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971.
972.
Yi Li Kevin McIntosh Jieli Chen Chunling Zhang Qi Gao Jade Borneman Kim Raginski James Mitchell Lihong Shen Jing Zhang Dunyue Lu Michael Chopp 《Experimental neurology》2006,198(2):313
We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial–axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI – or syngeneic Wistar –bone marrow stromal cells at 24 h after ischemia and sacrificed at 28 days. Significant functional recovery was found in both cell-treated groups compared to stroke rats that did not receive BMSCs, but no difference was detected between allogeneic and syngeneic cell-treated rats. No evidence of T cell priming or humoral antibody production to marrow stromal cells was found in recipient rats after treatment with allogeneic cells. Similar numbers of Y-chromosome+ cells were detected in the female rat brains in both groups. Significantly increased thickness of individual axons and myelin, and areas of the corpus callosum and the numbers of white matter bundles in the striatum were detected in the ischemic boundary zone of cell-treated rats compared to stroked rats. The areas of the contralateral corpus callosum significantly increased after cell treatment compared to normal rats. Processes of astrocytes remodeled from hypertrophic star-like to tadpole-like shape and oriented parallel to the ischemic regions after cell treatment. Axonal projections emanating from individual parenchymal neurons exhibited an overall orientation parallel to elongated radial processes of reactive astrocytes of the cell-treated rats. Allogeneic and syngeneic bone marrow stromal cell treatment after stroke in rats improved neurological recovery and enhanced reactive oligodendrocyte and astrocyte related axonal remodeling with no indication of immunologic sensitization in adult rat brain. 相似文献
973.
我国每年有两千万新生儿出生,约有2万~6万新生儿患有听力障碍,远高于目前已开展的两病筛查(先天性甲状腺功能低下1:7000,苯丙酮尿症1:16500)。开展新生儿听力筛查,是一项社会意义重大的优生工程。本院已将新生儿听力筛查作为重点工作,由专职听力筛查的儿科医生和主管护师共同承担此项工作,并对患儿进行追踪随访,为早诊断、早干预提供帮助,同时调查家长对筛查结果的评价。现介绍如下。 相似文献
974.
目的 探讨黄芪注射液穴位注射结合中药外洗治弃疣的疗效。方法 将169例疣患者随机分为治疗组(92例)和时照组(77例)。对照组用聚肌胞注射液肌内注射,治疗组采用黄芪注射液穴位注射及苡仁、板蓝根、莪术等中药外洗。结果 治疗组有效率90.22%.对照组有效率68.83%.两组比较,差异有显著性意义(P〈0.01)。结论 穴位注射结合中药外洗治疗疣效果良好.且方法简单。 相似文献
975.
Meng-Luen Lee Hsiao-Neng Chen Ming Chen Lon-Yen Tsao Bao-Tyan Wang Mei-Hui Lee Ing-Sh Chiu 《台湾医志》2006,105(4):284-289
BACKGROUND: Chromosome 22q11.2 deletion is frequently associated with conotruncal malformations and aortic arch anomalies. This study investigated the association of chromosome 22q11.2 deletion with clinical manifestations in four pediatric patients with persistent fifth aortic arch. METHODS: Four patients with persistent fifth aortic arch treated between July 1997 and June 2004 were included in this retrospective study. There were two girls and two boys, aged 2 days to 11.3 years, with persistent fifth aortic arch and cardiac conotruncal malformations. Chart recordings, plain chest films, two-dimensional and Doppler echocardiograms, cardiac catheterization with angiograms, surgical findings, and cytogenetic study were analyzed. RESULTS: Clinically, all four patients had the cardinal phenotypic features of 22q11.2 deletion syndrome, including cardiovascular malformations (conotruncal malformations and aortic arch anomalies), abnormal facies, thymic hypoplasia, canopy anomaly of the palate (high-arched palate, rather than cleft palate), and hypocalcemia (or hypoparathyroidism). All four patients were confirmed to have chromosome 22q11.2 deletion. CONCLUSION: Congenital conotruncal malformations, including tetralogy of Fallot with pulmonary atresia or stenosis, and aortic arch anomalies including a persistent fifth aortic arch or a right aortic arch, should lead to suspicion of chromosome 22q11.2 deletion when manifested together with any one of the other four cardinal phenotypic features. 相似文献
976.
提高产科休克的处置水平降低孕产妇死亡率 总被引:3,自引:1,他引:2
休克是指由各种原因所导致的有效循环血容量减少、破坏机体内环境稳定,引起了微循环障碍,影响重要脏器组织血液灌注所出现的临床综合征,产科休克是指与妊娠及分娩因素直接有关的休克,是产科领域中一种急性而严重的并发症,目前仍然为导致孕产妇死亡的重要原因.因此,提高所有妇产科医务人员对产科休克的认识及临床处置水平是降低我国孕产妇死亡率的关键,亦是我们妇产科医师当前的主要任务. 相似文献
977.
