全文获取类型
收费全文 | 36917篇 |
免费 | 3562篇 |
国内免费 | 2567篇 |
专业分类
耳鼻咽喉 | 336篇 |
儿科学 | 450篇 |
妇产科学 | 624篇 |
基础医学 | 4108篇 |
口腔科学 | 861篇 |
临床医学 | 4734篇 |
内科学 | 5194篇 |
皮肤病学 | 435篇 |
神经病学 | 1685篇 |
特种医学 | 1154篇 |
外国民族医学 | 17篇 |
外科学 | 3925篇 |
综合类 | 6580篇 |
现状与发展 | 3篇 |
一般理论 | 12篇 |
预防医学 | 2545篇 |
眼科学 | 1023篇 |
药学 | 4012篇 |
38篇 | |
中国医学 | 2186篇 |
肿瘤学 | 3124篇 |
出版年
2024年 | 147篇 |
2023年 | 619篇 |
2022年 | 1484篇 |
2021年 | 1745篇 |
2020年 | 1409篇 |
2019年 | 1227篇 |
2018年 | 1313篇 |
2017年 | 1137篇 |
2016年 | 1041篇 |
2015年 | 1663篇 |
2014年 | 2000篇 |
2013年 | 2013篇 |
2012年 | 2910篇 |
2011年 | 3079篇 |
2010年 | 2070篇 |
2009年 | 1729篇 |
2008年 | 2120篇 |
2007年 | 2025篇 |
2006年 | 1973篇 |
2005年 | 1874篇 |
2004年 | 1373篇 |
2003年 | 1393篇 |
2002年 | 1144篇 |
2001年 | 921篇 |
2000年 | 803篇 |
1999年 | 787篇 |
1998年 | 485篇 |
1997年 | 446篇 |
1996年 | 331篇 |
1995年 | 283篇 |
1994年 | 256篇 |
1993年 | 164篇 |
1992年 | 189篇 |
1991年 | 148篇 |
1990年 | 125篇 |
1989年 | 84篇 |
1988年 | 121篇 |
1987年 | 113篇 |
1986年 | 64篇 |
1985年 | 66篇 |
1984年 | 24篇 |
1983年 | 25篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 8篇 |
1979年 | 29篇 |
1978年 | 9篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1972年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
肺冲击伤对大鼠学习、记忆能力的影响及其机制 总被引:2,自引:0,他引:2
目的:探讨胸部局部冲击伤后大鼠神经行为功能改变,及肺冲击伤对中枢神经系统的影响。方法:致伤前,动物均在一计算机控制的双向穿梭箱内连续训练6d,每天 训练20次,以获得主动回避反射,在最后2d的训练中,AAR≥80%的大鼠被选用于冲击伤实验。采用BST-Ⅲ生物激波管致大鼠单纯肺冲击伤。脑组织内NO^-2/NO^-3,cGMP含量分别采用比色测定试剂盒和酶免疫测定试剂盒进行测定。 相似文献
992.
咪唑安定配伍不同药物对辅助硬膜外麻醉的临床效果 总被引:13,自引:0,他引:13
目的 探讨咪唑安定与芬太尼、氟哌啶及氟哌合剂(氟哌啶与哌替啶 )配伍作为硬膜外辅助用药镇静、镇痛及预防术中不良反应的效果 .方法 ASA II~ III行择期腹部手术患者 80例 ,按辅助用药不同随机分为 4组 (n=2 0 ) :氟哌合剂组 (DP)、咪芬 (MF)、咪哌 (MP)合剂组及咪唑安定与氟哌合剂联合用药组 (MDP) .术前了解患者对镇静的要求 ,于硬膜外麻醉首剂量 5~ 10 m in后静脉给药 ,术中观察并记录给药后 10 m in内的 BP,HR和 Sp O2 变化 ,患者镇静程度 ,不良反应发生率 ,并于术后随访患者对术中情况有无遗忘及对麻醉效果的评价 .结果 6 9%患者对术中镇静有明确要求 ;4组辅助用药对循环呼吸的干扰无差异 .达到 Ramsay 4级镇静所需时间 MF:(1.5± 1.0 ) min,MP:(1.7± 1.1) min,MDP:(3.5± 2 .0 ) min、明显短于 DP组 :(5 .8± 2 .8) min(P<0 .0 5 ) ;而 MDP组维持 4级以上镇静的作用时间是 (115 .7± 16 .8) min显著长于其他 3组 [MP:(80 .0± 32 .1) min;DP:(6 8.0± 4 9.5 ) min;MF:(5 6 .4± 19.1) min](P<0 .0 5 ) ;伍用咪唑安定的 3组患者产生遗忘作用高于 DP组 ,且患者的满意度相对较高 (P<0 .0 5 ) ,但各组术中牵拉反应发生率无差异 ,MP与 MDP组舌后坠发生率较高 (P<0 .0 5 ) .结论 硬膜外麻醉时咪 相似文献
993.
