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731.
Carlijn Lelieveld MSc Rosanne Leipzig MD PhD Licia K. Gaber‐Baylis BA Madhu Mazumdar PhD Stavros G. Memtsoudis MD PhD Nicole Zubizarreta MPH Jashvant Poeran MD PhD 《Journal of the American Geriatrics Society》2017,65(9):2094-2099
Discharge against medical advice (DAMA) is associated with greater risk of hospital readmission and higher morbidity, mortality, and costs, but with a rapidly increasing elderly inpatient population, there is a lack of national data on DAMA in this subgroup. The National Inpatient Sample (2003–2013 for trends, 2013 for multivariable analysis, n = 29,290,852) was used to describe trends in DAMA in elderly inpatients, to study diagnosis codes associated with admission, and to assess factors associated with DAMA using multivariable logistic regression. Odds ratios (ORs) and 95% confidence intervals (CIs) are reported for risk factors of interest. Although DAMA rates in individuals aged 65 and older were one fourth of those found in individuals aged 18 to 64, an increasing trend was found in both groups. From 2003 to 2013, rates increased in individuals aged 18 to 64 (from 1.44% to 1.78%) and in those aged 65 and older (from 0.37% to 0.42% (both P < .001). In both age groups, individuals admitted for mental illness had the highest risk of DAMA. Factors associated with higher adjusted odds of DAMA were generally similar between age groups, although risk of DAMA was higher in elderly adults than in those aged 18 to 64 for blacks (OR 1.65, 95% CI 1.49–1.82 vs OR 1.16, 95% CI 1.12–1.20), Hispanics (OR 1.58, 95% CI 1.41–1.77 vs OR 0.83, 95% CI 0.79–0.87), and those in the lowest income quartile (OR 1.57, 95% CI 1.43–1.72 vs OR 1.12, 95% CI 1.08–1.17), suggesting that race/ethnicity and poverty are more pronounced as risk factors for DAMA in elderly inpatients. 相似文献
732.
Teresa Salomone Paola Boni Carla Serra Antonello Maria Morselli-Labate Anna Licia Di Gioia Maurizio Romboli Aurelia Guariento 《Journal of gastrointestinal cancer》1996,20(3):197-203
Summary
Conclusion
In acute pancreatitis (AP), the peripheral blood analysis, including reticulocytes (RC) and RC fractions, and its relationship
to the changes of the levels of the soluble interleukin 2 receptor (sIL-2R) can provide useful information about the involvement
of the immunoinflammatory system in AP and can indicate the severity of the disease.
Background In the disease clinical assessment, we correlated the sIL-2R serum levels to the peripheral blood components (including RC
and RC fractions) to serum albumin and C-reactive protein (CPR) during AP.
Methods In 21 patients with AP, sIL-2R, the total and differential white blood cell (WBC) counts, red blood cell (RBC) counts, RC,
RC fractions, hemoglobin (Hb), hematocrit (Ht), platelets (PLT), albumin, and CRP were evaluated from the onset to the sixth
day of illness.
Results sIL-2R increased in all the patients. The increase was directly related to eosinophils, monocytes, and to middle-aged (MFR)
RC, and inversely related to neutrophils and the old (LFR) RC. MFR-RC were directly related to the total WBC count, esoninophils,
and basophils, and inversely related to Hb and albumin. LFR-RC behaved in the opposite manner. CRP increased in 16 patients;
this rise was directly related to WBC, RC, and MFR-RC, and inversely related to Hb, LFR-RC, and albumin. sIL-2R and CRP values
were not statistically interrelated, but when the CRP levels were higher, the increase in sIL-2R was greater and more sustained. 相似文献
733.
