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11.
12.
Laura Daly Williams RN 《Sexuality and disability》1992,10(2):125-126
Reprinted from Sexuality Update, a publication of The National Task Force On Sexuality and Disability of the American Congress of Rehabilitation Medicine, Vol 2, No. 1, 1989. 相似文献
13.
K Daly G S Giebink P B Batalden R S Anderson C T Le B Lindgren 《The Pediatric infectious disease journal》1991,10(7):500-506
This double blind, placebo-controlled trial was designed to determine whether intervention with a stepped regimen of trimethoprim-sulfamethoxazole (TMP-SMX) and prednisone would prevent high risk children from developing chronic otitis media with effusion (OME) and recurrent acute otitis media. Forty-two children were enrolled, assigned to treatment with active drug or placebo and then examined at 2-week intervals. They received TMP-SMX (or placebo) during the first 2 weeks, TMP-SMX and prednisone (or placebo) during Weeks 3 and 4 for persistent OME and TMP-SMX (or placebo) for Weeks 5 and 6 if OME was still unresolved. After treatment 48% of active drug and 14% of placebo subjects resolved OME bilaterally (P less than 0.05). Active drug subjects also had fewer acute otitis media episodes than placebo subjects while receiving study treatment (P less than 0.01). Although this treatment regimen produced short term OME resolution, long term benefits were not demonstrated. 相似文献
14.
Paul P. Dillon Stephen J. Daly John G. Browne Bernadette M. Manning Elma Loomans Aart Van Amerongen Richard O'Kennedy 《Food and Agricultural Immunology》2003,15(3):225-234
Public concern surrounding antibiotic contamination in food and food products has made it imperative to develop analytical methods for their detection. Polyclonal antibodies were used in the development of a surface plasmon resonance (SPR)-based inhibition immunoassay for cephalexin. A conjugate consisting of cephalexin-bovine serum albumin (BSA) was immobilized on the dextran gel surface of the sensor chip. Binding/regeneration studies of antibody to immobilized cephalexin were studied and dissociation of the antibody from the immobilized cephalexin was easily achieved with 10 mmol l-1 NaOH. Forty surface regeneration cycles were carried out and found to be reproducible with only a 7.4% decrease in binding over this number of regenerations. Model inhibition immunoassays for cephalexin were developed in PBS and spiked milk samples with detection ranges of 4.88 to 2,500 ng ml-1 and 244 to 3,906 pg ml-1, respectively. 相似文献
15.
16.
Obesity: A public health problem in Ireland? 总被引:1,自引:0,他引:1
We examined the prevalence of different categories of body weight in a random sample of men and women aged 35 to 64 years
studied in 1985 in County Kilkenny, Ireland. The largest group was those classified as overweight — 51.1% of men and 44.7
% of women. There were 13.7 % of men and 19.2% of women in the obese category. The obese were older but the distribution by
social class did not differ significantly from the non-obese. Obese women had significantly more children born alive and a
higher prevalence of positive angina questionnaire than those who were not obese.
Serum total cholesterol was higher in obese men and HDL cholesterol was lower in obese men and obese women. Systolic and diastolic
blood pressures were significantly higher in obese men and women but smoking status was similar. In a multiple logistic regression
analysis, systolic blood pressure in men and diastolic in women remained significantly associated with obesity; there was
an inverse association between obesity and HDL cholesterol in women and between obesity and HDL-cholesterol as a proportion
of total cholesterol in men. 相似文献
17.
L. M. Franco C. C. Daly D. Chilongozi G. Dallabetta 《Bulletin of the World Health Organization》1997,75(6):523-532
This article examines the reliability and validity of direct observation of patient-provider encounters, interviews with providers, and use of patients simulating sexually transmitted diseases (STD) as methods for assessing the quality of STD case management in developing countries. Data were collected during an STD health facility survey in Malawi; the performance of 49 providers was observed, and the providers were also interviewed; 20 of them were visited by a simulated patient complaining of urethral discharge. Agreement (based on the kappa statistic) was generally poor between direct observation and provider-interview data, and also between direct observation and simulated-patient data. In contrast, percentage agreements between direct observation and simulated-patient data were often high. Multiple observations on providers indicated that a provider''s behaviour is not consistent across several patients. Simulated-patient data are probably the best in reflecting normal performance, but their feasibility for routine quality assessment is limited because the provider''s behaviour is not consistent and would require multiple data points. Direct observation data are the best option for assessing quality if the results are assumed to reflect better than normal levels of quality of care. Data from interviews with providers should be viewed with caution, because they may reflect provider knowledge and not necessarily performance. 相似文献
18.
Effects of laparotomy on systemic macrophage function. 总被引:3,自引:0,他引:3
Surgical trauma induces immunosuppression that may adversely influence survival. This study examined the effect of laparotomy on two different macrophage populations, peritoneal macrophages (PM phi) and Kupffer cells. Female, 6- to 8-week old, CFW/C3H-HeN mice (n = 160) were randomly allocated to one of three study groups: control, ether anesthetic only, or ether anesthetic and laparotomy. On postoperative days 1 and 3, PM phis and Kupffer cells were harvested and assayed for superoxide anion production (O2-), percent macrophage phagocytosis of Candida albicans (CAP), percent C. albicans killed by macrophages (CAK), percent major histocompatibility complex (MHC)-class II antigen expression, and antigen presentation. Macrophages isolated on postoperative day 1 were also cocultured with 100 units/10(6) cells/ml interferon-gamma (IFN-gamma). Laparotomy significantly impaired microbicidal activity (O2-, percent CAP, and percent CAK) and antigen presentation on postoperative day 1. On postoperative day 3, O2- and antigen presentation were increased significantly (p less than 0.05) over control values, indicating a rebound phenomenon. Kupffer cell microbicidal function was unchanged on postoperative days 1 and 3. The initial immune impairment (PM phis: O2-, CAP, and CAK) was abrogated by IFN-gamma treatment. In immunosuppressed hosts after injury, administration of macrophage-activating factors such as IFN-gamma could be of therapeutic benefit. 相似文献
19.
C McKenzie BAppSc P Megaw BAppSc I Morgan PhD MK Boelen PhD 《Clinical & experimental ophthalmology》1997,25(4):79-81
Deprivation of form vision by the fitting of translucent occluders suppressed the diurnal cycling of enkephalinergic amacrine cells (the ENSLI amacrine cells), in the chicken. Daily periods of normal vision or enforcing temporal contrast using strobe lighting appeared to restore normal functioning of the ENSLI cells. These results suggest that the ENSLI cells are involved in retinal circuits that assess the quality of the visual image and control eye growth. 相似文献