全文获取类型
收费全文 | 290篇 |
免费 | 18篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 4篇 |
妇产科学 | 17篇 |
基础医学 | 37篇 |
口腔科学 | 5篇 |
临床医学 | 25篇 |
内科学 | 65篇 |
皮肤病学 | 3篇 |
神经病学 | 18篇 |
特种医学 | 15篇 |
外科学 | 54篇 |
预防医学 | 25篇 |
眼科学 | 5篇 |
药学 | 15篇 |
中国医学 | 1篇 |
肿瘤学 | 16篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 16篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 11篇 |
2016年 | 9篇 |
2015年 | 8篇 |
2014年 | 19篇 |
2013年 | 11篇 |
2012年 | 25篇 |
2011年 | 14篇 |
2010年 | 13篇 |
2009年 | 12篇 |
2008年 | 14篇 |
2007年 | 22篇 |
2006年 | 32篇 |
2005年 | 13篇 |
2004年 | 14篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有308条查询结果,搜索用时 15 毫秒
61.
62.
Andreza Lúcia Menezes Mayara Peron Pereira Samyra Lopes Buzelle Maísa Pavani dos Santos Suélem Aparecida de França Amanda Martins Baviera Cláudia Marlise Balbinotti Andrade Maria Antonieta Rissato Garófalo Isis do Carmo Kettelhut Valéria Ernestânia Chaves Nair Honda Kawashita 《Nutrition Research》2013
We had previously shown that adipose tissue increased in rats fed a low-protein, high-carbohydrate (LPHC) diet (6% protein, 74% carbohydrate) without a simultaneous increase in the de novo fatty acids (FA) synthesis. In addition, impairment in insulin signaling in adipose tissues was observed in these rats. For this study, we hypothesized that the insulin signaling pathway is preserved in the livers from these rats, which contributes to an increase in liver lipogenesis and, consequently, an increase in the weight of the adipose tissue. We also hypothesized that glycerol from triacylglycerol is an important substrate for FA synthesis. Our results showed that administration of the LPHC diet induced an increase in the in vivo rate of total FA synthesis (150%) as well as FA synthesis from glucose (270%) in the liver. There were also increased rates of [U-14C]glycerol incorporation into glyceride-FA (15-fold), accompanied by increased glycerokinase content (30%) compared with livers of rats fed the control diet. The LPHC diet did not change the glycerol-3-phosphate generation from either glucose or glyceroneogenesis. There was an increase in the insulin sensitivity in liver from LPHC-fed rats, as evidenced by increases in IRβ (35%) levels and serine/threonine protein kinase (AKT) levels (75%), and basal (95%) and insulin-stimulated AKT phosphorylation (105%) levels. The LPHC diet also induced an increase in the liver sterol regulatory element-binding protein–1c content (50%). In summary, these data confirmed the hypothesis that lipogenesis and insulin signaling are increased in the livers of LPHC-fed rats and that glycerol is important not only for FA esterification but also for FA synthesis. 相似文献
63.
Iain A. Bruce FRCS Alexandra Jane Roper MRCS DOHNS S.L. Gayed MRCOG MFFP M. Dabrowski MB BS Pradeep Morar FRCS MD 《American journal of otolaryngology》2009,30(5):347-349
We present the case of a 38-year-old man who presented to the ENT clinic with cervical lymphadenopathy, oral ulceration, and generalized rash. He was diagnosed with syphilis after serologic testing. After years of decline, the incidence of syphilis is now increasing. It is unusual for patients to present to the otolaryngologist, but the recent marked increase in the incidence of syphilis in the UK is likely to translate into a greater incidence of pathology in the head and neck region. Knowledge of the condition, along with its head and neck manifestations, remains central to the diagnosis of this treatable infection. This article provides a summary of syphilis in the head and neck, for the latest generation of otorhinolaryngologist. 相似文献
64.
65.
Nascimento Sobrinho CL Carvalho FM Bonfim TA Cirino CA Ferreira IS 《Cadernos de saúde pública / Ministério da Saúde, Funda??o Oswaldo Cruz, Escola Nacional de Saúde Pública》2006,22(1):131-140
This cross-sectional study investigated the association between work conditions and minor psychological disorders (MPD) in a random sample of 350 doctors from Salvador City, State of Bahia, Brazil. Data were gathered using an individual, self-report questionnaire that incorporated the demand-control model (Job Content Questionnaire) to evaluate psychosocial aspects of the doctors' work and the Self-report Questionnaire (SRQ-20) to evaluate their mental health. The study found increased work overload, overtime and extended work shifts, multiple jobs, low income per hour worked, and unstable work arrangements with payment per procedure. The prevalence of MPD was 26.0% and was more strongly associated with aspects of the psychological demands of work than with the doctors' control over it. Doctors with high strain (high demand and low control) jobs showed MPD prevalence of 3.07 (95%IC: 1.38-6.85) times higher than those in low strain (low demand and high control) jobs. 相似文献
66.
67.
