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101.
Aytekin FO Teke Z Aydin C Kabay B Yenisey C Sacar S Demir EM Tekin K 《American journal of surgery》2007,193(6):723-729
BACKGROUND: Tempol (Sigma-Aldrich, Steinheim, Germany) is a stable piperidine nitroxide of low molecular weight that permeates biologic membranes and scavenges superoxide anions in vitro. In recent animal studies, the delaying effect of intraperitoneal sepsis on the healing of colonic anastomoses has been shown. In this study we aimed to investigate the effects of Tempol on the healing of colonic anastomoses in the presence of polymicrobial sepsis. METHODS: Anastomosis of the left colon was performed on the day after cecal ligation and puncture (CLP) in 30 rats that were divided into 3 groups: sham-operated control (laparotomy and cecal mobilization, group I, n = 10), CLP (group II, n = 10), Tempol-treated group (30 mg/kg intravenously before the construction of colonic anastomosis, group III, n = 10). On postoperative day 6, all animals were killed and anastomotic bursting pressures were measured in vivo. Tissue samples were obtained for further investigation of anastomotic hydroxyproline (HP) contents, perianastomotic myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. RESULTS: There was a statistically significant increase in MPO activity and MDA levels in the CLP group (group II), along with a decrease in GSH levels, anastomotic HP contents, and bursting pressure values when compared with controls (group I). However, Tempol treatment led to a statistically significant increase in anastomotic bursting pressure values, tissue HP contents, and GSH levels, along with a decrease in MPO activity and MDA levels in group III (P < .05). CONCLUSIONS: This study showed that Tempol treatment significantly prevented the delaying effect of CLP-induced polymicrobial sepsis on anastomotic healing in the left colon. Further clinical studies are needed to clarify whether Tempol may be a useful therapeutic agent to increase the safety of the anastomosis during particular surgeries in which sepsis-induced organ injury occurs. 相似文献
102.
Koray AK Dogan S 《The Journal of thoracic and cardiovascular surgery》2007,133(5):1392-1392; author reply 1393
103.
Anthony N. van den Pol Koray Ozduman Guido Wollmann Winson S.C. Ho Ian Simon Yang Yao John K. Rose Prabhat Ghosh 《The Journal of comparative neurology》2009,516(6):456-481
Viruses have substantial value as vehicles for transporting transgenes into neurons. Each virus has its own set of attributes for addressing neuroscience‐related questions. Here we review some of the advantages and limitations of herpes, pseudorabies, rabies, adeno‐associated, lentivirus, and others to study the brain. We then explore a novel recombinant vesicular stomatitis virus (dG‐VSV) with the G‐gene deleted and transgenes engineered into the first position of the RNA genome, which replicates only in the first brain cell infected, as corroborated with ultrastructural analysis, eliminating spread of virus. Because of its ability to replicate rapidly and to express multiple mRNA copies and additional templates for more copies, reporter gene expression is amplified substantially, over 500‐fold in 6 hours, allowing detailed imaging of dendrites, dendritic spines, axons, and axon terminal fields within a few hours to a few days after inoculation. Green fluorescent protein (GFP) expression is first detected within 1 hour of inoculation. The virus generates a Golgi‐like appearance in all neurons or glia of regions of the brain tested. Whole‐cell patch‐clamp electrophysiology, calcium digital imaging with fura‐2, and time‐lapse digital imaging showed that neurons appeared physiologically normal after expressing viral transgenes. The virus has a wide range of species applicability, including mouse, rat, hamster, human, and Drosophila cells. By using dG‐VSV, we show efferent projections from the suprachiasmatic nucleus terminating in the periventricular region immediately dorsal to the nucleus. DG‐VSVs with genes coding for different color reporters allow multicolor visualization of neurons wherever applied. J. Comp. Neurol. 516:456–481, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
104.
Gul Basaran Nazım Serdar Turhal Devrim Cabuk Nevin Yurt Gul Yurtseven Mahmut Gumus Mehmet Teomete Faysal Dane Perran Fulden Yumuk 《Medical oncology (Northwood, London, England)》2011,28(2):409-415
Weight gain is a well-known and unwanted complication of adjuvant chemotherapy in breast cancer. We observed that the female
Turkish cancer patients frequently gain weight with adjuvant treatment of breast cancer and planned to examine the magnitude
of this problem in early breast cancer patients treated at our hospital. A total of 176 early breast cancer patients who received
their adjuvant systemic therapy in Marmara University Hospital between 2003 and 2007 are included in the study. We recorded
their weight before and after chemotherapy and also a year after chemotherapy to find out whether the change with weight is
transitory. We have also recorded demographic information, including the educational level, menopausal status, the type of
chemotherapy or hormonal treatment administered stage of disease, marital status, occupation and the underlying diseases to
analyze the relationship between change in weight and these parameters. Median age of patients was 53 and 72% of patients
were postmenopausal. Educational level was equally distributed for primary education (27%), high school (40%), and university
(33%). The majority of the patients (76%) was married, had two children (69%) and was housewife (60%). Family history of any
cancer was high (32%). Most of the patients had stage II cancer (56%), received anthracyclines+/− taxane based chemotherapy
(98%) and had no underlying disease (68%). The majority also did not smoke (73%) or drink alcohol (93%). A total of 67% and
72% patients gained weight upon completion and one year after completion of chemotherapy. Mean weight before the chemotherapy,
upon completion of chemotherapy and one year after completion of chemotherapy were 68.9 kg, 70.6 kg (P = 0.000) and 71.9 kg (P = 0.000) respectively. Mean body mass index was 27.1 at baseline, 27.8 upon completion of chemotherapy (P = 0.000) and 28.3 one year after completion of chemotherapy (P = 0.000). Age, menopausal status, multiparity and presence of comorbid diseases had statistically significant impact on weight
gain following adjuvant therapy in breast cancer patients (P = 0.000, P = 0.008, P = 0.015 and P = 0.017 respectively). This study shows that Turkish women with early breast cancer gain weight after adjuvant systemic therapy,
in line with European and American counterparts. This increase in weight is maintained at least one year after adjuvant therapy.
