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111.
CELL KINETIC STUDIES IN MIXED LEUKOCYTE CULTURES: AN in vitro MODEL OF HOMOGRAFT REACTIVITY 总被引:13,自引:0,他引:13 下载免费PDF全文
Fritz H. Bach Harvey Bock Kenneth Graupner Elizabeth Day Heidi Klostermann 《Proceedings of the National Academy of Sciences of the United States of America》1969,62(2):377-384
The recognition phase of homograft immunity can be studied in vitro in the mixed leukocyte culture reaction. In this reaction, at the end of seven days, up to 30 per cent of the lymphocytes in culture "respond" to a single allogeneic cell stimulus. This paper presents evidence that the lymphocytes responding in culture divide with the generation time of 18-21 hours, with some asynchrony, and that a large percentage of the cells found at the end of the culture period may be the products by division of a small number of cells initially responding. Two estimates are made of the frequency of the initially responding unit (the cell(s) responsible for initiating the response). These are probably minimum estimates and are in the range of 1 in 200 to 1 in 2000 cells which can initially respond. This very high frequency of responding units as compared with the responding units in immediate type hypersensitivity (antibody production) is discussed. 相似文献
112.
K. Graupner F. Müller 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1966,171(2):103-104
Zusammenfassung p-Fluorphenylalanin wurde an 32 Patienten mit, einer Keratitis dendritica vergleichend zu 5-Jodo-2-desoxyuridin untersucht und als gleichermaßen wirksam gefunden. Sein therapeutischer Wert kann erst nach einer längeren Nachbeobachtungszeit endgültig festgestellt werden.
Summary p-Fluorphenylalanin and 5-Jodo-2-desoxyuridin were investigated on 32 patients with Keratitis dendritica. Both substances showed the same good effect.相似文献
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H J Gabius R Engelhardt J Casper D Reile S Schumacher H J Schmoll G Graupner F Cramer 《Tumour biology》1985,6(2):145-156
Fractionation of detergent extracts of transplanted tumors of human teratocarcinoma cells by affinity chromatography yields one predominant protein with apparent molecular weight of 14,000 and further, for less abundant protein with apparent molecular weight of 35,000 from lactose-sepharose and one protein with apparent molecular weight of 68,000 from mannan-sepharose. No further carbohydrate-binding protein can be isolated on columns derivatized with asialofetuin, melibiose and L-fucose, to which the extract is applied successively. Both proteins agglutinate trypsinized, glutaraldehyde-fixed rabbit erythrocytes in the absence of Ca2+ and can thus be defined as endogenous human teratocarcinoma lectins. Inhibition of heterotypic and homotypic aggregation of human teratocarcinoma cells by D-mannose, D-galactose and glycoproteins rich in one of these sugars is consistent with a functional role of these Ca2+-independent lectins in cell aggregation. Visualization of these activities by fluorescent mannosylated and lactosylated markers on the cell surface further supports the cell surface localization of these detergent extractable lectins. The mannan-specific lectin, in particular, has so far not been detected in any mammalian tissue or tumor and is of potential value for a lectin-based diagnosis and therapy of embryonal carcinomas. 相似文献
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K. Graupner S. Klein F. Müller 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1969,177(2):89-96
Zusammenfassung Bei 69 Patienten mit einer Keratitis dendritica wurde die Behandlung mit einer Jodabrasio eingeleitet und dann mit Panthenol-, IDU-, pFPA oder einer IDU-pFPA-Mischsalbe fortgesetzt. Die Ausführung einer Jodabrasio vor der Salbenbehandlung verkürzte die Behandlungszeit erheblich. Von den zur Nachbehandlung verwendeten Salben war die Mischsalbe die beste. Weiterhin erwies sich pFPA-Augensalbe als geeignet, während IDU- und Panthenol-Augensalbe einen weniger günstigen Effekt zeigten.
