全文获取类型
收费全文 | 1925篇 |
免费 | 88篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 27篇 |
妇产科学 | 5篇 |
基础医学 | 188篇 |
口腔科学 | 59篇 |
临床医学 | 127篇 |
内科学 | 484篇 |
皮肤病学 | 21篇 |
神经病学 | 148篇 |
特种医学 | 100篇 |
外科学 | 305篇 |
综合类 | 6篇 |
预防医学 | 36篇 |
眼科学 | 99篇 |
药学 | 216篇 |
中国医学 | 4篇 |
肿瘤学 | 191篇 |
出版年
2023年 | 32篇 |
2022年 | 25篇 |
2021年 | 61篇 |
2020年 | 44篇 |
2019年 | 50篇 |
2018年 | 40篇 |
2017年 | 45篇 |
2016年 | 45篇 |
2015年 | 55篇 |
2014年 | 66篇 |
2013年 | 95篇 |
2012年 | 158篇 |
2011年 | 146篇 |
2010年 | 72篇 |
2009年 | 73篇 |
2008年 | 103篇 |
2007年 | 105篇 |
2006年 | 140篇 |
2005年 | 121篇 |
2004年 | 107篇 |
2003年 | 115篇 |
2002年 | 105篇 |
2001年 | 27篇 |
2000年 | 8篇 |
1999年 | 25篇 |
1998年 | 18篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 7篇 |
1994年 | 12篇 |
1993年 | 6篇 |
1992年 | 13篇 |
1991年 | 7篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 11篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1979年 | 3篇 |
1977年 | 7篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1910年 | 1篇 |
排序方式: 共有2026条查询结果,搜索用时 15 毫秒
31.
Tohru Tamaki Mitsuko Tanaka Masamichi Katori Makoto Osanai Mitsuo Yasuhara Jun-ichi Meguro Kazutaka Kukita Motoki Yonekawa Akio Kawamura 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》1998,2(4):308-310
Abstract: The barrier of ABO-incompatible kidney transplantation is the presence of anti-A and anti-B antibodies in the recipient's circulating blood. Double filtration plasmapheresis (DFPP) is usually used to eliminate those antibodies. We tried cryofiltration apheresis (CRYO) in 2 recipients. Patient 1 was a 45-year-old male with B, Rh(±). The titers of IgM anti-A antibody were only reduced from ×64 to ×32 by the end of 3 sessions of standard CRYO. Renal allografting was not performed. Case 2 was a 29-year-old male with B, Rh(+). CRYO was introduced for 3 sessions. The initial IgM and IgG titers were ×128 and negative, respectively. The standard CRYO system was modified by temperature, treated volume, and filter pore size. The IgM anti-A antibody titer was markedly reduced to ×2 after the final session of CRYO. The donor was a 56-year-old father with A, Rh(+). Tacrolimus, azathio-prine, methylprednisolone, and antilymphocyte globulin were used as the introductory immunosuppression therapy. 相似文献
32.
33.
34.
Shinpei Yoshimura Yasumasa Okamoto Keiichi Onoda Miki Matsunaga Go Okada Yoshihiko Kunisato Atsuo Yoshino Kazutaka Ueda Shin-ichi Suzuki Shigeto Yamawaki 《Social cognitive and affective neuroscience》2014,9(4):487-493
Cognitive behavioral therapy (CBT), an effective treatment for depression, targets self-referential processing of emotional stimuli. We examined the effects of CBT on brain functioning during self-referential processing in depressive patients using functional magnetic resonance imaging (fMRI). Depressive patients (n = 23) and healthy participants (n = 15) underwent fMRI scans during a self-referential task using emotional trait words. The depressive patients had fMRI scans before and after completing a total of 12 weekly sessions of group CBT for depression, whereas the healthy participants underwent fMRI scans 12 weeks apart with no intervention. Before undergoing CBT, the depressive patients showed hyperactivity in the medial prefrontal cortex (MPFC) during self-referential processing of negative words. Following CBT, MPFC and ventral anterior cingulate cortex (vACC) activity during self-referential processing among depressive patients was increased for positive stimuli, whereas it was decreased for negative stimuli. Improvements in depressive symptoms were negatively correlated with vACC activity during self-referential processing of negative stimuli. These results suggest that CBT-related improvements in depressive symptoms are associated with changes in MPFC and vACC activation during self-referential processing of emotional stimuli. 相似文献
35.
36.
37.
Yutaka Chuman Tomoyuki Sumizawa Yuji Takebayashi Kiyoshi Niwa Kazutaka Yamada Misako Haraguchi Tatsuhiko Furukawa Shin-ichi Akiyama Takashi Aikou 《International journal of cancer. Journal international du cancer》1996,66(2):274-279
MRP has been identified as another multidrug-resistance (MDR) gene and may be involved in an alternative MDR mechanism in some solid tumors. We investigated the expression of MRP mRNA in multidrug-resistant KB sublines (KB-8-5, KB-C2, C-A40 and C-A120), human non-small-cell lung carcinomas (NSCLC), gastric and colorectal carcinomas, and compared it with that in drug-sensitive human KB cells, MRP gene expression was elevated in 8 of 9 (89%) squamous-cell carcinomas of the lung. Furthermore, MRP expression in 4 squamous-cell carcinomas (L13, 18, 19 and 20) was more than 3.6 times higher than in KB-3-I cells, and the average MRP mRNA expression level of all squamous-cell carcinomas was significantly higher than that of adenocarcinoma of the lung and of colorectal and gastric carcinomas. These results suggested that the MRP is responsible, at least in part, for drug resistance in some squamous-cell carcinomas of the lung. © 1996 Wiley-Liss, Inc. 相似文献
38.