E. Ciccarone † A. Di Castelnuovo M. Salcuni‡ A. Siani§ A. Giacco¶ M. B. Donati G. De Gaetano F. Capani† L. Iacoviello 《Journal of thrombosis and haemostasis》2003,1(8):1744-1752
Summary. Background : The 'Mediterranean diet' is considered to exert protective effects on cardiovascular disease, although a wide range of dietary patterns exists among subjects living even in the same Mediterranean country. Objective : To investigate the association between specific dietary patterns and peripheral arterial disease (PAD) in Italian Type 2 diabetes patients. Design : From a cohort of 944 patients with Type 2 diabetes, 144 patients with PAD were selected, and matched for age and sex with 288 Type 2 diabetic control patients without macrovascular complications. A dietary score was elaborated from a semiquantitative food frequency questionnaire. The higher the final score, the healthier the eating habit. Results : In multivariate analysis, a higher score was independently associated with a significant reduction in PAD risk [odds ratio (OR) = 0.44; 95% confidence interval (CI) 0.24, 0.83]. Diabetes duration (OR > 15 years = 2.49; 95% CI 1.45, 4.25), hypertension (OR = 2.12; 95% CI 1.31, 3.45) and butter consumption (OR = 2.6; 95% CI 1.15, 3.68) were also significantly associated with PAD. The dietary score significantly improved the predictive value of models based on duration of diabetes and hypertension. (LSR = 2.19, DF = 7, P < 0.001). The effect of a high dietary score on the risk of PAD was independent of diabetes duration and hypertension. Conclusions : In Italian Type 2 diabetics, a higher dietary score has a protective role against PAD. The use of butter increases the risk of PAD even in patients regularly consuming olive oil. Dietary advice may be helpful for the prevention of PAD in diabetics even in populations traditionally accustomed to a Mediterranean dietary habit. 相似文献
734.
Alberto E. Turco Bernard Peissel Sandro Rossetti Angelo Selicorni Siranoush Manoukian Alberto Brusasco Gianluca Tadini Andrea Galimberti Beatrice Tassis Licia Turolla Romano Tenconi Pier Franco Pignatti 《American journal of medical genetics. Part A》1993,47(8):1225-1230
Amniocentesis and fetal skin biopsies were performed at 18 weeks of gestation in a fetus at risk autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive junctional epidermolysis bullosa (EBJ) with pyloric atresia. A previous son of the couple under investigation had disd at 3 months of EBJ. The mother of the propositus has ADPKD. Genetic linkage studies were carried out in 11 relatives (4 with ADPKD), and on fetal DNA obtained from cultured amniocytes, using 8 flanking DNA markers tightly linked to the PKD1 locus on chromosome 16p, and a DNA marker linked to another putative ADPKD locus on chromosome 2p. The linkage results indicated that the fetus had not inherited the ADPKD chromosome from the affected mother, with a diagnostic accuracy of >99%. Ultrastructural and immunohistochemical analyses of multiple fetal skin biopsies showed no EBJ-associated abnormalities. Thus, combining recent morphological and molecular diagnostic methods, we could show that the fetus was free from both diseases. After 40 weeks of gestation, a normal male infant was delivered. © 1993 Wiley-Liss, Inc. 相似文献
735.
Emanuela Napoleone Antonella CutroneFilomena Zurlo Augusto Di CastelnuovoMarco D’Imperio Lucia GiordanoAmalia De Curtis Licia IacovielloDomenico Rotilio Chiara CerlettiGiovanni de Gaetano Maria Benedetta DonatiRoberto Lorenzet 《Thrombosis research》2013
Aim
Numerous epidemiological studies suggest that exposure to flavonoid-rich fruits has beneficial influence on risk factors for cardiovascular disease. We investigated whether intake of orange juice (OJ) could affect whole blood (WB) procoagulant activity.Methods
17 healthy subjects (aged 31 ± 1.5 SEM 10 males) were randomized to receive, according to a cross-over design, either red or blond OJ, enriched or free of anthocyanins, respectively. After one week run-in period on a controlled diet, the subjects were randomly allocated to receive either type of OJ for 4 weeks, with a 4-week wash-out period. Venous blood was collected on citrate before and at the end of each treatment period. WB was incubated with or without an inflammatory stimulus (tumor necrosis factor-α or bacterial endotoxin LPS). Procoagulant activity was evaluated by a one-stage clotting assay. Tissue factor (TF) and TF pathway inhibitor (TFPI) were measured in plasma by ELISA.Results
Intake of either type of OJ caused a prolongation of unstimulated and stimulated WB clotting times, without any difference between the two treatments. Intake of OJ did not modify TF levels. On the contrary, an increase in circulating TFPI antigen was detected following either treatment.Conclusions
Orange juice intake by healthy volunteers decreases procoagulant activity, possibly through mechanisms independent of its anthocyanin content. 相似文献736.