Für die Herstellung der Alnasid-Augensalbe sind wir Herrn Apotheker Luchterhand) von der Klinikapotheke der Medizinischen Akademie zu besonderem Dank verpflichtet. 相似文献
Investigation about the efficiency of non specific and virostatic therapy of the Keratitis dendritica with specific reference of the combination of 5-Jod-2-deoxyuridine and para-Fluorphenyl-alanin
Summary The treatment of 69 patients with typical dendritic keratitis was started with an iodization of the affected areas of the cornea and continued with an ointment containing Panthenol, para-Fluorphenylalanin (pFPA), 5-Jodo-2-deoxyuridine (IDU) or a mixture of the last two. Iodization before the treatment with an ointment passed away the time of application. The mixed ointment has been shown to be the best. The therapy with pFPA-ointment had also good results, whereas Panthenol- and IDU-ointment had no favourable effect.
Für die Herstellung der Alnasid-Augensalbe sind wir Herrn Apotheker Luchterhand) von der Klinikapotheke der Medizinischen Akademie zu besonderem Dank verpflichtet. 相似文献
117.
O. K. Graupner E. V. Kálmán G. F. le Petit 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1971,182(4):351-356
Zusammenfassung Früher berichtete Untersuchungsergebnisse führten zu der Annahme, daß bio- bzw. physikochemische Eigenschaften der Hornhaut deren Schutzfunktion wesentlich bestimmen. In der vorliegenden Arbeit werden Ergebnisse von Versuchen berichtet, die durchgeführt wurden mit dem Ziel, die Pufferkurven von Hornhaut und Kammerwasser durch Titration zu bestimmen. Es konnte festgestellt werden, daß die Pufferkapazität des Kammerwassers erheblich größer ist als die des Hornhautgewebes. Sowohl Hornhaut als auch Kammerwasser pufferten Säure etwa doppelt so gut ab wie Lauge. Es wird vermutet, daß die Pufferkapazität von Hornhaut und Kammerwasser der Faktor ist, der von seiten des Auges die Größe der Schädigung nach Verätzung entscheidend bestimmt.
The importance of the buffer properties of cornea and aqueous humor in the protection of the eye burned with acid or base
Summary In a former paper it was suggested that also the buffer properties of the cornea have a protective function in eyes burned with acid or base. In this investigation the buffer curve of cornea and aqueous humor was determined by titration with HCl or NaOH in a concentration of 0.01 Val/l. The results showed, that the effectiveness of the buffer systems of aqueous humor is better than that of the cornea. The buffer action of both aqueous humor and cornea against an acid was about twice of that against a base. It is suggested that the buffer capacity essentially determines the extension of the damage in eyes burned with acid or base.相似文献
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Viktoria?BauEmail author Maike?Sievert Peter?Roggenk?mper Stephan?Zierz 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2005,243(10):1062-1065
Background Cyclic strabismus is a rare disorder in which strabismus and orthotropia regularly alternate over a period of mostly 48 h.
It may occur spontaneously, upon squint surgery, or in association with lesions of the central nervous system. In most cases
the deviations are convergent.
Methods Clinical case report.
Results A 34-year-old woman with bilateral recurrent ocular myositis for 2 years had developed cyclic vertical deviation 6 months
after clinical remission. A hypotropia of the left eye alternated with an orthotropia, following a 48-h rhythm. Three months
after recession of the inferior rectus muscle the alternating squint had disappeared.
Discussion The aetiology of cyclic eye deviations, most of them occurring in a constant rhythm, is not known. The association with lesions
of the central nervous system indicates a primary central dysregulation of a “biological clock”. Their well-known occurrence,
however, after squint surgery and, as in the present case, after orbital myositis, suggests that alteration of peripheral
structures may contribute to a central dysregulation. Squint surgery seems to be the treatment of choice, even in rare cases
with vertical deviations.
Presented at the DOG, Berlin, 2003 相似文献