Haluk Tarik Kani Coskun Ozer Demirtas Caglayan Keklikkiran Ilkay Ergenc Shahin Mehdiyev Esra Akdeniz Yusuf Yilmaz 《The Turkish journal of gastroenterology》2021,32(8):661
Background: Metabolic syndrome (MS) is a condition that consists of several disorders, and the individual impact of these disorders on metabolic dysfunction-associated fatty liver disease (MAFLD) is still not clear in a combined diagnosis of MS. In this study, we aimed to investigate the effect of MS on advanced fibrosis in patients with MAFLD.Methods: We recruited the patients from our gastroenterology out-patient clinic who were being followed up for MAFLD. MAFLD was diagnosed with liver biopsy in all patients. The frequency of MS and other metabolic parameters were also compared between groups with advanced fibrosis and groups in which fibrosis was not as advanced.Results: In total, we enrolled 424 biopsy-proven MAFLD patients to the study. In univariate analysis, individuals with greater age, body mass index (BMI), higher aspartate transaminase (AST), MS, impaired fasting glucose, hypertension, enlarged waist circumference (WC), diabetes mellitus (DM), and women had significantly increased risk for fibrosis. In multivariate analysis, it was found that DM, greater age, higher BMI, and increased AST were seen more commonly in MAFLD patients with advanced fibrosisConclusion: Greater age, a higher BMI, higher AST and a diagnosis of diabetes were more commonly associated with advanced fibrosis. However, DM was found to be the strongest predictive factor of advanced fibrosis in our cohort (OR: 2.495). Multivariate analyses did not indicate a significantly common occurrence of MS in the advanced fibrosis group, despite its important role in MAFLD pathophysiology. 相似文献
39.
Kumi O. Kuroda Yuko Shiraishi Kazutaka Shinozuka 《Psychiatry and clinical neurosciences》2020,74(10):516-526
Behaviors comparable to human child maltreatment are observed widely among mammals, in which parental care is mandatory for offspring survival. This article first reviews the recent findings on the neurobiological mechanisms for nurturing (infant caregiving) behaviors in mammals. Then the major causes of attack/desertion toward infants (conspecific young) in nonhuman mammals are classified into five categories. Three of the categories are ‘adaptive’ in terms of reproductive fitness: (i) attack/desertion toward non‐offspring; (ii) attack/desertion toward biological offspring with low reproductive value; and (iii) attack/desertion toward biological offspring under unfavorable environments. The other two are nonadaptive failures of nurturing motivation, induced by: (iv) caregivers’ inexperience; or (v) dysfunction in caregivers’ brain mechanisms required for nurturing behavior. The proposed framework covering both adaptive and nonadaptive factors comprehensively classifies the varieties of mammalian infant maltreatment cases and will support the future development of tailored preventive measures for each human case. Also included are remarks that are relevant to interpretation of available animal data to humans: (1) any kind of child abuse/neglect is not justified in modern human societies, even if it is widely observed and regarded as adaptive in nonhuman animals from the viewpoint of evolutionary biology; (2) group‐level characteristics cannot be generalized to individuals; and (3) risk factors are neither deterministic nor irreversible. 相似文献
40.
Noriaki Yoshida Hiroaki Miyoshi Fumiko Arakawa Kazutaka Nakashima Keisuke Kawamoto Masao Seto Koichi Ohshima 《Hematological oncology》2020,38(5):673-679
Follicular lymphoma (FL) is a germinal center-derived B-cell lymphoma that is known to proliferate in the intrafollicular region. However, lymphoma cells can be identified in the extrafollicular regions, which are related to disease dissemination. We purified the intrafollicular and extrafollicular regions of FL cells by laser microdissection and conducted microarray analysis in order to characterize the gene expression profiles of FL cells from both regions. BCL2 and genes of germinal B-cell markers clearly separated intrafollicular and extrafollicular regions of reactive follicular hyperplasia, suggesting the adequacy of the current analysis. In FL cases, cytokine-related genes were significantly enriched in extrafollicular regions compared with those in the intrafollicular regions. In intrafollicular regions of FL, cell-cycle–related genes were enriched. We found that the FL cells in the extrafollicular region more strongly expressed IL3RA and CXCL12 than those of intrafollicular regions. The cytokines might be also derived from stroma cells in the extrafollicular regions, which may initiate activation and migration of the tumor cells to this region. Our results suggest that FL cell interaction with surrounding stroma cells plays an important role in the pathophysiology of FL and that such interactions should be a good target for therapy. 相似文献