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91.
Werner Irnich Burkhard Irnich Christine Bartsch Wilhelm Alfred Stertmann Hubert Gufler Guenter Weiler 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2005,7(4):353-365
AIMS: Manufacturers of pacemakers (PM) and of magnetic resonance imaging (MRI) devices state that MRI scanning of PM wearers is contraindicated. This paper tries to summarise which effects can interfere with PM, what can be hazardous, and how treatment of PM in MRI can be modified to guarantee compatibility. MATERIAL AND METHODS: All PM tested were from deceased patients. Reed contact thresholds and reactions were investigated in low magnetostatic fields and compared with those in strong magnetostatic fields. Influence of gradient fields on PM and heating due to radiofrequency (RF) pulses were estimated. Thirty Legal Medicine Departments were questioned whether deaths of PM patients during MRI are known. RESULTS: Reed contacts are influenced above 0.7 mT. In MRI fields only 28% of the PM in magnet mode remained so in all orientations. Of synchronous PM, 76% remained synchronous in all orientations. Gradient fields can influence sensing but cannot stimulate. Power density and temperature rise produced by RF fall rapidly with distance. Our question revealed six deaths. All suffered from sick-sinus-syndrome and all were not PM dependent. In three cases ventricular fibrillation was proven as the cause of death. DISCUSSION: Asynchronous pacing due to magnetostatic and gradient fields may be problematic in patients with spontaneous rhythm. To avoid them, PM triggered MRI scan restricted to refractory period is proposed. Neither inhibition of PM nor heating of the electrode poses real risks. So far, we have examined eight patients 12 times in MRI triggered mode without problems. 相似文献
92.
93.
A MicroRNA-Based Test Improves Endoscopic Ultrasound–Guided Cytologic Diagnosis of Pancreatic Cancer
Randall E. Brand Alex T. Adai Barbara A. Centeno Linda S. Lee George Rateb Shivakumar Vignesh Charles Menard Anna Wiechowska–Kozłowska Hubert Bołdys Marek Hartleb Michael K. Sanders Johanna B. Munding Andrea Tannapfel Stephan A. Hahn Ludomir Stefańczyk Gregory J. Tsongalis David C. Whitcomb Darwin L. Conwell Jean A. Morisset Timothy B. Gardner Stuart R. Gordon Arief A. Suriawinata Maura B. Lloyd Dennis Wylie Emmanuel Labourier Bernard F. Andruss Anna E. Szafranska–Schwarzbach 《Clinical gastroenterology and hepatology》2014,12(10):1717-1723
94.
Leonard Schuele Hayley Cassidy Erley Lizarazo Katrin Strutzberg-Minder Sabine Schuetze Sandra Loebert Claudia Lambrecht Juergen Harlizius Alex W. Friedrich Silke Peter Hubert G. M. Niesters John W. A. Rossen Natacha Couto 《Viruses》2020,12(12)
Shotgun metagenomic sequencing (SMg) enables the simultaneous detection and characterization of viruses in human, animal and environmental samples. However, lack of sensitivity still poses a challenge and may lead to poor detection and data acquisition for detailed analysis. To improve sensitivity, we assessed a broad scope targeted sequence capture (TSC) panel (ViroCap) in both human and animal samples. Moreover, we adjusted TSC for the Oxford Nanopore MinION and compared the performance to an SMg approach. TSC on the Illumina NextSeq served as the gold standard. Overall, TSC increased the viral read count significantly in challenging human samples, with the highest genome coverage achieved using the TSC on the MinION. TSC also improved the genome coverage and sequencing depth in clinically relevant viruses in the animal samples, such as influenza A virus. However, SMg was shown to be adequate for characterizing a highly diverse animal virome. TSC on the MinION was comparable to the NextSeq and can provide a valuable alternative, offering longer reads, portability and lower initial cost. Developing new viral enrichment approaches to detect and characterize significant human and animal viruses is essential for the One Health Initiative. 相似文献
95.
Hubert Barennes Günther Slesak Yves Buisson Peter Odermatt 《The American journal of tropical medicine and hygiene》2014,90(2):384-385
The purpose of this report is to compare the prevalence of Opisthorchis viverrini/minute intestinal fluke (Ov/MIF) in Lao People''s Democratic Republic according to different regions and evaluate the effect of ingestion of raw freshwater fish on the infection. Demographic data, behavioral data, and symptoms were obtained, and the Kato–Katz method was used for the diagnosis of Ov/MIF. In total, 3,046 individuals were enrolled. The risk factors associated with acquisition of Ov/MIF were raw fish consumption and province. Khong Island showed the highest prevalence (odds ratio = 80.1, 95% confidence interval = 47.9–133.9, P < 0.001) compared with other districts, and raw fish consumption was related to Ov/MIF infection. Administration of praziquantel to entire populations, education (avoiding consumption of raw food dishes and improved hygiene), and access to clean water and sanitation should be considered. 相似文献
96.