Fernanda S. Mazzutti Isis D. D. Custdio Mariana T. M. Lima Kamila P. de Carvalho Taísa S. S. Pereira Maria del C. B. Molina Paula P. L. Canto Carlos E. Paiva Yara C. de P. Maia 《Nutrients》2021,13(4)
The increased risk for cardiovascular diseases (CVDs) in breast cancer survivors has been widely discussed in the literature and occurs due to the cardiotoxicity of antineoplastic treatments, and also to the common risk factors between these diseases. Thus, the objective of our study was to evaluate, prospectively, the number of risk factors (NRF) for CVDs in women during endocrine therapy, and to associate the NRF with C reactive protein (CRP) and phase angle (PhA). The following risk factors for CVD were evaluated at three times: anthracycline chemotherapy, radiotherapy, comorbidities, inadequate diet, overweight, abdominal adiposity, alcoholism, smoking, physical inactivity and altered lipid profile. There was inadequacy in the most components of the Brazilian Healthy Eating Index—Revised and inadequate consumption of various types of fats and fibers. Most women in this study presented excessive abdominal fat and overweight, but these parameters have not changed over time (p < 0.005). Moreover, a high frequency of systemic arterial hypertension and physical inactivity was observed. The average NRF for CVDs was above ten, at the three evaluation times. Women with higher NRF had higher levels of CRP (p = 0.003), a predictor of cardiovascular risk, however, there was no significance with PhA (p = 0.256). Thus, intervention is needed to improve lifestyle. 相似文献
68.
Andres F. Correa Amir Toussi Milon Amin Ronald L. Hrebinko Bishoy A. Gayed Anil V. Parwani Jodi K. Maranchie 《Clinical genitourinary cancer》2018,16(4):e729-e733
Introduction
Recent reports show a correlation between renal tumor radiographic characteristics and pathologic features. We hypothesize that a more central location within the relatively hypoxic renal medulla might confer a more aggressive tumor phenotype. To test this, radiographic tumor characteristics were compared with tumor grade and histology.Materials and Methods
We retrospectively reviewed renal masses <4 cm in diameter that underwent resection between 2008 and 2013. Tumor location was recorded using standard R.E.N.A.L. Nephrometry Score. Multivariate logistic regression was performed to compare independent anatomic features with incidence of malignancy and high nuclear grade.Results
A total of 334 renal tumors had information available for analysis. Univariate analysis showed that increasing endophycity and proximity to the collecting system (<4 mm) were predictors of malignancy and high-grade features. In multivariate analysis, proximity to the collecting system <4 mm remained the as the only anatomical variable predictive of malignancy (odds ratio [OR], 3.58; 95% confidence interval [CI], 1.06-12.05; P = .04) and high nuclear grade (OR, 2.81; 95% CI, 1.44-5.51; P = .003).Conclusion
Malignancy and high tumor grade occur with much greater frequency when tumors are located deep in the kidney, in close proximity to the collecting system and renal sinus. Ninety-six percent of small renal masses in this region were cancers and nearly half were Fuhrman Grade 3 or 4, suggesting that these small centrally located tumors should be targeted for early intervention. 相似文献69.
Isis Ludwig‐Portugall Emma E. Hamilton‐Williams Janine Gotot Christian Kurts 《European journal of immunology》2009,39(1):225-233
To study B‐cell tolerance against non‐lymphoid tissue autoantigens, we generated transgenic rat insulin promoter (RIP)‐OVA/hen egg lysozyme (HEL) mice expressing the model antigens, OVA and HEL, in pancreatic islets. Their vaccination with OVA or HEL induced far less auto‐Ab titers compared with non‐transgenic controls. Depletion of CD25+ cells during immunization completely restored auto‐Ab production, but did not affect antibodies against a foreign control antigen. Depletion at later time‐points was not effective. OVA‐specific CD25+ FoxP3+ Treg were more frequent in the autoantigen‐draining pancreatic LN than in other secondary lymphatics of RIP‐OVA/HEL mice. Consistently, B cells were suppressed in that LN and also in the spleen, which is known to concentrate circulating antigen, such as the antigens used for vaccination. Suppression involved preventing expansion of autoreactive B cells in response to autoantigen, reducing antibody production per B‐cell and isotype changes. These findings demonstrate that CD25+ Treg suppress auto‐Ab production against non‐lymphoid tissue antigens in an antigen‐specific manner. 相似文献
70.
HIV discrimination and the health of women living with HIV 总被引:1,自引:0,他引:1
Wingood GM Diclemente RJ Mikhail I McCree DH Davies SL Hardin JW Harris Peterson S Hook EW Saag M 《Women & health》2007,46(2-3):99-112
Women living with HIV are especially vulnerable to discrimination because of the stigma associated with the disease, as well as their race, gender and class status. To investigate the association between self-reported HIV discrimination and health outcomes among African- American and white women living with HIV, 366 women living with HIV were recruited from HIV/AIDS clinics in Georgia and Alabama. In this cross-sectional study, participants completed an interview that assessed self-reported HIV discrimination and depressive symptomatology, suicidal ideation, self-esteem, stress, quality of life, sexual health and HIV/AIDS related health care seeking. Nearly a sixth of the sample reported experiencing HIV discrimination. Women reporting HIV discrimination had higher mean scores for stress, suicidal ideation, depressive symptoms, number of unprotected sexual episodes; they had lower mean scores for self-esteem, and quality of life, and were more likely to have not sought medical care for HIV/AIDS. In race-specific analyses, none of the relationships between HIV discrimination and health outcomes were significant for white women. African-American women who reported HIV discrimination had higher mean scores for stress, suicidal ideation, depressive symptoms, number of unprotected sexual episodes; they had lower mean scores for self-esteem, and quality of life, and were more likely not to have sought medical care for HIV/AIDS. The findings indicated that HIV discrimination adversely affects women's mental, sexual and physical health. However, separate race-specific analyses indicated that compared to white women, African-American women were markedly more likely to experience the adverse affects of HIV discrimination. Eradication of HIV discrimination remains an important public health priority. 相似文献