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排序方式: 共有1932条查询结果,搜索用时 93 毫秒
71.
Juan C. Morilla-Herrera RN MSc PhD José M. Morales-Asencio RN BSc PhD Alberto J. Gómez-González RN MSc Antonio Díez-De Los Ríos RN Inmaculada Lupiáñez-Pérez RN MSc PhD Carlos Acosta-Andrade BSB MSc PhD Marta Aranda-Gallardo RN MSc PhD Ana B. Moya-Suárez RN MSc PhD Shakira Kaknani-Uttumchandani RN MSc PhD Silvia García-Mayor RN MSc PhD 《Journal of advanced nursing》2020,76(8):2191-2197
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Kirstin R. W. Matthews Ana S. Iltis Nuria Gallego Marquez Daniel S. Wagner Jason Scott Robert Inmaculada de Melo‐Martín Marieke Bigg Sarah Franklin Soren Holm Ingrid Metzler Matteo A. Mol Jochen Taupitz Giuseppe Testa Jeremy Sugarman 《The Hastings Center report》2021,51(1):47-51
It now seems technically feasible to culture human embryos beyond the “fourteen‐day limit,” which has the potential to increase scientific understanding of human development and perhaps improve infertility treatments. The fourteen‐day limit was adopted as a compromise but subsequently has been considered an ethical line. Does it remain relevant in light of technological advances permitting embryo maturation beyond it? Should it be changed and, if so, how and why? What justifications would be necessary to expand the limit, particularly given that doing so would violate some people's moral commitments regarding human embryos? Robust stakeholder engagement preceded adoption of the fourteen‐day limit and should arguably be part of efforts to reassess it. Such engagement could also consider the need for enhanced oversight of human embryo research. In the meantime, developing and implementing reliable oversight systems should help foster high‐quality research and public confidence in it. 相似文献
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Gemma Rojo-Martínez Sergio Valdés Natalia Colomo M. Isabel Lucena Sonia Gaztambide Ramón Gomis Roser Casamitjana Rafael Carmena Miguel Catalá María T. Martínez-Larrad Manuel Serrano-Ríos Luis Castaño Joan Vendrell Juan Girbés Josep Franch José A. Vázquez Inmaculada Mora-Peces Inés Urrutia Gemma Pascual-Manich Emilio Ortega Edelmiro Menéndez Elias Delgado Elena Bordiú Conxa Castell Alfonso López-Alba Alberto Goday Alfonso Calle Anna Bosch-Comas Federico Soriguer 《Revista espa?ola de cardiología》2013
76.
Teresa Rodríguez-Martín Inmaculada Cuchillo-Ibáñez Wendy Noble Fanon NyenyaBrian H. Anderton Diane P. Hanger 《Neurobiology of aging》2013
Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease. To investigate the effects of specific phosphorylated tau residues on its function, wild type or phosphomutant tau was expressed in cells. Elevated tau phosphorylation decreased its microtubule binding and bundling, and increased the number of motile tau particles, without affecting axonal transport kinetics. In contrast, reducing tau phosphorylation enhanced the amount of tau bound to microtubules and inhibited axonal transport of tau. To determine whether differential tau clearance is responsible for the increase in phosphomimic tau, we inhibited autophagy in neurons which resulted in a 3-fold accumulation of phosphomimic tau compared with wild type tau, and endogenous tau was unaffected. In autophagy-deficient mouse embryonic fibroblasts, but not in neurons, proteasomal degradation of phosphomutant tau was also reduced compared with wild type tau. Therefore, autophagic and proteasomal pathways are involved in tau degradation, with autophagy appearing to be the primary route for clearing phosphorylated tau in neurons. Defective autophagy might contribute to the accumulaton of tau in neurodegenerative diseases. 相似文献
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Acupuncture in patients with acute low back pain: A multicentre randomised controlled clinical trial
J Vas JM Aranda M Modesto N Benítez-Parejo A Herrera DM Martínez-Barquín I Aguilar M Sánchez-Araujo F Rivas-Ruiz 《Pain》2012,153(9):1883-1889
Reviews of the efficacy of acupuncture as a treatment for acute low back pain have concluded that there is insufficient evidence for its efficacy and that more research is needed to evaluate it. A multicentre randomized controlled trial was conducted at 4 primary-care centres in Spain to evaluate the effects of acupuncture in patients with acute nonspecific low back pain in the context of primary care. A total of 275 patients with nonspecific acute low back pain (diagnosed by their general practitioner) were recruited and assigned randomly to 4 different groups: conventional treatment either alone or complemented by 5 sessions over a 2-week period of true acupuncture, sham acupuncture, or placebo acupuncture per patient. Patients were treated from February 2006 to January 2008. The primary outcome was the reduction in Roland Morris Disability Questionnaire scores of 35% or more after 2weeks' treatment. The patients in the 3 types of acupuncture groups were blinded to the treatments, but those who received conventional treatment alone were not. In the analysis adjusted for the total sample (true acupuncture relative risk 5.04, 95% confidence interval 2.24-11.32; sham acupuncture relative risk 5.02, 95% confidence interval 2.26-11.16; placebo acupuncture relative risk 2.57 95% confidence interval 1.21-5.46), as well as for the subsample of occupationally active patients, all 3 modalities of acupuncture were better than conventional treatment alone, but there was no difference among the 3 acupuncture modalities, which implies that true acupuncture is not better than sham or placebo acupuncture. 相似文献
80.
Francisco Salazar Luis San FrutosVirginia Engels Beatriz BuenoTirso Pérez-Medina Inmaculada OrensanzJosé Bajo 《Progresos de Obstetricia y Ginecología》2008