收费全文 | 3428726篇 |
免费 | 275718篇 |
国内免费 | 21557篇 |
耳鼻咽喉 | 47616篇 |
儿科学 | 104020篇 |
妇产科学 | 91707篇 |
基础医学 | 475719篇 |
口腔科学 | 95665篇 |
临床医学 | 324203篇 |
内科学 | 660000篇 |
皮肤病学 | 70887篇 |
神经病学 | 282526篇 |
特种医学 | 134299篇 |
外国民族医学 | 1324篇 |
外科学 | 503584篇 |
综合类 | 112541篇 |
现状与发展 | 59篇 |
一般理论 | 1349篇 |
预防医学 | 274396篇 |
眼科学 | 82507篇 |
药学 | 257230篇 |
199篇 | |
中国医学 | 18679篇 |
肿瘤学 | 187491篇 |
2021年 | 34308篇 |
2019年 | 31793篇 |
2018年 | 41968篇 |
2017年 | 33116篇 |
2016年 | 35608篇 |
2015年 | 42875篇 |
2014年 | 59657篇 |
2013年 | 82403篇 |
2012年 | 112575篇 |
2011年 | 120049篇 |
2010年 | 70881篇 |
2009年 | 65990篇 |
2008年 | 107315篇 |
2007年 | 113211篇 |
2006年 | 114468篇 |
2005年 | 111867篇 |
2004年 | 103560篇 |
2003年 | 99594篇 |
2002年 | 96534篇 |
2001年 | 154233篇 |
2000年 | 159417篇 |
1999年 | 135501篇 |
1998年 | 41539篇 |
1997年 | 37992篇 |
1996年 | 37080篇 |
1995年 | 35476篇 |
1994年 | 32732篇 |
1993年 | 30037篇 |
1992年 | 104873篇 |
1991年 | 100729篇 |
1990年 | 96786篇 |
1989年 | 92906篇 |
1988年 | 86162篇 |
1987年 | 84678篇 |
1986年 | 79735篇 |
1985年 | 76070篇 |
1984年 | 58000篇 |
1983年 | 49389篇 |
1982年 | 30248篇 |
1979年 | 53548篇 |
1978年 | 37761篇 |
1977年 | 31673篇 |
1976年 | 29767篇 |
1975年 | 31024篇 |
1974年 | 38153篇 |
1973年 | 36454篇 |
1972年 | 34192篇 |
1971年 | 31446篇 |
1970年 | 29740篇 |
1969年 | 27674篇 |
Introduction
In the United States there has been a large increase in participation in lacrosse for both males and females. The purpose of this study was to analyze the number of head injuries, injury rates (calculated using the reported number of participants) and types of head injuries that are seen in emergency departments in the United States.Methods
We compared injuries between male and female lacrosse participants. This was a retrospective study using a publicly available database produced by the US Consumer Product Safety Commission and information about lacrosse participation from US Lacrosse.Results
A linear regression was performed and showed a positive correlation between number of head injuries to males and time from 2002 to 2010 (R2?=?0.823; p?=?0.001). While the number of injuries to the head in female lacrosse participants was not significant. There was a negative correlation between the number of head injuries to males from 2010 to 2016 (R2?=?0.800; p?=?0.007), but again, there was no significance for female injury count (R2?=?0.417; p?=?0.117). Other significant differences between head injuries in males and females included the mechanism of injury and the type of injury recorded.Conclusion
The most recent data from 2010 to 2016, suggest that both males and females have had a decrease in injury rate. However the total number of female head injuries is not significantly decreasing and as the sport continues to grow there will likely be more total head injuries and visits to the emergency department. 相似文献Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献Methods: Case report and the literature search of all English articles on delivery while on ECMO in patients with ARDS caused by influenza.
Results: A 25-year-old pregnant woman was initiated with ECMO due to severe ARDS caused by influenza A (H1N1) virus. When the patient had symptoms of colporrhagia and uterine contractions, the medical team decided to start labour induction while on ECMO. There were in total five case reports identified. Maternal oxygenation was improved after delivery and ECMO was successfully discontinued.
Conclusions: Maternal oxygenation was improved after delivery, which may be beneficial to reduce the duration of ECMO. Caesarean section (CS) may be the most used mode and labour induction could be another option. The procedure should be performed by an experienced ECMO team, cooperating with the obstetrician, anaesthesiologist, and ICU doctors. 相似文献