全文获取类型
收费全文 | 89052篇 |
免费 | 7942篇 |
国内免费 | 6279篇 |
专业分类
耳鼻咽喉 | 677篇 |
儿科学 | 938篇 |
妇产科学 | 582篇 |
基础医学 | 8141篇 |
口腔科学 | 1535篇 |
临床医学 | 10949篇 |
内科学 | 11203篇 |
皮肤病学 | 708篇 |
神经病学 | 3603篇 |
特种医学 | 3693篇 |
外国民族医学 | 37篇 |
外科学 | 9662篇 |
综合类 | 20067篇 |
现状与发展 | 19篇 |
一般理论 | 4篇 |
预防医学 | 7339篇 |
眼科学 | 2061篇 |
药学 | 9662篇 |
88篇 | |
中国医学 | 5981篇 |
肿瘤学 | 6324篇 |
出版年
2024年 | 297篇 |
2023年 | 1099篇 |
2022年 | 2926篇 |
2021年 | 3606篇 |
2020年 | 2912篇 |
2019年 | 2303篇 |
2018年 | 2386篇 |
2017年 | 2571篇 |
2016年 | 2324篇 |
2015年 | 3786篇 |
2014年 | 4791篇 |
2013年 | 5047篇 |
2012年 | 7220篇 |
2011年 | 7704篇 |
2010年 | 5806篇 |
2009年 | 4991篇 |
2008年 | 5737篇 |
2007年 | 5593篇 |
2006年 | 5299篇 |
2005年 | 4565篇 |
2004年 | 3809篇 |
2003年 | 4098篇 |
2002年 | 3415篇 |
2001年 | 2640篇 |
2000年 | 2044篇 |
1999年 | 1411篇 |
1998年 | 840篇 |
1997年 | 784篇 |
1996年 | 563篇 |
1995年 | 500篇 |
1994年 | 487篇 |
1993年 | 260篇 |
1992年 | 267篇 |
1991年 | 259篇 |
1990年 | 193篇 |
1989年 | 173篇 |
1988年 | 128篇 |
1987年 | 134篇 |
1986年 | 93篇 |
1985年 | 58篇 |
1984年 | 53篇 |
1983年 | 32篇 |
1982年 | 30篇 |
1981年 | 16篇 |
1980年 | 7篇 |
1979年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
21.
A new micelle system formed from methoxy (polyethylene glycol)-b-poly (5-benzyloxy-trimethylene carbonate; MePEG-b-PBTMC 5000-b-4800) was investigated as a delivery system for the hydrophobic anti-cancer agent, ellipticine. The ellipticine was loaded into the MePEG-b-PBTMC micelles with a loading efficiency of 95% using a high-pressure extrusion technique. The ellipticine-loaded micelles have a spherical morphology and an average diameter of 96 nm. The anti-cancer activity of ellipticine was confirmed to be retained following formulation in the MePEG-b-PBTMC micelles. The extent of protein adsorption to the MePEG-b-PBTMC micelles was investigated by transmission electron microscopy, dynamic light scattering and gel filtration chromatography. Overall, the amount of protein both loosely and tightly associated with the micelles was found to be minimal and insignificant. The partitioning properties of ellipticine between an aqueous medium containing protein and the MePEG-b-PBTMC micelles were examined over a range of protein concentrations. Under physiologically relevant conditions, it was found that 61% of the drug remained within the micelle fraction while 39% was in the protein-containing aqueous phase. In addition, the in vitro drug release profile of ellipticine from the micelles was fit using a modified Higuchi model and found to be accelerated in the presence of protein. These studies demonstrate that although there are no significant interactions between micelle and protein, the properties of the micelle as a delivery vehicle may be strongly influenced by protein-drug interactions. 相似文献
22.
Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan 《Journal of gastrointestinal surgery》2008,12(8):1359-1363
We previously reported that lymphatic mapping using isosulfan blue can be used to identify sentinel nodes (SNs). This study
was undertaken to evaluate the feasibility of using the SN technique in treating early gastric cancer and to explore its usefulness
for minimal invasive surgery. Twenty-three patients with early gastric cancer who underwent SN biopsy were retrospectively
evaluated. Based on SN evaluation, individualized surgery was performed in five patients with T1N0M0 gastric cancer. When
pathological examination of frozen sections revealed metastasis in SNs, we performed a standard D2 gastrectomy. Laparoscopic
local resection was applied when the SN biopsy was negative. Our results showed that the success rate with SN biopsy in early
gastric cancer was 100%, as were the accuracy, sensitivity, and specificity. All five patients with early gastric cancer had
SNs negative for metastases both by frozen section and by postoperative pathology. Thus, all these patients underwent laparoscopic
local resection without extended lymphadenectomy. We conclude that SN biopsy is a useful tool to individualize the operative
procedure, and laparoscopic local resection can be safely performed using SN guidance in selected patients with early gastric
cancer. 相似文献
23.
