全文获取类型
收费全文 | 281437篇 |
免费 | 13335篇 |
国内免费 | 663篇 |
专业分类
耳鼻咽喉 | 3583篇 |
儿科学 | 8676篇 |
妇产科学 | 6128篇 |
基础医学 | 40089篇 |
口腔科学 | 6489篇 |
临床医学 | 22280篇 |
内科学 | 62773篇 |
皮肤病学 | 7368篇 |
神经病学 | 25573篇 |
特种医学 | 8670篇 |
外国民族医学 | 106篇 |
外科学 | 34203篇 |
综合类 | 1272篇 |
一般理论 | 76篇 |
预防医学 | 25820篇 |
眼科学 | 5317篇 |
药学 | 19741篇 |
中国医学 | 845篇 |
肿瘤学 | 16426篇 |
出版年
2023年 | 1577篇 |
2022年 | 2082篇 |
2021年 | 5456篇 |
2020年 | 3023篇 |
2019年 | 5333篇 |
2018年 | 10078篇 |
2017年 | 6511篇 |
2016年 | 6056篇 |
2015年 | 6589篇 |
2014年 | 7526篇 |
2013年 | 11542篇 |
2012年 | 18980篇 |
2011年 | 19039篇 |
2010年 | 9880篇 |
2009年 | 7770篇 |
2008年 | 16108篇 |
2007年 | 17049篇 |
2006年 | 15731篇 |
2005年 | 15536篇 |
2004年 | 14522篇 |
2003年 | 13342篇 |
2002年 | 12580篇 |
2001年 | 6935篇 |
2000年 | 7066篇 |
1999年 | 6269篇 |
1998年 | 1386篇 |
1997年 | 1101篇 |
1996年 | 1003篇 |
1995年 | 902篇 |
1992年 | 3580篇 |
1991年 | 3171篇 |
1990年 | 3045篇 |
1989年 | 2765篇 |
1988年 | 2577篇 |
1987年 | 2449篇 |
1986年 | 2297篇 |
1985年 | 2084篇 |
1984年 | 1544篇 |
1983年 | 1315篇 |
1979年 | 1342篇 |
1978年 | 958篇 |
1977年 | 901篇 |
1975年 | 908篇 |
1974年 | 1095篇 |
1973年 | 1110篇 |
1972年 | 1042篇 |
1971年 | 1019篇 |
1970年 | 943篇 |
1969年 | 977篇 |
1968年 | 877篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
M. Masson Regnault J. Castañeda-Sanabria M.H.T. Diep Tran M. Beylot-Barry H. Bachelez N. Beneton O. Chosidow A. Dupuy P. Joly D. Jullien E. Mahé M.-A. Richard M. Viguier F. Tubach E. Sbidian C. Paul The PsoBioTeq Study Group 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):293-300
62.
Martina A. Steurer Jean Costello Rebecca J. Baer Scott P. Oltman Sky K. Feuer Tania Pacheco-Werner Elizabeth Rogers Marta M. Jankowska Jessica Block Molly McCarthy Matthew S. Pantell Christina Chambers Kelli K. Ryckman Laura L. Jelliffe-Pawlowski 《Paediatric and perinatal epidemiology》2020,34(2):130-138
63.
64.
65.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献66.
Modena Débora Aparecida Oliveira Miranda Ana Carolina Godoy Grecco Clovis Liebano Richard Eloin Cordeiro Raquel Cristina Tancsik Guidi Renata Michelini 《Lasers in medical science》2020,35(4):797-806
Lasers in Medical Science - Using light sources in phototherapy has presented promising results regarding several types of facial and body skin affections for centuries. The neodymium-doped yttrium... 相似文献
67.
Duds Eszter Susa va Pamjav Horolma Szabolcsi Zoltn 《International journal of legal medicine》2020,134(2):487-489
International Journal of Legal Medicine - Gyula Ágner was a Royal Hungarian First Lieutenant (1st Lt.) during the World War II and died at 30 years old due to a mine shrapnel injury... 相似文献
68.
Abdelhadi Lahoum Nasserdine Sabaou Christian Bijani Noureddine Bouras Frédéric Pont Selma P. Snini Florence Mathieu 《Saudi Pharmaceutical Journal》2019,27(1):56-65
The actinobacterium strain ABH26 closely related to Saccharothrix xinjiangensis, isolated from an Algerian Saharan soil sample, exhibited highly antagonist activity against Gram-positive bacteria, yeasts and filamentous fungi. Its ability to produce antimicrobial compounds was investigated using several solid culture media. The highest antimicrobial activity was obtained on Bennett medium. The antibiotics secreted by strain ABH26 on Bennett medium were extracted by methanol and purified by reverse-phase HPLC using a C18 column. The chemical structures of the compounds were determined after spectroscopic (1H NMR, 13C NMR, 1H-1H COSY and 1H-13C HMBC spectra), and spectrometric (mass spectrum) analyses. Two new cyanogriside antibiotics named cyanogriside I (1) and cyanogriside J (2), were characterized along with three known caerulomycins, caerulomycin A (3), caerulomycin F (4) and caerulomycinonitrile (5). This is the first report of cyanogrisides and caerulomycins production by a member of the Saccharothrix genus. The minimum inhibitory concentrations (MIC) of these antibiotics were determined against pathogenic microorganisms. 相似文献
69.
70.
H. Wessling C. L. Simosono M. Escosa-Bagé P. de las Heras-Echeverría 《Acta neurochirurgica》2006,148(6):673-675
Summary We present a case of blindness and Anton’s syndrome in a psychiatric patient with late diagnosis of a giant frontal meningioma.
The criteria for advanced diagnostic imaging in the psychiatric population are discussed. We conclude that MR or CT scan is
indicated in psychiatric in-patients who fail to improve with standard psychiatric treatment. This strategy should be submitted
to a cost-benefit analysis. 相似文献