Application of validated mapping algorithms between generic PedsQL scores and utility values to individuals with sickle cell disease

Quality of Life Research - There is a paucity of empirically estimated health state utility (HSU) values to estimate health-related quality of life among individuals with sickle cell disease (SCD)....     

肌钙蛋白T试纸条预测充血性心力衰竭预后的意义

目的探讨肌钙蛋白T(TNT)试纸条在预测充血性心力衰竭(CHF)预后的价值。方法将CHF患者64例,按心功能分级分为轻、重度心功能不全组各34例,30例,用试纸条检测TNT,阳性判断临界值为0.1μg/L。结果轻、重度心功能不全组TNT阳性数各为0例,8例,有显著差异(P＜0.05);TNT阳性死亡率50%较阴性死亡率3.57%高(P＜0.05);TNT阳性住院日数(36.36±14.64)d较阴性住院数(23.82±11.29)d长(P＜0.05);TNT阳性预测患者死亡率特异性为93.01%,敏感性为66.67%。结论用试纸条测试TNT对CHF预后具有一定的预测价值。     

国人男性椎管的测量与观察

本文对广西出土的113例男性干燥椎骨的椎孔,进行了矢径、横径的测量和形态观察。椎孔的矢、横径在壮族(30例),汉族(57例)间无显著差异(P>0.05)。在C_(3～6)椎骨水平,推管的矢径和形态与脊髓的外形不一致,矢径于该处形成生理性狭窄,以C_4处为最小(12.92mm)。除C_1外,椎管的形态可分为4型:Ⅰ型圆型;Ⅱ型三角型;Ⅲ型过渡型;Ⅳ型不整型。 C_(1,2)椎管的形状为圆型,向下至C_6,通过半圆形逐步过渡到三角形(C_6占81.31％);再向下至T_6,三角形通过蛤形和多边形又逐渐过渡为圆形(T_6占84.76％);再向下至L_5,又通过蛤形逐渐过渡为三角型(L_5占99％)。从L_3至L_5,三角形椎孔有逐步通过钟形向三叶形过渡的趋势。三叶形腰椎管占5.02％。本文结果支持Eisenstein的观点,认为三叶形结构是一种普通的、非病理性的现象,与年龄增长、骨赘或椎孔狭窄无关,这或许是一种正常的发育性变异。     

应用彩色多普勒超声诊断结节性甲状腺病变

目的 探讨彩色多普勒超声鉴别诊断结节性甲状腺病变的意义。方法 回顾性分析病理或细胞学证实的结节性甲状腺病变74例二维超声和彩色多普勒超声（CDFI）表现。结果 结节性甲状腺肿、甲状腺腺瘤和腺癌超声和血流图像表现有一定规律性,定位准确,敏感性强。结论 彩色多普勒超声是诊断结节性甲状腺病变首选检查方法。     

RELATIONSHIP BETWEEN HUMAN PARVOVIRUS B19 INFECTION AND APLASTIC ANEMIA

Objective. To explore the relationship between human parvovirus B19 (HPV B19) infection and aplastic anemia (AA) and to investigate the role of HPV B19 in the occurrence of AA. Methods. The presence of HPV B19 DNA was detected in the peripheral blood samples of 60 patients with AA (children 38 and adults 22) by nested polymerase chain reaction (PCR) assay, and 30 healthy persons were selected as control. Results. Sixteen (26. 7 % ) of 60 AA cases were HPV B19 DNA positive, while all the samples in the control group were negative for HPV B19 (P = 0. 000914). Among the case group, the positive rates of HPV B19 DNA were21.4% (6 /28), 30.0% (3 / 10), 20.0% (1 /5) and 35.3% (6 / 17) in children acute AA (AAA), children chronic AA (CAA), adults AAA and adults CAA patients respectively, which were significant-ly higher than that in the control group, Furthermore, there was no remarkable difference between children AA and adults AA in the 16 HPV B19 DNA positive patients; neither was there between AAA and CAA. Conclusions. HPV B19 infection is not only correlated with the occurrence of children AAA and CAA, but also with adults AAA and CAA, and might be an important viral cause for AA in humans.     

半导体激光穴位照射的镇痛作用及其机制初探

目的　探讨半导体激光穴位照射镇痛效应及其镇痛的机制。方法　大鼠随机分成照射组、模拟照射组和纳洛酮预处理组。采用半导体激光照射大鼠“足三里”穴位 ,用电刺激鼠尾 -嘶叫法测定激光照射前后的痛阈。结果　照射后大鼠的痛阈明显提高 ,这种镇痛作用可被纳洛酮预处理所翻转。结论　半导体激光穴位照射产生镇痛效应机制可能与激光照射促进内源性阿片物质释放有关。     

γ—氨基丁酸治疗儿童植物神经性癫痫60例分析

目的　观察γ－ 氨基丁酸（ＧＡＢＡ） 治疗儿童植物神经性癫痫的临床疗效及其副作用。方法　详细记录６０ 例患儿治疗前３ 个月及口服ＧＡＢＡ（２５ ～３０ｍｇ／ｋｇ／ｄ）３ 个月后的发作频率及脑电图变化,并行统计学处理。结果　治疗后发作频率明显少于治疗前（ Ｐ＜ ００５） ,其中脑电图正常者更明显。结论　γ－ 氨基丁酸治疗儿童植物神经性癫痫疗效好,副作用小。     

大鼠脑局灶性预缺血对再次缺血的影响

目的研究不同时间单次缺血及重复缺血引起的脑组织病理变化。方法插线法阻塞大鼠大脑中动脉（ＭＣＡ）。单次缺血８、２８或９０ｍｉｎ,重复缺血８＋２８ｍｉｎ或２８＋９０ｍｉｎ。结果单次缺血组随缺血时间延长脑病变加重。８＋２８ｍｉｎ组ＭＣＡ供血区病变重于２８ｍｉｎ组;２８＋９０ｍｉｎ组ＭＣＡ供血区病变轻于９０ｍｉｎ组。结论不同时间的预缺血对再次缺血有导致积累性损伤或缺血耐受的双重效应。