全文获取类型
收费全文 | 1077336篇 |
免费 | 77005篇 |
国内免费 | 2533篇 |
专业分类
耳鼻咽喉 | 15072篇 |
儿科学 | 27141篇 |
妇产科学 | 26577篇 |
基础医学 | 154902篇 |
口腔科学 | 31355篇 |
临床医学 | 94481篇 |
内科学 | 210968篇 |
皮肤病学 | 23275篇 |
神经病学 | 83320篇 |
特种医学 | 44134篇 |
外国民族医学 | 79篇 |
外科学 | 171571篇 |
综合类 | 19880篇 |
现状与发展 | 6篇 |
一般理论 | 311篇 |
预防医学 | 70683篇 |
眼科学 | 25296篇 |
药学 | 85194篇 |
3篇 | |
中国医学 | 3664篇 |
肿瘤学 | 68962篇 |
出版年
2021年 | 10199篇 |
2019年 | 9320篇 |
2018年 | 13083篇 |
2017年 | 10048篇 |
2016年 | 11746篇 |
2015年 | 14225篇 |
2014年 | 18481篇 |
2013年 | 25437篇 |
2012年 | 36016篇 |
2011年 | 36624篇 |
2010年 | 21663篇 |
2009年 | 20011篇 |
2008年 | 33255篇 |
2007年 | 34265篇 |
2006年 | 34250篇 |
2005年 | 32827篇 |
2004年 | 31123篇 |
2003年 | 29301篇 |
2002年 | 28077篇 |
2001年 | 57980篇 |
2000年 | 59556篇 |
1999年 | 49412篇 |
1998年 | 11893篇 |
1997年 | 10333篇 |
1996年 | 10403篇 |
1995年 | 9683篇 |
1994年 | 8932篇 |
1993年 | 8143篇 |
1992年 | 36669篇 |
1991年 | 35072篇 |
1990年 | 33744篇 |
1989年 | 32822篇 |
1988年 | 29883篇 |
1987年 | 29033篇 |
1986年 | 27055篇 |
1985年 | 25843篇 |
1984年 | 18336篇 |
1983年 | 15596篇 |
1982年 | 8130篇 |
1979年 | 16191篇 |
1978年 | 10937篇 |
1977年 | 9380篇 |
1976年 | 8152篇 |
1975年 | 8876篇 |
1974年 | 10765篇 |
1973年 | 10135篇 |
1972年 | 9623篇 |
1971年 | 9044篇 |
1970年 | 8628篇 |
1969年 | 8094篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
22.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study 下载免费PDF全文
23.
M.T. Leccia N. Auffret F. Poli J.‐P. Claudel S. Corvec B. Dreno 《Journal of the European Academy of Dermatology and Venereology》2015,29(8):1485-1492
Acne vulgaris (acne) is a chronic inflammatory disease of the sebaceous gland, characterized by follicular hyperkeratinization, excessive colonization by Propionibacterium acnes (P. acnes) as well as immune reactions and inflammation. Despite an armamentarium of topical treatments available including benzoyl peroxide, retinoids and azelaic acid, topical antibiotics in monotherapies, especially erythromycin and clindamycin, are still used in Europe to treat acne. This intensive use led to antimicrobial‐resistant P. acnes and staphylococci strains becoming one of the main health issues worldwide. This is an update on the current topical acne treatments available in Europe, their mechanism of action, their potential to induce antimicrobial resistance and their clinical efficacy and safety. 相似文献
24.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis 下载免费PDF全文
25.
Nancy C. Lee 《Public health reports (Washington, D.C. : 1974)》2015,130(2):121-Apr;130(2):121
26.
Lauren Tingey Britta Mullany Rachel Chambers Ranelda Hastings Angelita Lee Anthony Parker 《AIDS care》2015,27(9):1087-1097
Potential for widespread transmission of HIV/AIDS among American Indian (AI) adolescents exists, yet no evidence-based interventions (EBIs) have been adapted and evaluated with this population. Intensive psychoeducation may improve knowledge and decision-making which could potentially translate to reductions in HIV risk behaviors. A peer group randomized controlled comparison of an adapted EBI vs. control was delivered over an eight-day summer basketball camp in one reservation-based tribal community to adolescents ages 13–19. Outcome data were gathered immediately post-camp and at 6 and 12 months follow-up. Self-selected peer groups were randomized to intervention (n = 138) or control (n = 129) conditions for a total sample of 267 participants (56.2% female), mean age 15.1 years (SD = 1.7). Intervention participants had better condom use self-efficacy post-camp (Adjusted Mean Difference [AMD] = ?0.75, p < 0.005) and at 6 (AMD = ?0.44, p < 0.005) and 12 months (AMD = ?0.23, p < 0.05) follow-up. Intervention participants also had higher HIV prevention and transmission knowledge (post-camp: AMD = 0.07, p < 0.01; 6 months: AMD = 0.06, p < 0.01) were more likely to believe condoms prevent sexually transmitted infections (post-camp: RR = 1.41, p < 0.005; 6 months: RR = 1.34, p < 0.05), to talk with an adult about HIV/AIDS (post-camp: RR=1.78, p < 0.005; 6 months: RR = 1.14, p < 0.005), had higher partner negotiation efficacy related to substance use during sex (post-camp: AMD = 0.37, p < 0.01), and were more likely to intend to use a condom (post-camp: RR = 1.39, p < 0.01). The adapted intervention had short- and medium-term impacts on AI adolescent risk for HIV/AIDS, but attenuated at 12 months. Intervention delivery through a community-based camp is feasible and acceptable with strong retention. Additional study is needed to evaluate the adapted intervention's impact on sexual risk behaviors and if booster sessions and parent involvement translate to long-term impacts. 相似文献
27.
28.
29.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
30.