantile neuroaxonal dystrophy experience progressive loss of vision, mental skills and muscular control, and other variable clinical signs. Pathogenic variants in the PLA2G6 gene, encoding phospholipase A2, are recognized to be the fundamental reason for infantile neuroaxonal dystrophy. This study aimed to detect pathogenic variant in a consanguine Iranian family with infantile neuroaxonal dystrophy.MethodsThe mutation screening was done by whole exome sequencing followed by direct Sanger sequencing.ResultsWe identified a homozygous insertion mutation, : c.1548_1549insCG (p.G517Rfs*29) in exon 10 of PLA2G6 in the patient. The parents were heterozygous for variant.ConclusionsBecause of the clinical heterogeneity and rarity of infantile neuroaxonal dystrophy, whole exome sequencing is critical to confirm the diagnosis and is an excellent tool for INAD management. NM_003560相似文献