994.
目的:观察关节镜辅助下取自体掌长肌腱解剖重建远端桡尺韧带治疗慢性下尺桡关节不稳的临床疗效。方法对7例保守治疗无效的慢性下尺桡关节不稳患者,腕关节探查明确诊断,然后取自体掌长肌腱解剖重建远端桡尺韧带;平均随访12个月,记录患者手术前后的握力、腕关节活动度;采用视觉模拟评分(VAS)评估腕关节的疼痛状况,利用MMWS评分和DASH评分评估腕关节的功能状态。结果在腕关节活动时VAS评分从术前的(7±2)分恢复至术后的(3±3)分,MMWS评分为术前(50±9)分,术后(83±11)分,DASH评分从术前(37±15)分提升至术后(16±10)分,差异有统计学意义;握力术前为84.5±16.0,术后93.4±11.0,差异有统计学意义。腕关节屈伸活动度,术前为93.5%±6.0%,术后为96.4%±3.0%,旋前旋后活动度术前为92.6%±7.0%,术后为97.2%±5.0%,虽有增加,但差异没有统计学意义。结论在关节镜辅助下解剖重建远端桡尺韧带是治疗慢性下尺桡关节不稳的有效方法,短期随访效果满意。 相似文献
995.
996.
Junyu He Peiji Dai Liyi Liu Yanqing Yang Xibo Liu Yanbing Li Zhihong Liao 《Journal of Diabetes》2022,14(3):192
BackgroundDiabetes mellitus was a chronic low‐grade inflammatory disease and had increased circulating inflammatory cytokines and acute phase proteins. We aimed to identify the changes of inflammatory cytokines in newly diagnosed type 2 diabetic patients after short‐term intensive insulin therapy using continuous subcutaneous insulin infusion (CSII).MethodsThirty‐three newly diagnosed type 2 diabetic patients were enrolled between September 2020 to December 2020. Expression of 40 inflammatory cytokines of the patients were tested with RayBiotech antibody array before and after 1 week of intensive insulin therapy of CSII. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was carried out to explore the signaling pathway involved in the therapy.ResultsFive inflammatory cytokines were downregulated significantly after 1 week of CSII therapy. They were interleukin‐6 receptor (IL‐6R), regulated upon activation normal T‐cell expressed and secreted (RANTES), intercellular adhesion molecule‐1 (ICAM‐1), tissue inhibitor of metalloproteinase‐1 (TIMP‐1), and platelet‐derived growth factor type BB (PDGF‐BB) (p < 0.05 and foldchange <0.83). Among patients with baseline glycated hemoglobin (HbA1c) < 10%, three proinflammatory cytokines were decreased significantly after therapy: IL‐6R, RANTES, and ICAM‐1. As for the patients with baseline HbA1c ≥ 10%, eight inflammatory cytokines were inhibited significantly after the treatment, including ICAM‐1, IL‐6R, RANTES, TIMP‐1, TIMP‐2, macrophage inflammatory protein‐1 beta (MIP‐1β), PDGF‐BB, and tumor necrosis factor receptor type II (TNF RII). No matter which subgroup of baseline HbA1c level was considered, the decreased cytokines after CSII therapy were significantly involved in TNF signaling pathway. Nuclear factor‐kappa B (NF‐κB) signaling pathway was mainly enriched in patients with baseline HbA1c ≥ 10%.ConclusionsA panel of 40 inflammatory cytokines, measured by protein microarray, were evaluated for 1 week of CSII treatment in newly diagnosed type 2 diabetic patients. After treatment, many proinflammatory cytokines decreased. In the higher baseline HbA1c subgroup, more proinflammatory cytokines improved. No matter which subgroup of HbA1c level was considered, IL‐6R, RANTES, and ICAM‐1, which were involved in TNF signaling pathway, decreased significantly after CSII therapy. This was the first report showing that the cytokines of IL‐6R, TIMP‐2, PDGF‐BB, and TNF RII decreased after the CSII therapy. 相似文献
997.
