全文获取类型
收费全文 | 2363899篇 |
免费 | 169816篇 |
国内免费 | 17882篇 |
专业分类
耳鼻咽喉 | 33514篇 |
儿科学 | 70782篇 |
妇产科学 | 64694篇 |
基础医学 | 328092篇 |
口腔科学 | 66645篇 |
临床医学 | 216844篇 |
内科学 | 444788篇 |
皮肤病学 | 51125篇 |
神经病学 | 180312篇 |
特种医学 | 92154篇 |
外国民族医学 | 691篇 |
外科学 | 351005篇 |
综合类 | 81535篇 |
现状与发展 | 54篇 |
一般理论 | 710篇 |
预防医学 | 167145篇 |
眼科学 | 57607篇 |
药学 | 187981篇 |
174篇 | |
中国医学 | 15703篇 |
肿瘤学 | 140042篇 |
出版年
2021年 | 24624篇 |
2019年 | 21489篇 |
2018年 | 28202篇 |
2017年 | 23123篇 |
2016年 | 24832篇 |
2015年 | 30270篇 |
2014年 | 40763篇 |
2013年 | 54231篇 |
2012年 | 73973篇 |
2011年 | 79002篇 |
2010年 | 47147篇 |
2009年 | 43177篇 |
2008年 | 69260篇 |
2007年 | 74097篇 |
2006年 | 74505篇 |
2005年 | 72143篇 |
2004年 | 66482篇 |
2003年 | 63435篇 |
2002年 | 61129篇 |
2001年 | 108673篇 |
2000年 | 111742篇 |
1999年 | 95307篇 |
1998年 | 27373篇 |
1997年 | 25026篇 |
1996年 | 23724篇 |
1995年 | 22292篇 |
1994年 | 20532篇 |
1992年 | 71119篇 |
1991年 | 68602篇 |
1990年 | 67217篇 |
1989年 | 65070篇 |
1988年 | 59937篇 |
1987年 | 58727篇 |
1986年 | 55872篇 |
1985年 | 52830篇 |
1984年 | 39207篇 |
1983年 | 33299篇 |
1982年 | 19452篇 |
1979年 | 36850篇 |
1978年 | 25863篇 |
1977年 | 22701篇 |
1976年 | 20381篇 |
1975年 | 23114篇 |
1974年 | 27301篇 |
1973年 | 26621篇 |
1972年 | 25324篇 |
1971年 | 23720篇 |
1970年 | 22244篇 |
1969年 | 21377篇 |
1968年 | 19723篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献75.
76.
77.
目的探讨乙肝孕妇血清标志物模式、HBV-DNA载量及肝功能三者之间的关系,为孕期乙肝病毒感染情况的监控和乙肝病毒母婴传播的预防提供参考。方法选取2019年1月-11月在我院产检的767例乙肝表面抗原阳性孕妇的乙肝血清标志物模式、肝功能指标的丙氨酸氨基转移酶(alamine aminotransferase,ALT)及HBVDNA载量进行研究,探讨三者间的关系。结果HBsAg、HBeAg、HBcAb阳性组孕妇HBV-DNA阳性率及病毒载量均高于其余两组(P<0.05);ALT升高程度与HBV-DNA载量具有一定相关性(r=0.255,χ^2=80.150,P=0.000);HBeAg阳性组和HBeAg阴性组间HBV-DNA阳性率、ALT异常率差异均有统计学意义。结论HBV-M、HBV-DNA与肝功能之间有一定的相关性,大三阳孕妇中高病毒载量比例高,应加强乙肝孕妇孕期各项指标的监测,必要时进行干预治疗。 相似文献
78.
79.
Recurrent Oral and Genital Ulcers in an Infant: Neonatal Presentation of Pediatric Behçet Disease 下载免费PDF全文
Emma F. Johnson M.D. Danielle M. Hawkins M.D. Laura K. Gifford M.D. Aimee C. Smidt M.D. 《Pediatric dermatology》2015,32(5):714-717
Behçet disease is a complex, multisystem disease characterized by recurrent oral and genital ulcerations. It rarely occurs in infants or children. Neonatal Behçet disease has been reported in infants whose ulcers resolve at or before 9 weeks of age. Few cases of neonatal Behçet disease persisting into childhood have previously been reported. We report the case of a 1‐month‐old infant who presented with severe recurrent genital ulcerations and at 6 months developed recurrent oral ulcerations. Her orogenital ulcerations continue to recur. Human leukocyte antigen testing revealed HLA‐B51 and B44 positivity. This is a case of pediatric Behçet disease in the neonatal period. Behçet disease should be considered in the differential diagnosis of recurrent genital and oral ulcerations in infants and children. 相似文献
80.
Jinju Wang Shuzhen Chen Wenfeng Zhang Yanfang Chen Ji C. Bihl 《CNS Neuroscience & Therapeutics》2020,26(12):1255
AimsWe previously showed that the protective effects of endothelial progenitor cells (EPCs)‐released exosomes (EPC‐EXs) on endothelium in diabetes. However, whether EPC‐EXs are protective in diabetic ischemic stroke is unknown. Here, we investigated the effects of EPC‐EXs on diabetic stroke mice and tested whether miR‐126 enriched EPC‐EXs (EPC‐EXsmiR126) have enhanced efficacy.MethodsThe db/db mice subjected to ischemic stroke were intravenously administrated with EPC‐EXs 2 hours after ischemic stroke. The infarct volume, cerebral microvascular density (MVD), cerebral blood flow (CBF), neurological function, angiogenesis and neurogenesis, and levels of cleaved caspase‐3, miR‐126, and VEGFR2 were measured on day 2 and 14.ResultsWe found that (a) injected EPC‐EXs merged with brain endothelial cells, neurons, astrocytes, and microglia in the peri‐infarct area; (b) EPC‐EXsmiR126 were more effective than EPC‐EXs in decreasing infarct size and increasing CBF and MVD, and in promoting angiogenesis and neurogenesis as well as neurological functional recovery; (c) These effects were accompanied with downregulated cleaved caspase‐3 on day 2 and vascular endothelial growth factor receptor 2 (VEGFR2) upregulation till day 14.ConclusionOur results indicate that enrichment of miR126 enhanced the therapeutic efficacy of EPC‐EXs on diabetic ischemic stroke by attenuating acute injury and promoting neurological function recovery. 相似文献