21世纪。我国护理教学改革已经进入了新的发展时期,尤其是国家教育部和卫生部联合组织的《面向21世纪高等医学教育课程体系建设和改革》课题的广泛实施,极大地促进了医学和护理教育的发展。高等护理教育课程作为达到教育目的的主要手段,必须加以改革与创新,要着眼于21世纪发展趋势与要求,以学生的发展为本,把学生身心全面发展和个性、潜能发展作为核心,充分借鉴已有的课程改革实践经验和成果,培养符合21世纪需要的高层次护理人才。在当前推行以人为本的整体护理背景下,现代护理教育越来越重视培养学生的探索精神、科研精神、创新精神,通过研究改进护理工作和提高对病人的护理。这也正和分组式教学的功能相吻合。为了充分发挥该模式对护理人才培养的作用,对其理论基础以及在护理教育领域中的教学程序、教学效果进行探讨是很有必要的。 相似文献
978.
中国心理咨询发展的历史回顾与前景趋势 总被引:3,自引:0,他引:3
目的:回顾心理咨询在中国产生、发展的历史和现状,提出存在的问题和不足,展望21世纪心理咨询发展的前景和趋势。
资料来源:通过整理专家专题讲座笔记和手工查阅与心理咨询相关的资料,检索词“心理咨询”,并限定文章语言种类为中文。
资料选择:对资料进行初审,选取心理咨询文献开始查找全文。纳入与心理咨询相关的研究。
资料提炼:根据国内外关于心理咨询的研究资料和印刷品资源中心理咨询相关资料进行归纳和概括,提取相关资料并进行整合。纳入与国外心理咨询历史发展和生态学有关,与中国心理咨询发展与现状有关的资料。
资料综合:心理咨询在发达国家虽然已有近百年的历史,但在中国才刚刚起步阶段,广大心理咨询工作者经过近20多年的不懈地努力。心理咨询理论和方法虽然有了雏形,还需要进一步的完善。
结论:借鉴国外心理咨询发展的新理论和新方法,是发展中国心理咨询理论与方法的有效途径。可以认为,生态观将成为21世纪心理咨询发展的大趋势之一。 相似文献
979.
颈椎病的影像学检查及其临床意义 总被引:1,自引:0,他引:1
目的探讨颈椎病的临床及影像学表现,以期提高对本病的认识。方法对86例颈椎病X线,CT,MR影像学表现进行分析。结果86例中,颈椎病主要影像学改变为颈椎生理曲度异常,椎体和钩突关节骨质增生,椎间隙变窄,椎管狭窄和颈部韧带骨化。结论颈椎病影像学改变具有一定的特征性,有助于颈椎病的诊断,为临床治疗提供了依据和参考价值。 相似文献
980.
What is the prognostic value of myocardial perfusion imaging using rubidium-82 positron emission tomography? 总被引:5,自引:0,他引:5
Keiichiro Yoshinaga Benjamin J W Chow Kathryn Williams Li Chen Robert A deKemp Linda Garrard Alexander Lok-Tin Szeto May Aung Ross A Davies Terrence D Ruddy Rob S B Beanlands 《Journal of the American College of Cardiology》2006,48(5):1029-1039
OBJECTIVES: The objective was to determine the prognostic value of rubidium-82 (82Rb) positron emission tomography (PET) myocardial perfusion imaging (MPI). BACKGROUND: 82Rb PET MPI accurately diagnoses coronary artery disease (CAD). However, there are limited data evaluating its prognostic value. METHODS: Follow-up (3.1 +/- 0.9 years) was obtained in 367 patients who underwent dipyridamole 82Rb PET MPI. Patients were divided into groups based on their summed stress score (SSS): group I, normal (<4); group II, mild (4 to 7); and group III, moderate (8 to 11) to severe (> or =12). RESULTS: There were significant differences among patients in the 3 SSS groups for hard events (cardiac death and myocardial infarction [MI]) (p < 0.001) and total cardiac events (hard events, revascularization and hospitalization) (p < 0.001). The annual hard events rates were 0.4%, 2.3%, and 7.0% in the normal, mild, and moderate-severe groups, respectively. In adjusted survival models, 82Rb PET SSS was the strongest predictor of total cardiac events and a significant predictor of hard events. Among patients referred for PET after 99mTc single-photon emission computed tomography, the annual total event rate was higher with abnormal versus normal SSS on PET (15.2% vs. 1.3%, p < 0.001). In patients with obesity, the annual total event rate was 11.1% with an abnormal scan and 1.5% with a normal scan (p < 0.001). CONCLUSIONS: This study shows that 82Rb PET MPI has significant prognostic value for predicting cardiac events, including death and MI. It also seems to have prognostic value in patients whose diagnosis remains uncertain after single-photon emission computed tomography MPI and in obese patients. The prognostic value of PET MPI may improve the management of cardiac patients. 相似文献