Brian M. Iacoviello Gang Wu Rany Abend James W. Murrough Adriana Feder Eyal Fruchter Yoav Levinstein Ilan Wald Christopher R. Bailey Daniel S. Pine Alexander Neumeister Yair Bar‐Haim Dennis S. Charney 《Journal of traumatic stress》2014,27(2):232-239
Cognitive theories implicate information‐processing biases in the etiology of anxiety disorders. Results of attention‐bias studies in posttraumatic stress disorder (PTSD) have been inconsistent, suggesting biases towards and away from threat. Within‐subject variability of attention biases in posttraumatic patients may be a useful marker for attentional control impairment and the development of posttrauma symptoms. This study reports 2 experiments investigating threat‐related attention biases, mood and anxiety symptoms, and attention‐bias variability following trauma. Experiment 1 included 3 groups in a cross‐sectional design: (a) PTSD, (b) trauma‐exposed without PTSD, and (c) healthy controls with no trauma or Axis I diagnoses. Greater attention‐bias variability was found in the PTSD group compared to the other 2 groups ; attention‐bias variability was significantly and positively correlated (r = .37) with PTSD symptoms. Experiment 2 evaluated combat‐exposed and nonexposed soldiers before and during deployment. Attention‐bias variability did not differentiate groups before deployment, but did differentiate groups during deployment ; increased variability was observed in groups with acute posttraumatic stress symptoms and acute depression symptoms only. Attention‐bias variability could be a useful marker for attentional impairment related to threat cues associated with mood and anxiety symptoms after trauma exposure. 相似文献
737.
Paola?Caroli Israel?Sandler Federica?Matteucci Ugo?De?Giorgi Licia?Uccelli Monica?Celli Flavia?Foca Domenico?Barone Antonino?Romeo Anna?Sarnelli Giovanni?PaganelliEmail author 《European journal of nuclear medicine and molecular imaging》2018,45(12):2035-2044
Purpose
We studied the usefulness of 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for detecting relapse in a prospective series of patients with biochemical recurrence (BCR) of prostate cancer (PCa) after radical treatment.Methods
Patients with BCR of PCa after radical surgery and/or radiotherapy with or without androgen-deprivation therapy were included in the study. 68Ga-PSMA PET/CT scans performed from the top of the head to the mid-thigh 60 min after intravenous injection of 150?±?50 MBq of 68Ga-PSMA were interpreted by two nuclear medicine physicians. The results were correlated with prostate-specific antigen (PSA) levels at the time of the scan (PSApet), PSA doubling time, Gleason score, tumour stage, postsurgery tumour residue, time from primary therapy to BCR, and patient age. When available, 68Ga-PSMA PET/CT scans were compared with negative 18F-choline PET/CT scans routinely performed up to 1 month previously.Results
From November 2015 to October 2017, 314 PCa patients with BCR were evaluated. Their median age was 70 years (range 44–92 years) and their median PSApet was 0.83 ng/ml (range 0.003–80.0 ng/ml). 68Ga-PSMA PET/CT was positive (one or more suspected PCa lesions detected) in 197 patients (62.7%). Lesions limited to the pelvis, i.e. the prostate/prostate bed and/or pelvic lymph nodes (LNs), were detected in 117 patients (59.4%). At least one distant lesion (LNs, bone, other organs, separately or combined with local lesions) was detected in 80 patients (40.6%). PSApet was higher in PET-positive than in PET-negative patients (P?<?0.0001). Of 88 patients negative on choline PET/CT scans, 59 (67%) were positive on 68Ga-PSMA PET/CT.Conclusion
We confirmed the value of 68Ga-PSMA PET/CT in restaging PCa patients with BCR, highlighting its superior performance and safety compared with choline PET/CT. Higher PSApet was associated with a higher relapse detection rate.738.
