全文获取类型
收费全文 | 682篇 |
免费 | 53篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 27篇 |
妇产科学 | 14篇 |
基础医学 | 102篇 |
口腔科学 | 11篇 |
临床医学 | 91篇 |
内科学 | 135篇 |
皮肤病学 | 22篇 |
神经病学 | 108篇 |
特种医学 | 15篇 |
外科学 | 36篇 |
预防医学 | 86篇 |
眼科学 | 9篇 |
药学 | 38篇 |
中国医学 | 2篇 |
肿瘤学 | 40篇 |
出版年
2024年 | 3篇 |
2023年 | 7篇 |
2022年 | 11篇 |
2021年 | 11篇 |
2020年 | 12篇 |
2019年 | 19篇 |
2018年 | 16篇 |
2017年 | 26篇 |
2016年 | 24篇 |
2015年 | 24篇 |
2014年 | 28篇 |
2013年 | 50篇 |
2012年 | 53篇 |
2011年 | 42篇 |
2010年 | 29篇 |
2009年 | 30篇 |
2008年 | 30篇 |
2007年 | 43篇 |
2006年 | 42篇 |
2005年 | 40篇 |
2004年 | 45篇 |
2003年 | 38篇 |
2002年 | 27篇 |
2001年 | 13篇 |
2000年 | 4篇 |
1999年 | 12篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1995年 | 6篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 4篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有738条查询结果,搜索用时 171 毫秒
11.
Metronomic therapy can increase quality of life during paediatric palliative cancer care,but careful patient selection is essential
下载免费PDF全文
![点击此处可从《Acta paediatrica (Oslo, Norway : 1992)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
12.
13.
14.
15.
Laura Pirkola Reijo Laatikainen Jussi Loponen Sanna-Maria Hongisto Markku Hillil? Anu Nuora Baoru Yang Kaisa M Linderborg Riitta Freese 《World journal of gastroenterology : WJG》2018,(11)
AIM To compare the effects of regular vs low-FODMAP rye bread on irritable bowel syndrome(IBS) symptoms and to study gastrointestinal conditions with Smart Pill?.METHODS Our aim was to evaluate if rye bread low in FODMAPs would cause reduced hydrogen excretion,lower intraluminal pressure,higher colonic p H,different transit times,and fewer IBS symptoms than regular rye bread.The study was a randomized,double-blind,controlled cross-over meal study.Female IBS patients(n = 7) ate study breads at three consecutive meals during one day.The diet was similar for both study periods except for the FODMAP content of the bread consumed during the study day.Intraluminal p H,transit time,and pressure were measured by Smart Pill,an indigestible motility capsule.RESULTS Hydrogen excretion(a marker of colonic fermentation) expressed as area under the curve(AUC)(0-630 min) was [median(range)] 6300(1785-10800) ppm?min for low-FODMAP rye bread and 10 635(4215-13080) ppm?min for regular bread(P = 0.028).Mean scores of gastrointestinal symptoms showed no statistically significant differences but suggested less flatulence after low-FODMAP bread consumption(P = 0.063).Intraluminal pressure correlated significantly with total symptom score after regular rye bread(ρ = 0.786,P = 0.036) and nearly significantly after lowFODMAP bread consumption(ρ = 0.75,P = 0.052).We found no differences in p H,pressure,or transit times between the breads.Gastric residence of Smart Pill was slower than expected.Smart Pill left the stomach in less than 5 h only during one measurement(out of 14 measurements in total) and therefore did not follow on par with the rye bread bolus.CONCLUSION Low-FODMAP rye bread reduced colonic fermentation vs regular rye bread.No difference was found in median values of intraluminal conditions of the gastrointestinal tract. 相似文献
16.