目的 探讨小切口经腹膜外前路腰椎椎间融合术(anterior lumbar interbody fusion,ALIF)治疗复发性腰椎间盘突出症的疗效。方法 2001年2月至2012年2月应用小切口经腹膜外ALIF手术治疗复发性腰椎间盘突出症患者20例,男8例,女12例;年龄44~68岁,平均(53.1±5.9)岁。术中均采用SynFrame拉钩系统及SynFix-LR腰椎前路椎间融合器。统计术中出血量、术后48 h引流量、手术时间及住院天数。于术后2天、3、6、12个月进行随访,采用Oswestry功能障碍指数(Oswestry disability index,ODI)和疼痛视觉模拟评分(visual analogue scale,VAS)对手术疗效进行评估。结果 所有患者均获得随访,随访时间12~110个月,平均(45.6±29.6)个月。术后疼痛VAS评分与ODI值均较术前明显下降,差异有统计学意义(P<0.05),术后2天、3个月、6个月、12个月比较差异无统计学意义(P>0.05)。疼痛VAS评分由术前平均(7.7±0.7)分(5~8分)降至术后12个月平均(1.7±0.9)分(0~3分),ODI值由术前平均80.6%±3.9%(69%~85%)降至术后12个月6.6%±1.3%(5%~11%)。术中出血量90~220 ml,平均(126.0±40.3) ml;术后48 h引流量35~63 ml,平均(47.5±7.6) ml;住院天数4~11 d,平均(6.7±1.8) d。术后6个月骨性融合。随访期间融合器位置及形态正常,内固定无断裂及滑脱。结论 应用小切口经腹膜外ALIF手术治疗复发性腰椎间盘突出症,创伤小,能够缓解患者症状及改善功能,脊柱融合率高,手术并发症少,近中期疗效满意。 相似文献
998.
Liang Wang Nan Dai Dingrong Chen Airui Jiang Guobin Liao Chaoqiang Fan Xin Yang Xue Peng Xubiao Nie Hui Lin En Liu Xi Liu Xinwei Diao Jianying Bai 《American journal of cancer research》2022,12(4):1855
Little is known about esophageal high-grade intraepithelial neoplasia dominated by cytological atypia (HGINc). We aimed to elucidate the endoscopic features of HGINc compared with esophageal high-grade intraepithelial neoplasia dominated by architectural atypia (HGINa). All patients pathologically diagnosed as esophageal high-grade intraepithelial neoplasia after endoscopic submucosal dissection at our center between January 2018 and December 2019 were included in this study. According to the pathological diagnosis, the patients were divided into two groups: HGINa group and HGINc group. Basic characteristics and endoscopic information were collected in detail. Data were analyzed statistically. Binary logistic regression was performed and a predictive model for HGINc was established. Then we evaluated its predictive value and built a nomogram for clinical application. A total of 175 patients were included in this study (126 with HGINa and 49 with HGINc). Among 228 lesions found in all patients, there were 148 HGINa and 80 HGINc. The independent relevant factors for HGINc were tobacco and alcohol usage, color, and gross type. To predict risk of HGINc, a three-factor model (TFM) was established with a highest area under curve (AUC) as 0.869 (95% CI, 0.852, 0.939). When the cut-off value was set as 0.3569184, the diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for HGINc was 81.14%, 88.75%, 77.03%, 67.62%, and 92.68%, respectively. HGINc differs greatly in endoscopic features from HGINa in our study. It’s important to reduce misdiagnosis that our model was established with good predictive value for clinical application. 相似文献
999.
肝癌组织中TIMP-1和TIMP-2的表达意义 总被引:6,自引:1,他引:6
目的 了解TIMP-1和TIMP-2在肝癌组织中的表达状态,探讨TIMP-1和TIMP-2在肝癌组织生长、侵润及转移中所起的作用。方法 以抗TIMP-1和TIMP-2单克隆抗体(mAb)为试剂,采用免疫组织化学法检测原发性肝癌、肝高分化腺癌的肝组织中TIMP-1和TIMP-2的表达,并与10例正常肝组织做对照。结果 10例原发性肝癌患的肝组织中TIMP-1和TIMP-2蛋白表达的阳性率为100%,在癌组织及非癌组织中均有表达。癌组织中的TIMP-1和TIMP-2蛋白表达的强度比较为6例高于、4例低于周围的非癌组织(慢性肝炎及肝硬化组织),癌组织中TIMP-1和TIMP-2蛋白的表达呈散在性分布,但TIMP-1比TIMP-2表达强。9例肝高分化腺癌的腺癌组织中无TIMP-1和TIMP-2相关抗原的表达,但癌周组织的肝细胞有3例TIMP-1和TIMP-2蛋白表达为阳性。10例正常肝组织中TIMP-1和TIMP-2蛋白表达均为阴性。结论 TIMP-1和TIMP-2存在于原发性肝癌的癌组织中,其表达的部位与强度可能与癌的生长、浸润及转移有关。 相似文献
1000.