螺旋CT三期扫描对肝纤维化诊断价值研究 总被引:5,自引:1,他引:4
目的探讨螺旋CT三期扫描对肝纤维化的诊断价值。方法对66例经肝穿刺活检病理证实的慢性乙型肝炎肝纤维化患者组和42例正常对照组进行螺旋CT三期增强扫描。根据纤维化程度分期进行影像资料和相关指标的统计分析。结果肝左叶增大,肝表面形态及肝实质密度的改变,脾脏增大,门静脉增宽和侧枝循环的建立等影像学改变,随着肝纤维化严重程度的加重而有统计学差异。本研究显示57例肝纤维化患者螺旋CT三期扫描诊断肝纤维化52例,敏感性91.2%,特异性77.8%。各期肝纤维化分期准确28例,准确率49.1%;准确判断轻度纤维化(S1、S2)或重度纤维化(S3、S4)44例,准确率77.2%,诊断早期肝硬化16例,准确率84.2%。结论螺旋CT三期扫描能判断肝纤维化的程度,而且是动态观察肝纤维化的病程演进和临床随访的有效手段。 相似文献
24.
点穴推拿治疗睡眠障碍68例 总被引:1,自引:0,他引:1
目的:观察点穴推拿治疗睡眠障碍的临床疗效。方法:采用点穴推拿治疗睡眠障碍68例不同病因引起的病症。结果:治愈30例,显效20例,有效10例,无效8例,总有效率88.24%。结论:点穴推拿对不同病因引起的睡眠障碍均有很好的疗效。 相似文献
25.
26.
LIU Haifeng LUO Zhenkun ZHANG Jian 《美国中华健康卫生杂志》2005,8(3):66-68
In this paper, the characteristics and regularities of acute ocular injuries by direct laser exposure are briefly reviewed, typical cases of ocular injuries from accidental laser exposure are reported, and laser occupational harm to the eye are discussed on the basis of epidemic investigation of personnel engaged in laser work. 相似文献
27.
本文介绍我院中心机房搬迁的同时升级HIS服务器的实施过程.研究了双机镜像备份环境下Oracle数据库升级的方法和数据迁移时应注意的问题.将Oracle数据库顺利的升级到Linux系统,并充分发挥双机镜像的优势,缩短停机时间. 相似文献
28.
目的 研究h-BMP-2基因转染骨髓间充质干细胞(BMSCs)在复合煅烧骨、β-TCP或直接植入裸鼠股部后的成骨能力。方法 通过影像学、组织学和形态计量学等方法,观察未经诱导、OS液诱导和h-BMP-2基因转染BMSCs在复合煅烧骨,或多孔β-TCP后植入裸鼠皮下,或直接制成细胞悬液注入,在4、8、12周诱导成骨和材料降解情况。结果 在裸鼠皮下,单纯生物陶瓷不能诱导成骨,而复合了未诱导、OS液诱导和h-BMP-2基因转染BMSCs的生物陶瓷均能成骨,成骨量为h-BMP-2基因转染组>OS液诱导组>未经诱导组(P<0.05),B-TCP可随骨长入而降解;注入裸鼠肌肉的OS液诱导的和h-BMP-2转染的BMSCs均能诱导成骨,而未经诱导MSCs则不能成骨。结论 复合人BMP基因转染BMSCs的β-TCP是一种理想的骨修复材料。 相似文献
29.
Mao-Sheng Ran Meng-Ze Xiang Jie Li Jian Huang Eric Yu-Hai Chen Cecilia Lai-Wan Chan Yeates Conwell 《Archives of Suicide Research》2007,11(1):119-127
The aim of this study was to compare the demographic and clinical characteristics of individuals with affective disorders who had attempted suicide at some time in their lives and those who had not made a suicide attempt. In a Chinese rural community, individuals with suicide attempt (N = 30) and those without suicide attempt (N = 166) were assessed with Present State Examination (PSE). Attempters had a significantly higher level of family economic status, higher rate of lifetime depressed mood and hopelessness, and delusions than nonattempters. The logistic regression models also indicated that depressed mood and hopelessness were the most important predictors of suicide attempts. No significant difference in treatment condition was found between attempters and non-attempters. Early identification and interventions focusing on reducing depressed mood, hopelessness, and controlling psychotic symptoms may be helpful in reducing the risk of suicide attempts among individuals with affective disorders residing in the community. 相似文献
30.
目的探讨小针刀辅助自体脂肪颗粒注射除去额部、眉间、鼻唇沟等部位皱纹及充填面部凹陷的效果。方法利用自制小针刀,离断真皮与其下方的"纤维粘连",然后用自体脂肪颗粒注射除皱和充填凹陷部位。结果本组共68例。修复面积最大约10cm×8cm,最小约1.5cm×0.5cm。随访45例,随访时间3~18个月,效果满意或基本满意。结论小针刀辅助自体脂肪移植具有操作简单、快捷、价廉、安全、无排异、不留瘢痕、术后恢复快等优点,患者易于接受,是除去额部、眉间、鼻唇沟等部位皱纹及填充面部凹陷的有效方法。 相似文献