Interaction of misonidazole, hyperthermia, and irradiation in a C3H mammary carcinoma and its surrounding skin in vivo.

The interaction of irradiation, Misonidazole (MISO), and hyperthermia was studied in a C3H mouse mammary carcinoma and its surrounding skin in vivo. MISO (0.5-1.0 mg/g) was injected 30 min before irradiation. Hyperthermia (41.5 degrees-43.5 degrees C for 60 min) was given either simultaneously, 0.5 hr, or 4 hr after X rays. The results were evaluated as the radiation dose to achieve tumor control (TCD50) or moist desquamation of the skin (DD50) in half of the treated animals. A therapeutic gain was found when the enhancement in tumors were greater than that found in skin. The combination of simultaneous heat and irradiation caused great enhancement in radiation response, but with no therapeutic gain. A slightly lower enhancement of the damage in both tissues was found with a 30 min interval between irradiation and hyperthermia, whereas heat 4 hr after X rays gave a small, but significant therapeutic gain. MISO significantly enhanced the response in tumors but not in skin. Combined trimodality treatment with MISO, irradiation, and hyperthermia resulted in enhancement ratios up to 15, dependent on temperature, radiation-heat interval, and to a lesser extent the MISO dose. The enhancement was for all schedules most pronounced in the tumors, resulting in an improved therapeutic effect. The combination of MISO and hyperthermia may be a valuable addition to radiotherapy, especially if heat and irradiation can be applied with close interval and with one of the modalities given selectively to the tumor.     

后颅窝转移瘤

Twenty-seven cases of metastatic tumor of posterior fossa were presented in this paper. Of the patients, 20 were males and 7 females; their age ranged from 20 to 68, and 89% of them were over 40 years of age. The primary foci found were bronchopulmonary carcinomas (7 cases), rhinopharyngeal carcinomas (3 cases), and cancer of the liver (1 case), but in 16 cases the primary foci were not found. All of these patients presented symptoms and signs of obviously increased intracranial pressure, and most of them had the signs of cerebellar and cranial nerves' lesions. Ventriculorgraphy and brain CT scanning were important procedures in the diagnosis, and MRI was most valuable in establishing the diagnosis and localization of posterior fossa metastatic tumors. Twenty-six patients underwent operation. The short-term follow-up study showed an improvement in 25 cases. There was one death. The surgical treatment of posterior fossa metastatic tumor was emphasized. Radiotherapy and chemotherapy were discussed.     

肾移植受者血清巨细胞病毒IgE和IgA抗体检测

采用间接ＥＬＩＳＡ检测２３名肾移植受者血清巨细胞病毒（ＣＭＶ）抗体，共检出１８名（７８％）活动性ＣＭＶ感染，其中１０名（４４％）为原发性感染。结果证实ＣＭＶ－ＩｇＥ和－ＩｇＡ具有较好的血清学诊断价值，优于ＣＭＶ－ＩｇＭ。     

白城市52年间法定报告传染病流行趋势分析

目的：了解掌握法定报告传染病流行情况及变化。方法：采用描述流行病学方法，分析报告传染病的消长分布。结果：传染病的发病率，死亡率，病死率都呈显著下降趋势，病种间消长有明显变化。结论：血源及性传播疾病为新时期的主要传染病病种。     

GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing

The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD). GGA1, a member of the Golgi-localized gamma-ear-containing ARF-binding (GGA) protein family, interacts with BACE and influences its subcellular distribution. We now report that overexpression of GGA1 in cells increased the APP C-terminal fragment resulting from beta-cleavage but surprisingly reduced Abeta. GGA1 confined APP to the Golgi, in which fluorescence resonance energy transfer analyses suggest that the proteins come into close proximity. GGA1 blunted only APP but not notch intracellular domain release. These results suggest that GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. GGA1 may act as a specific spatial switch influencing APP trafficking and processing, so that APP-GGA1 interactions may have pathophysiological relevance in AD.     

门诊干扰素治疗慢性乙型病毒性肝炎病人数据库的建立及其应用

报道了应用计算机对感染内科门诊干扰素治疗慢性乙型病毒性肝炎病人的一般资料、干扰素治疗方案、干扰素治疗效果、干扰素副反应、每次复查的生化结果、随访的时间等项目建立数据库,设计程序进行管理。微机能准确地储存资料,方便医护人员对门诊干扰素治疗病人进行及时、有效的治疗和管理,促进病人的健康,提高医护人员的科学管理和社区保健的能力。     

Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

BACKGROUND: A recent report provided evidence that a disintegrin and metalloprotease domain 33 (ADAM33), a member of the ADAM family, is a novel susceptibility gene in asthma linked to bronchial hyper-responsiveness. However, there has been no investigation of the genetic role of ADAM33 variants in nasal allergy. OBJECTIVE: The purpose of this study was to test the association between ADAM33 polymorphisms and Japanese cedar pollinosis (JCPsis), a most common seasonal allergic rhinitis in Japan. METHODS: We conducted a case-control association study among a Japanese population, involving 95 adult individuals with JCPsis and 95 normal healthy controls. A total of 22 single-nucleotide polymorphisms (SNPs) in ADAM33 were genotyped using PCR-based molecular methods. RESULTS: Six SNPs of ADAM33 gene, three in introns (7575G/A, 9073G/A and 12540C/T) and three in the coding region (10918G/C, 12433T/C and 12462C/T), were strongly associated with JCPsis (P = 0.0002-0.022 for absolute allele frequencies) and most of the SNPs were in linkage disequilibrium with each other. A higher frequency of the common alleles of these SNPs was noted for the subjects with JCPsis in comparison with healthy controls. We also identified a haplotype associated with the disease susceptibility. In addition, associations were found between ADAM33 polymorphisms and various cedar pollinosis phenotypes including clinical severity, eosinophil counts in nasal secretion and allergen-specific IgE levels in sera, but not total serum IgE levels. CONCLUSION: These results indicate that polymorphisms in the ADAM33 gene are associated with susceptibility to allergic rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.     

SOLIS在颈椎前路融合术中的应用

目的 探讨新型颈椎前路融合器(SOLIS)在颈椎前路融合术中的应用效果.方法 对18例脊髓型颈椎病、12例颈椎间盘突出症采用颈椎前路减压融合术,小切口入路(3～4 cm),椎间盘及部分椎体后缘切除后保留椎体终板,植人带自体松质骨的SOLIS.以手术前后X线片及JOA评分评价疗效.结果 30例随访6～18个月,平均12.5个月.置人的SOLIS位置良好,无移动及脱出迹象;病变椎间隙高度恢复正常,未见椎间高度丢失;所有节段均于术后3～8个月骨性融合.术前JOA评分平均10.4分,术后平均14.9分,两者有统计学意义(P＜0.01).结论 颈椎前路融合器SOLIS具有良好的生物相容性,手术创伤小,能有效地恢复颈椎高度,融合率高,融合后稳定性好,神经功能改善优良率高.