97.
Felix Aberer MD Peter N. Pferschy MSc Norbert J. Tripolt PhD Caren Sourij MD Anna M Obermayer MD Florian Prüller MD Eva Novak MD Philipp Reitbauer Harald Kojzar BSc Barbara Prietl PhD Selina Kofler BSc Martina Brunner MSc Eva Svehlikova MD Tatjana Stojakovic MD Hubert Scharnagl MD Abderrahim Oulhaj PhD Faisal Aziz Msc Regina Riedl PhD Harald Sourij MD 《Diabetes, obesity & metabolism》2020,22(2):212-221
98.
Maria Torner Adjmal Mangal Hubert Scharnagl Christian Jansen Michael Praktiknjo Alexander Queck Wenyi Gu Robert Schierwagen Jennifer Lehmann Frank E. Uschner Christiana Graf Christian P. Strassburg Javier Fernandez Tatjana Stojakovic Rainer Woitas Jonel Trebicka 《Liver international》2020,40(1):186-193
99.
Scherptong RW Henkens IR Kapel GF Swenne CA van Kralingen KW Huisman MV Schuerwegh AJ Bax JJ van der Wall EE Schalij MJ Vliegen HW 《Journal of electrocardiology》2012,45(3):312-318
PurposeThe aim of this study was to investigate the use of the electrocardiogram-derived ventricular gradient, projected on the x-axis (VGx), for detection of pulmonary hypertension (PH) and for prediction of all-cause mortality in PH patients.MethodsIn patients referred for PH screening (n = 216), the VGx was calculated semiautomatically from the electrocardiogram and was defined as abnormal when less than 24 mV·ms. The VGx of PH patients was compared with the VGx of patients without PH. The association between a reduced VGx and mortality was investigated in PH patients.ResultsPatients with PH (n = 117) had a significantly reduced VGx: 14 ± 27 vs 45 ± 23 mV·ms, P < .001. Furthermore, a severely reduced VGx (<0 mV·ms) was associated with increased mortality in PH patients: hazard ratio, 1.025 (95% confidence interval, 1.006-1.045; P = .012) per mV·ms VGx decrease.ConclusionReduced VGx is associated with the presence of PH and, more importantly, within PH patients, a severely reduced VGx predicts mortality. 相似文献
100.
Robertson MD Wright JW Loizon E Debard C Vidal H Shojaee-Moradie F Russell-Jones D Umpleby AM 《The Journal of clinical endocrinology and metabolism》2012,97(9):3326-3332
Context: Dietary fibers have been associated with a reduced incidence of type 2 diabetes mellitus in epidemiological studies; however, the precise mechanisms are unknown. Objective: The objective of the study was to evaluate the efficacy and site of action of an insoluble dietary fiber derived from maize (HAM-RS2) in improving insulin resistance in subjects at increased risk of type 2 diabetes mellitus. Design: This study was a randomized, controlled crossover, dietary intervention study. Setting: The study was conducted at the Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, United Kingdom. Participants: Fifteen men and women with insulin resistance participated in the study. Intervention: The intervention included 40 g/d HAM-RS2 compared with a matched placebo for 8 wk. Main Outcome Measures: After each supplement, participants underwent a two-step hyperinsulinemic-euglycemic clamp study with the addition of glucose tracers; a meal tolerance test; arteriovenous sampling across forearm muscle tissue; and a sc adipose tissue biopsy for assessment of gene expression. Results: There was enhanced uptake of glucose into the forearm muscle measured by arteriovenous sampling (65 ± 15% increase after resistant starch; P < 0.001). Adipose tissue function was also affected, with enhanced fatty acid suppression after HAM-RS2 treatment and an increase in gene expression for hormone sensitive lipase (P = 0.005), perilipin (P = 0.011), lipoprotein lipase (P = 0.014), and adipose triglyceride lipase (P = 0.03) in biopsy samples. There was no effect on the insulin sensitivity of hepatic glucose production or plasma lipids after HAM-RS2. Conclusion: HAM-RS2 improved peripheral but not hepatic insulin resistance and requires further study as an intervention in patients with or at risk for type 2 diabetes. 相似文献