Jancineide Oliveira de Carvalho Francilio de Carvalho Oliveira Sérgio Antonio Pereira Freitas Liana Martha Soares Rita de Cássia Barros Lima Licia de Sousa Gonçalves Thomas Jay Webster Fernanda Roberta Marciano Anderson Oliveira Lobo 《Current osteoporosis reports》2018,16(5):626-634
Purpose of Review
To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs).Recent Findings
The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity.Summary
Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.739.
Marchesi F Sarli L Percalli L Sansebastiano GE Veronesi L Di Mauro D Porrini C Ferro M Roncoroni L 《World journal of surgery》2007,31(8):1658-1664
Background The aim of the study was to evaluate the effectiveness of subtotal colectomy with cecorectal anastomosis (SCCA) in the treatment
of slow-transit constipation, not just in terms of symptom resolution but also the overall impact on patients’ quality of
life.
Methods Between 1991 and 2005, 43 patients underwent SCCA at our institution, 22 for slow-transit constipation (STC) and 21 for other
types of colic diffuse disease (non-slow-transit constipation: NSTC), the latter being considered controls. A total of 29
patients (17 affected by STC) were administered a 50-item telephonic questionnaire, including the Gastrointestinal Quality
of Life Index (GIQLI), the Wexner constipation and incontinence scale (WC, WI), and individual willingness to repeat the procedure.
Questionnaire data and other parameters such as age, sex, length of follow-up, complications, and length of hospital stay
were analyzed and compared, in order to evaluate possible correlations between the parameters and their related impact on
quality of life, procedural effectiveness in terms of symptomatic regression, qualitative differences related to pathology
(constipation versus non-constipation), and surgical approach (laparotomy versus video-laparo-assisted procedure).
Results There were no procedure-related deaths in this series (mortality: 0%); however, we found two complications in the STC group
(9.1%), one requiring reoperation. The GIQLI mean score for the STC group was 115.5 ± 20.5 (mean score for healthy people
125.8 ± 13), and the WC mean score passed from a preoperative value of 20.3 to a postoperative value of 2.6. Regression analysis
revealed a significant correlation between GIQLI and urgency and abdominal pain, and abdominal pain correlated significantly
with pathology (STC). A high number of patients (88.2% in STC) expressed a willingness to repeat the procedure given the same
preoperative conditions.
Conclusions Comparing our results to those of the most homogeneous literature data, SCCA does not appear to be inferior to subtotal colectomy
with ileorectal anastomosis (IRA) in terms of therapeutic effectiveness, postoperative mortality and morbidity, or overall
impact on quality of life. 相似文献
740.
Giovanni Di Nardo Cesare Cremon Annamaria Staiano Vincenzo Stanghellini Osvaldo Borrelli Caterina Strisciuglio Claudio Romano Saverio Mallardo Elena Scarpato Giovanni Marasco Silvia Salvatore Letizia Zenzeri Enrico Felici Licia Pensabene Simona Sestito Ruggiero Francavilla Paolo Quitadamo Mariella Baldassarre Valentina Giorgio Renato Tambucci Chiara Ziparo Pasquale Parisi Maria Raffaella Barbaro Giovanni Barbara Neurogastroenterology Study Group of the Italian Society of Pediatric Gastroenterology Hepatology Nutrition 《Neurogastroenterology and motility》2023,35(3):e14365