Maria Lagerstedt M.D. Kaisa Karvinen B.M. Minna Joki‐Erkkilä M.D. Riitta Huotari‐Orava M.D. Erna Snellman M.D. Satu‐Leena Laasanen M.D. 《Pediatric dermatology》2013,30(4):444-450
Childhood lichen sclerosus (LS) is a rare and often misdiagnosed inflammatory dermatitis with an unpredictable course. The complications of LS are architectural changes of the vulva; malignant transformation is possible. The objective of our study was to define the background and the long‐term course of childhood LS. A registery study identified 44 children with LS treated at Tampere University Hospital, Tampere, Finland, from 1982 to 2010. A questionnaire was sent to the identified patients and 15 responded. The clinical depiction of LS varied significantly. LS was diagnosed in only 16% of the patients at the referring unit. Autoimmune disorders were observed in 6 of the 44 patients. High prevalences of Turner's syndrome (2/44) and kidney disease (2/44) were noted. The majority of the patients were treated with topical corticosteroids. Eight developed architectural changes of the vulva. The questionnaire revealed that three of six patients who were asymptomatic at the end of the registery study follow‐up experienced a recurrence of symptoms. None of them were undergoing follow‐up. Nine of the 15 patients reported reduced quality of life. Childhood LS is a heterogeneous disease with a remarkable effect on quality of life. The misdiagnosis of childhood LS is common. The association between LS and autoimmune diseases should be noted. The high prevalence of Turner's syndrome raises questions regarding the influence of low estrogen levels on the development of LS. The prognosis cannot be predicted, so long‐term follow‐up is recommended. New tools for diagnosis and surveillance are needed. 相似文献
17.
Sirpa Loukovaara Erika Gucciardo Pauliina Repo Jouko Lohi Petri Salven Kaisa Lehti 《Case reports in ophthalmology》2015,6(2):228-238
PurposePathological vascular differentiation in retinal vein occlusion (RVO)-related neovessel formation remains poorly characterized. The role of intraocular lymphatic-like differentiation or endothelial progenitor cell activity has not been studied in this disease.MethodsVitrectomy was performed in an eye with hemi-RVO; the neovessel membrane located at the optic nerve head was removed and subjected to immunohistochemistry. Characterization of the neovascular tissue was performed using hematoxylin and eosin, α-smooth muscle actin, and the pan-endothelial cell (EC) adhesion molecule CD31. The expression of lymphatic EC markers was studied by lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), podoplanin (PDPN), and prospero-related homeobox protein 1 (Prox-1). Potential vascular stem/progenitor cells were identified by active cellular proliferation (Ki67) and expression of the stem cell marker CD117.ResultsThe specimen contained blood vessels lined by ECs and surrounded by pericytes. Immunoreactivity for LYVE-1 and Prox-1 was detected, with Prox-1 being more widely expressed in the active Ki67-positive lumen-lining cells. PDPN expression was instead found in the cells residing in the extravascular tissue. Expression of the stem cell markers CD117 and Ki67 suggested vascular endothelial progenitor cell activity.ConclusionsIntraocular lymphatic-like differentiation coupled with progenitor cell activation may be involved in the pathology of neovessel formation in ischemia-induced human hemi-RVO.Key Words: Hemi-retinal vein occlusion, Endothelial progenitor cell, Platelet endothelial cell adhesion molecule 1, Podoplanin, Prospero-related homeobox gene 1, Lymphatic endothelial cell, Lymphatic vessel endothelial hyaluronan receptor 1, Immunohistochemistry, Proliferative diabetic retinopathy, Vascular endothelial stem cell 相似文献
18.
19.
Wei Tseng Chen Tzung Lieh Yeh Venla Lehti Shu Hui Cheng Ching Lin Chu Kao Chin Chen 《Behavioral medicine (Washington, D.C.)》2013,39(2):49-53
Although the Dexamethasone Suppression Test (DST) plays an important role in psychosomatic research, confounding factors limit the sensitivity and specificity of the DST. The aim of this study was to investigate the relationship between the intensity of daily life stressors and DST results in healthy participants after controlling the confounding factors. The subjects of this study consisted of 75 healthy volunteers. The intensity of daily life events was assessed using the Taiwanese version of the Recent Life Change Questionnaire (RLCQ). Neuroticism was assessed using the Maudsley Personality Inventory (MPI). The Dexamethasone Suppression Test (DST) was also performed. The regression model showed that daily life events (RLCQ score) were correlated significantly with cortisol level on day 1 and D% only in women. This finding implies that daily life events should be considered as an independent variable in women in further studies when the DST is applied. 相似文献
20.
Kaisa M. Kemppainen Alexandria N. Ardissone Austin G. Davis-Richardson Jennie R. Fagen Kelsey A. Gano Luis G. León-Novelo Kendra Vehik George Casella Olli Simell Anette G. Ziegler Marian J. Rewers ?ke Lernmark William Hagopian Jin-Xiong She Jeffrey P. Krischer Beena Akolkar Desmond A. Schatz Mark A. Atkinson Eric W. Triplett the TEDDY Study Group 《Diabetes care》2015,38(2):329-332