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81.
82.
Laryngeal tuberculosis: a review of 26 cases. 总被引:2,自引:0,他引:2
Chen-Chi Wang Chang-Chun Lin Ching-Ping Wang Shih-An Liu Rong-San Jiang 《Otolaryngology--head and neck surgery》2007,137(4):582-588
OBJECTIVES: To review the clinical characteristics of laryngeal tuberculosis. STUDY DESIGN: Retrospective case series. SUBJECTS AND METHODS: Medical records of 26 histopathology-confirmed cases in a tertiary medical center from 1992 to 2006. RESULTS: The female patients were significantly younger than male patients. Hoarseness is the most common symptom (84.6%) because true vocal fold is most commonly involved (80.8%). Infection usually involves unilateral (66.7%) and right-side larynx but multiple subsites of the larynx (57.7%). The appearance of the affected larynx may have mixed features and change before diagnosis. Laryngeal tuberculosis is usually misdiagnosed as laryngeal cancer, especially in patients with malignant signs such as enlarged cervical lymph nodes and vocal fold immobility. Chest film is better than sputum examinations for screening. CONCLUSION: We should be especially alert about TB infection when facing young female patients with unusual laryngeal lesions. Extensive laser excision before diagnosis should be avoided because after antituberculous treatment, prognosis is usually good and vocal fold immobility could be reversible. 相似文献
83.
Li Li Alice C Jiang Pin Dong Yi Wan Zi Wei Yu 《Otolaryngology--head and neck surgery》2007,137(4):659-664
OBJECTIVE: To investigate the characteristics of Hep-2 cell with multidrug resistance (MDR) induced by Taxol. STUDY DESIGN: Hep-2 cells were exposed in stepwise escalating concentration of Taxol to develop the resistant cell line-Hep-2T. Cell cycle distribution, apoptosis, and rhodamine accumulation were studied through flow cytometry. The MDR1 and MRP1 genes were detected through real-time quantitative RT-PCR, and the corresponding proteins were detected through Western blotting. RESULTS: The drug resistance of Hep-2T cells to Taxol, doxorubicin, gemcitabine, 5-FU, and cisplatin all increased. The percentage of G0/G1 phase and the antiapoptosis ability increased significantly compared with Hep-2 cells. Both MDR1 and MRP1 also increased at gene and protein level, though MDR1 was more prominent. CONCLUSION: More emphasis should be laid on MDR1/Pgp, the non-Pgp substrate chemotherapeutic agents, and the changes of cell cycle distribution to prevent MDR induced by Taxol. SIGNIFICANCE: These findings may provide theoretical support for the reverse of MDR. 相似文献
84.
85.
50例冠心病某些生化基础观测的临床诊断意义 总被引:1,自引:0,他引:1
对50例冠心病患者进行某些生化基础观测,发现冠心病肾阴虚与糖耐量减低有关,肾阳虚患者尿17-羟低於正常;而冠心病标证有其生化基础,与甘油三酯增高有密切相关。 相似文献
86.
87.
本研究主要对El Tor型霍乱弧菌(Vibrio cholerae biotvpe eltor,EVC)L型的某些生物学特性如生化反应、抗生素敏感性及超微结构等进行了探讨.研究发现EVC不稳定L型的生化性状与EVC流行株的非常相似,而稳定L型则变化很大.抗生素敏感性试验显示EVC稳定L型对某些作用于细胞壁的抗生素的敏感性减弱,而对大多数作用于蛋白质合成的抗生素的敏感性增强.与流行株相比,EVC稳定L型和不稳定L型的超微结构的改变很明显.此外,本文还讨论了产生这些改变的可能机制. 相似文献
88.
89.
原发性干燥综合征与人类组织相容性抗原—DRβ基因 总被引:1,自引:0,他引:1
原发性干燥综合征(PSS)的病因未明,其中可能涉及遗传因素。用序列特异性引物聚合酶链反应(PCR-SSP)法对70例PSS患者和136名正常人进行人类组织相容性抗原(HLA)-DRβ基因分型。发现PSS患者群体的HLA-DR3、DR52及DR2的基因频率明显高于正常对照组,而HLA-DR5及DR9的基因频率则相反,提示PSS的发病与DR3、DR52及DR2呈正相关;而和DR9、DR5呈负相关。2个PSS患者家族的姐妹与患者具有相同的遗传因素,且和PSS患者群体测定的正相关基因相一致。PSS患者的主要自身抗体(抗SSA抗体及抗SSB抗体)与HLA-DR52之间有明显的相关性,因而表明PSS的发病和遗传因素有关。 相似文献
90.
Population toxicokinetics of tetrachloroethylene 总被引:1,自引:0,他引:1
F. Y. Bois A. Gelman J. Jiang D. R. Maszle L. Zeise G. Alexeef 《Archives of toxicology》1996,70(6):347-355
In assessing the distribution and metabolism of toxic compounds in the body, measurements are not always feasible for ethical
or technical reasons. Computer modeling offers a reasonable alternative, but the variability and complexity of biological
systems pose unique challenges in model building and adjustment. Recent tools from population pharmacokinetics, Bayesian statistical
inference, and physiological modeling can be brought together to solve these problems. As an example, we modeled the distribution
and metabolism of tetrachloroethylene (PERC) in humans. We derive statistical distributions for the parameters of a physiological
model of PERC, on the basis of data from Monster et al. (1979). The model adequately fits both prior physiological information
and experimental data. An estimate of the relationship between PERC exposure and fraction metabolized is obtained. Our median
population estimate for the fraction of inhaled tetrachloroethylene that is metabolized, at exposure levels exceeding current
occupational standards, is 1.5% [95% confidence interval (0.52%, 4.1%)]. At levels approaching ambient inhalation exposure
(0.001 ppm), the median estimate of the fraction metabolized is much higher, at 36% [95% confidence interval (15%, 58%)].
This disproportionality should be taken into account when deriving safe exposure limits for tetrachloroethylene and deserves
to be verified by further experiments.
Received: 20 April 1995/Accepted: 24 August 1995 相似文献