Given the adverse consequences of weight gain in terms of both breast cancer prognosis and general health, it is necessary
to inform patients about this change and to develop strategies for weight maintenance during and after systemic therapy. 相似文献
105.
Comparision of the effects of subtenon’s and subconjunctival anesthesia on retroorbital hemodynamics
Hasan Basri Cakmak Mehmet Coskun Huseyin Simavli Mehmet Gumus Ali Ipek Saban Simsek 《Central European Journal of Medicine》2009,4(1):84-90
The aim of the study was to compare retroorbital blood flow hemodynamics between subconjunctival and sub-Tenon’s anesthesia.
This was a prospective, blinded study and included 80 cases. Patients were monitored and treated in the First Ophthalmology
Clinic, Ataturk Training and Research Hospital, Turkey. Sub-Tenon’s anesthesia was performed in 42 cases, and subconjunctival
anesthesia was performed in 38 cases. Color Doppler imaging to measure ocular blood flow parameters was performed preoperatively
and 21 days after cataract operation in each case. Preoperative and postoperative values of resistivity and pulsatility indices
in the ophthalmic, central retinal, and short posterior ciliary arteries were compared. Postoperative mean blood flow velocity
measurements of ophthalmic artery were not statistically different between the subconjunctival anesthesia group and the sub-Tenon’s
anesthesia group (49.63 ± 14.00 vs. 45.85 ± 13.41; P=0.389). Postoperative RI values were higher in the Subtenon’s anesthesia group than in the subconjunctival anesthesia group,
but the difference between two groups was not statistically significant (0.81 ± 0.14 vs. 0.74 ± 0.08; P=0.079). The postoperative pulsatility index of the ophthalmic artery, RI of ophthalmic artery, pulsatility index of the central
retinal artery, RI of the central retinal artery, and pulsatility index of the posterior ciliary arteries were not significantly
different between the subconjunctival and sub-Tenon’s anesthesia groups. In conclusion, the study suggests that postoperative
retroorbital blood flow hemodynamics are the same following sub-Tenon’s and subconjunctival anesthesia. 相似文献
106.
107.
108.
109.
Teke Z Aytekin FO Kabay B Yenisey C Aydin C Tekin K Sacar M Ozden A 《World journal of surgery》2007,31(9):1835-1842
Background Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight thiol antioxidant and potent inhibitor of nuclear factor-κB (NF-κB)
activation. It has been shown to attenuate local harmful effects of ischemia/reperfusion (I/R) injury in many organs. In recent
animal studies, a delaying effect of remote organ I/R injury on the healing of colonic anastomoses has been demonstrated.
In this study we investigated whether PDTC prevents harmful systemic effects of superior mesenteric I/R on left colonic anastomosis
in rats.
Methods Anastomosis of the left colon was performed in 40 rats randomly allocated into the following four groups: (1) Sham-operated
group (group I, n = 10)—simultaneously with colonic anastomosis, the superior mesenteric artery and collateral branches divided from the celiac
axis and the inferior mesenteric artery were isolated but not occluded. (2) Sham+PDTC group (group II, n = 10)—identical to sham-operated rats except for the administration of PDTC (100 mg/kg IV bolus) 30 minutes prior to commencing
the experimental period. (3) I/R group (group III, n = 10)—60 minutes of intestinal I/R by superior mesenteric artery occlusion. (4) PDTC-treated group (group IV, n = 10)—PDTC 100 mg/kg before and after the I/R. On postoperative day 6, all animals were sacrificed, and anastomotic bursting
pressures were measured in vivo. Tissue samples were obtained for investigation of anastomotic hydroxyproline (HP) contents,
perianastomotic malondialdehyde (MDA) levels, myeloperoxidase activity (MPO), and glutathione (GSH) level.
Results There was a statistically significant decrease in anastomotic bursting pressure values, tissue HP content and GSH level, along
with an increase in MDA level and MPO activity in group III, when compared to groups I, II, and IV (p < 0.05). However, PDTC treatment led to a statistically significant increase in anastomotic bursting pressure values, tissue
HP content and GSH level, along with a decrease in MDA level and MPO activity in group IV (p < 0.05).
Conclusions This study showed that PDTC treatment significantly prevented the delaying effect of remote organ I/R injury on anastomotic
healing in the colon. Further clinical studies are needed to clarify whether PDTC may be a useful therapeutic agent for increasing
the safety of the anastomosis during particular operations where remote organ I/R injury occurs. 相似文献
110.
The concomitant presence of myeloproliferative disorders and the need for coronary artery bypass surgery is a surgical dilemma. Thrombosis and hemorrhage can cause difficult problems and might require different approaches during and after surgery. We report a patient who had idiopathic myelofibrosis and underwent a successful coronary artery bypass surgery. 相似文献